DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14695 and DNAJC10

DIOPT Version :9

Sequence 1:	NP_650032.1	Gene:	CG14695 / 41314	FlyBaseID:	FBgn0037850	Length:	289	Species:	Drosophila melanogaster
Sequence 2:	NP_061854.1	Gene:	DNAJC10 / 54431	HGNCID:	24637	Length:	793	Species:	Homo sapiens

Alignment Length:	201	Identity:	40/201 - (19%)
Similarity:	63/201 - (31%)	Gaps:	72/201 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 NNSIPWIL-----WLPP----LTEVDRKSP--GGRFTFDGPKVVAFHFVKNRHGDTLDKWISLLD 64
            |:..||::     |.||    |.|:.|.|.  .|:..|..........:.|.:.
Human   466 NDKEPWLVDFFAPWCPPCRALLPELRRASNLLYGQLKFGTLDCTVHEGLCNMYN----------- 519

  Fly    65 ELAQEYAGRILFGLRDISNIGEFNPNLNPDDFGSYRKGLPPRIYGKDCEGRVYDMHKLVNAKYLR 129
              .|.|...::|   :.|||.|                              |:.|.  :|:.:.
Human   520 --IQAYPTTVVF---NQSNIHE------------------------------YEGHH--SAEQIL 547

  Fly   130 EFCDQLLADQLFRAVVLGATASLDSKPMNYFELREESSSDMLVMLYDPACY----YWPIQKRMLR 190
            ||.:.|:..         :..||.....|....:.:.:...:|..|.|.|:    ..|..|||.|
Human   548 EFIEDLMNP---------SVVSLTPTTFNELVTQRKHNEVWMVDFYSPWCHPCQVLMPEWKRMAR 603

  Fly   191 KLIRLL 196
            .|..|:
Human   604 TLTGLI 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14695	NP_650032.1	Thioredoxin_6	<20..134	CDD:290560	21/119 (18%)
DNAJC10	NP_061854.1	DnaJ	34..>132	CDD:223560
		PDI_a_ERdj5_N	129..229	CDD:239301
		Trxb 1	235..350
		Trxb 2	348..463
		PDI_a_ERdj5_C	453..550	CDD:239302	24/131 (18%)
		PDI_a_ERdj5_C	556..663	CDD:239302	14/63 (22%)
		PDI_a_ERdj5_C	670..775	CDD:239302
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	790..793
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900