DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14695 and Pdia4

DIOPT Version :9

Sequence 1:	NP_650032.1	Gene:	CG14695 / 41314	FlyBaseID:	FBgn0037850	Length:	289	Species:	Drosophila melanogaster
Sequence 2:	NP_001355685.1	Gene:	Pdia4 / 12304	MGIID:	104864	Length:	699	Species:	Mus musculus

Alignment Length:	244	Identity:	46/244 - (18%)
Similarity:	81/244 - (33%)	Gaps:	100/244 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 SLLDELAQEYAGRILFGLRDISNIGEFNPNLNPDDFGS---------YRKG-LPPRIYG----KD 111
            ::|||..:::|                   :.|::|.|         ::|| |.|.|..    |:
Mouse   531 AILDESGKKFA-------------------MEPEEFDSDTLREFVTAFKKGKLKPVIKSQPVPKN 576

  Fly   112 CEGRVYDMHKLVNAKYLREFCDQLLADQLFRAVVLGATASLDSKPMNYFELREESSSDMLVMLYD 176
            .:|.|                 :::..:.|.|:|:                  :...|:|:..|.
Mouse   577 NKGPV-----------------KVVVGKTFDAIVM------------------DPKKDVLIEFYA 606

  Fly   177 PACYYW----PIQKRMLRKLIRLLASEDLPIVIVDKANN------YLGVGFTRWLQMVNCHGSTI 231
            |.|.:.    ||...:.:|   ....:||.|..:|...|      |...||           .||
Mouse   607 PWCGHCKQLEPIYTSLGKK---YKGQKDLVIAKMDATANDITNDQYKVEGF-----------PTI 657

  Fly   232 FTSPRRDGWDIKLSVRMESTRGYLRYIARNRQPELIDFDADGEPRALEQ 280
            :.:|   ..|.|..::.|.....|.::::     .||..|....|..|:
Mouse   658 YFAP---SGDKKNPIKFEGGNRDLEHLSK-----FIDEHATKRSRTKEE 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14695	NP_650032.1	Thioredoxin_6	<20..134	CDD:290560	15/86 (17%)
Pdia4	NP_001355685.1	pdi_dom	63..164	CDD:273454
Pdia4	NP_001355685.1	ER_PDI_fam	173..691	CDD:273457	44/235 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000292
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000