DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14695 and ERP27

DIOPT Version :9

Sequence 1:	NP_650032.1	Gene:	CG14695 / 41314	FlyBaseID:	FBgn0037850	Length:	289	Species:	Drosophila melanogaster
Sequence 2:	NP_689534.1	Gene:	ERP27 / 121506	HGNCID:	26495	Length:	273	Species:	Homo sapiens

Alignment Length:	161	Identity:	29/161 - (18%)
Similarity:	54/161 - (33%)	Gaps:	64/161 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IDNNSIPWILWLPPLTEVDRKSPGGRFTFDGPKVVAFH--FVKNRHGDTLDKWISLLDELAQEYA 71
            |:.||:..:....|:|.:      |.|.    .|:..|  .:.|:.....::.:....:.|:.:.
Human   136 IEINSLHMVTEYNPVTVI------GLFN----SVIQIHLLLIMNKASPEYEENMHRYQKAAKLFQ 190

  Fly    72 GRILFGLRDISNIGEFNPNLNPDDFGSYRKGLPPRIYGKDCEGRVYDMHKL-------------- 122
            |:|||.|.| |.:.|                          .|:|....||
Human   191 GKILFILVD-SGMKE--------------------------NGKVISFFKLKESQLPALAIYQTL 228

  Fly   123 -----------VNAKYLREFCDQLLADQLFR 142
                       |:.::::.|||..|:.:|.:
Human   229 DDEWDTLPTAEVSVEHVQNFCDGFLSGKLLK 259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14695	NP_650032.1	Thioredoxin_6	<20..134	CDD:290560	23/140 (16%)
ERP27	NP_689534.1	Thioredoxin_6	64..250	CDD:372755	25/150 (17%)
		PDIA3-binding site. /evidence=ECO:0000269\|PubMed:16940051	230..233		0/2 (0%)
		Prevents secretion from ER. /evidence=ECO:0000305\|PubMed:16940051	270..273
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900