DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14695 and Pdia3

DIOPT Version :9

Sequence 1:	NP_650032.1	Gene:	CG14695 / 41314	FlyBaseID:	FBgn0037850	Length:	289	Species:	Drosophila melanogaster
Sequence 2:	NP_031978.2	Gene:	Pdia3 / 14827	MGIID:	95834	Length:	505	Species:	Mus musculus

Alignment Length:	298	Identity:	62/298 - (20%)
Similarity:	113/298 - (37%)	Gaps:	74/298 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 PPLTEVDRKSPGGRFTFDGPKVVAFH---FVKNRHGDTLDKWISLLDELAQEY--AG-RILFGLR 79
            |.:||.::....|:     ..:.|::   :.||..|.  :.|.:.:..:|:::  || ::.|.
Mouse   245 PHMTEDNKDLIQGK-----DLLTAYYDVDYEKNAKGS--NYWRNRVMMVAKKFLDAGHKLNFA-- 300

  Fly    80 DISNIGEFNPNLNPDDFG-SYRKGLPPRIYGKDCEGRVYDMHKLV--NAKYLREFCDQLLADQLF 141
             :::...|:..|:  ||| ....|..|.:..:..:|..:.|.:..  :.|.|.:|..:.....|.
Mouse   301 -VASRKTFSHELS--DFGLESTTGEVPVVAIRTAKGEKFVMQEEFSRDGKALEQFLQEYFDGNLK 362

  Fly   142 RAVVLGATASLDSKPM--------------NYFELREESSSDMLVMLYDPACYYW----PIQKRM 188
            |        .|.|:|:              |:.::..|...|:|:..|.|.|.:.    |..|.:
Mouse   363 R--------YLKSEPIPESNEGPVKVVVAENFDDIVNEEDKDVLIEFYAPWCGHCKNLEPKYKEL 419

  Fly   189 LRKLIRLLASEDLPIVIV-------DKANNYLGVGFTRWLQMVNCHGSTIFTSPRRDGWDIKLSV 246
            ..||     |:|..|||.       |..:.|...||           .||:.||.......|...
Mouse   420 GEKL-----SKDPNIVIAKMDATANDVPSPYEVKGF-----------PTIYFSPANKKLTPKKYE 468

  Fly   247 RMESTRGYLRYIARN-RQPELIDFDADGEPRALEQAVE 283
            .......::.|:.|. ..|.:|.   :.:|:..::|.|
Mouse   469 GGRELNDFISYLQREATNPPIIQ---EEKPKKKKKAQE 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14695	NP_650032.1	Thioredoxin_6	<20..134	CDD:290560	25/121 (21%)
Pdia3	NP_031978.2	ER_PDI_fam	26..487	CDD:273457	57/277 (21%)
		Thioredoxin	27..131	CDD:278513
		PDI_b_ERp57	135..240	CDD:239367
		PDI_b'_ERp72_ERp57	244..357	CDD:239371	25/123 (20%)
		PDI_a_PDI_a'_C	377..480	CDD:239293	25/118 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	484..505		5/23 (22%)
		Prevents secretion from ER. /evidence=ECO:0000250	502..505		1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000292
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000