DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14695 and Pdia4

DIOPT Version :9

Sequence 1:	NP_650032.1	Gene:	CG14695 / 41314	FlyBaseID:	FBgn0037850	Length:	289	Species:	Drosophila melanogaster
Sequence 2:	NP_446301.2	Gene:	Pdia4 / 116598	RGDID:	619835	Length:	643	Species:	Rattus norvegicus

Alignment Length:	244	Identity:	45/244 - (18%)
Similarity:	81/244 - (33%)	Gaps:	100/244 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 SLLDELAQEYAGRILFGLRDISNIGEFNPNLNPDDFGS---------YRKG-LPPRIYG----KD 111
            ::|||..:::|                   :.|::|.|         ::|| |.|.|..    |:
  Rat   475 AILDESGKKFA-------------------MEPEEFDSDALREFVMAFKKGKLKPVIKSQPVPKN 520

  Fly   112 CEGRVYDMHKLVNAKYLREFCDQLLADQLFRAVVLGATASLDSKPMNYFELREESSSDMLVMLYD 176
            .:|.|                 :::..:.|.|:|:                  :...|:|:..|.
  Rat   521 NKGPV-----------------RVVVGKTFDAIVM------------------DPKKDVLIEFYA 550

  Fly   177 PACYYW----PIQKRMLRKLIRLLASEDLPIVIVDKANN------YLGVGFTRWLQMVNCHGSTI 231
            |.|.:.    |:...:.:|   ....:||.|..:|...|      |...||           .||
  Rat   551 PWCGHCKQLEPVYTSLGKK---YKGQKDLVIAKMDATANDITNDRYKVEGF-----------PTI 601

  Fly   232 FTSPRRDGWDIKLSVRMESTRGYLRYIARNRQPELIDFDADGEPRALEQ 280
            :.:|   ..|.|..::.|.....|.::::     .||..|....|..|:
  Rat   602 YFAP---SGDKKNPIKFEGGNRDLEHLSK-----FIDEHATKRSRTKEE 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14695	NP_650032.1	Thioredoxin_6	<20..134	CDD:290560	15/86 (17%)
Pdia4	NP_446301.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..58
		pdi_dom	65..166	CDD:273454
		CXXC. /evidence=ECO:0000250\|UniProtKB:P08003	89..92
		ER_PDI_fam	175..635	CDD:273457	43/235 (18%)
		CXXC. /evidence=ECO:0000250\|UniProtKB:P08003	553..556		1/2 (50%)
		Prevents secretion from ER	640..643		1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000292
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000