DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14695 and P4hb

DIOPT Version :9

Sequence 1:	NP_650032.1	Gene:	CG14695 / 41314	FlyBaseID:	FBgn0037850	Length:	289	Species:	Drosophila melanogaster
Sequence 2:	NP_037130.2	Gene:	P4hb / 25506	RGDID:	3244	Length:	509	Species:	Rattus norvegicus

Alignment Length:	367	Identity:	65/367 - (17%)
Similarity:	124/367 - (33%)	Gaps:	116/367 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KTYTIDNNSIPWILWL-----PPLTEVDRKSPGGRFTFDGPKVVAFHFVKNRHGDTLDKWISLLD 64
            |.||....:...:.||     |..|.:. .:.......|..:|....|.|:...|:..:::
  Rat   116 KEYTAGREADDIVNWLKKRTGPAATTLS-DTAAAESLVDSSEVTVIGFFKDAGSDSAKQFL---- 175

  Fly    65 ELAQEYAGRILFGLRDISNI---------------------GEFNPNLNPD---DFGSYRKGLP- 104
             ||.|....|.||:...|::                     ..|...:..:   ||..:.: ||
  Rat   176 -LAAEAVDDIPFGITSNSDVFSKYQLDKDGVVLFKKFDEGRNNFEGEITKEKLLDFIKHNQ-LPL 238

  Fly   105 ---------PRIYGKDCEGRV----------YDMHKLVNAKYLRE-FCDQLLADQLFRAVVLGAT 149
                     |:|:|.:.:..:          || .||.|.|...| |..::|      .:.:.:.
  Rat   239 VIEFTEQTAPKIFGGEIKTHILLFLPKSVSDYD-GKLSNFKKAAEGFKGKIL------FIFIDSD 296

  Fly   150 ASLDSKPMNYFEL-REESSSDMLVML------YDPA------------CYYW---PIQKRML--- 189
            .:.:.:.:.:|.| :||..:..|:.|      |.|.            |:::   .|:..::
  Rat   297 HTDNQRILEFFGLKKEECPAVRLITLEEEMTKYKPESDELTAEKITQFCHHFLEGKIKPHLMSQE 361

  Fly   190 ------RKLIRLLASEDLPIVIVDKANNYLGVGFTRWLQMVNCHGSTIFTSPRRDGWDIKLS--- 245
                  ::.:::|..::...|..|:..|.....:..|     | |.....:|.   || ||.
  Rat   362 LPEDWDKQPVKVLVGKNFEEVAFDEKKNVFVEFYAPW-----C-GHCKQLAPI---WD-KLGETY 416

  Fly   246 --------VRMESTRGYLRYIARNRQPELIDFDADGEPRALE 279
                    .:|:||...:..:..:..|.|..|.|..:...::
  Rat   417 KDHENIVIAKMDSTANEVEAVKVHSFPTLKFFPASADRTVID 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14695	NP_650032.1	Thioredoxin_6	<20..134	CDD:290560	31/163 (19%)
P4hb	NP_037130.2	ER_PDI_fam	26..476	CDD:273457	65/367 (18%)
P4hb	NP_037130.2	Prevents secretion from ER	506..509
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000292
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000