DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14695 and PDILT

DIOPT Version :9

Sequence 1:	NP_650032.1	Gene:	CG14695 / 41314	FlyBaseID:	FBgn0037850	Length:	289	Species:	Drosophila melanogaster
Sequence 2:	NP_777584.1	Gene:	PDILT / 204474	HGNCID:	27338	Length:	584	Species:	Homo sapiens

Alignment Length:	270	Identity:	51/270 - (18%)
Similarity:	103/270 - (38%)	Gaps:	69/270 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ILWLPPLTEVDRKSPGGRFTFDGPKVVAFHFVKNRHGDTLDKWISLLDELAQEYAG------RIL 75
            ::||  ..::.:|:    |.|:..:.|| .||.:|....:..:..|.:|:|:.:..      .:.
Human   145 VVWL--RRQISQKA----FLFNSSEQVA-EFVISRPLVIVGFFQDLEEEVAELFYDVIKDFPELT 202

  Fly    76 FGLRDISN-IGEFNPNLNPDDFGSYRKGLPPRIYGKDCEGRVYDMHKLVNAKYLREFCDQLLADQ 139
            ||:..|.| ||.|:..|  |....::|            |::.:..||:|....::..::::...
Human   203 FGVITIGNVIGRFHVTL--DSVLVFKK------------GKIVNRQKLINDSTNKQELNRVIKQH 253

  Fly   140 LFRAVVLGATASLD-------SKPMNYFELREESSSDMLVMLYDPACYYWPIQKRMLRKLIRLLA 197
            |...|:...|.:.|       ...|..|..:...|..:::..|..|      .|....|::.:|.
Human   254 LTDFVIEYNTENKDLISELHIMSHMLLFVSKSSESYGIIIQHYKLA------SKEFQNKILFILV 312

  Fly   198 SEDLP----------IVIVDKANNYLGVGFTRWLQMVNCHGSTIFTSPRRDGWDIKLSVRMESTR 252
            ..|.|          :..||..:          :|::|......:..|..|       :..||.:
Human   313 DADEPRNGRVFKYFRVTEVDIPS----------VQILNLSSDARYKMPSDD-------ITYESLK 360

  Fly   253 GYLR-YIARN 261
            .:.| ::::|
Human   361 KFGRSFLSKN 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14695	NP_650032.1	Thioredoxin_6	<20..134	CDD:290560	26/120 (22%)
PDILT	NP_777584.1	YbbN	46..501	CDD:331940	51/270 (19%)
PDILT	NP_777584.1	Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	581..584
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810