DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14695 and Pdia5

DIOPT Version :9

Sequence 1:	NP_650032.1	Gene:	CG14695 / 41314	FlyBaseID:	FBgn0037850	Length:	289	Species:	Drosophila melanogaster
Sequence 2:	NP_001014147.1	Gene:	Pdia5 / 360722	RGDID:	1359236	Length:	517	Species:	Rattus norvegicus

Alignment Length:	150	Identity:	32/150 - (21%)
Similarity:	57/150 - (38%)	Gaps:	32/150 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 KVVAFHFVKNRHGDTLDKWISLLDELA--QEYAGRILF----GLRDISNIG---EFNPNLNPDDF 96
            |:..||:.........|:.::|...:|  ::..|..|:    |.:|:.:|.   :|...|..::
  Rat   105 KIELFHYQDGAFHMQYDRAVTLKSIVAFLKDPKGPPLWEEDPGAKDVVHIDSEKDFRRLLKKEE- 168

  Fly    97 GSYRKGLPPRIYGKDCEGRVYDMHKLVNAKYLREFCDQLLADQLFRAVVLGATASLDSKPMNYFE 161
                |.|....|...|     .|.|.:...:      |..|.|:....||   |.::..|..:..
  Rat   169 ----KPLLMMFYAPWC-----SMCKRIMPHF------QKAATQVRGHTVL---AGMNVYPPEFEN 215

  Fly   162 LREESSSDMLVMLYDPACYY 181
            ::||.:    |..|...||:
  Rat   216 IKEEYN----VRGYPTICYF 231

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14695	NP_650032.1	Thioredoxin_6	<20..134	CDD:290560	19/101 (19%)
Pdia5	NP_001014147.1	PDI_b_PDIR_N	26..137	CDD:239365	6/31 (19%)
		PDI_a_PDIR	150..254	CDD:239295	23/104 (22%)
		ER_PDI_fam	166..501	CDD:273457	19/88 (22%)
		PDI_a_PDIR	275..377	CDD:239295
		PDI_a_PDIR	396..499	CDD:239295
		Prevents secretion from ER. /evidence=ECO:0000255	514..517
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900