DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sodh-2 and SORD

DIOPT Version :9

Sequence 1:	NP_524311.1	Gene:	Sodh-2 / 41313	FlyBaseID:	FBgn0022359	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	NP_003095.2	Gene:	SORD / 6652	HGNCID:	11184	Length:	357	Species:	Homo sapiens

Alignment Length:	352	Identity:	195/352 - (55%)
Similarity:	258/352 - (73%)	Gaps:	3/352 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DNLTAVLHGIEDLRLEQRPIPEIADDEVLLAMDSVGICGSDVHYLAHGRIGDFVLTKPMIIGHEA 68
            :||:.|:||..|||||..||||...:||||.|.|||||||||||..:||||:|::.|||::||||
Human     8 NNLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGRIGNFIVKKPMVLGHEA 72

  Fly    69 AGVVAKLGKKVTTLKVGDRVAIEPGVPCRYCDHCKQGRYNLCADMVFCATPPYDGNLTRYYKHAA 133
            :|.|.|:|..|..||.|||||||||.|....:.||.|||||...:.||||||.||||.|:|||.|
Human    73 SGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMGRYNLSPSIFFCATPPDDGNLCRFYKHNA 137

  Fly   134 DFCFKLPDHVSMEEGALLEPLSVGVHACRRAGVGLGSKVLILGAGPIGLVTLLAAQAMGASEILI 198
            .||:||||:|:.|||||:||||||:|||||.||.||.|||:.||||||:||||.|:||||:::::
Human   138 AFCYKLPDNVTFEEGALIEPLSVGIHACRRGGVTLGHKVLVCGAGPIGMVTLLVAKAMGAAQVVV 202

  Fly   199 TDLVQQRLDVAKELGATHTLLLQRDQSAEETVKVVHQTMSEVPDKSIDCCGAESSARLAIFATRS 263
            |||...||..|||:||...|.:.: :|.:|..:.|...:...|:.:|:|.|||:|.:..|:||||
Human   203 TDLSATRLSKAKEIGADLVLQISK-ESPQEIARKVEGQLGCKPEVTIECTGAEASIQAGIYATRS 266

  Fly   264 GGVVVVVGMGAPEVKLPLINALAREIDIRGVFRYCNDYSAALALVASGKVNVKRLVTHHYDITET 328
            ||.:|:||:|:....:||::|..||:||:|||||||.:..|::::||..||||.||||.:.:.:.
Human   267 GGNLVLVGLGSEMTTVPLLHAAIREVDIKGVFRYCNTWPVAISMLASKSVNVKPLVTHRFPLEKA 331

  Fly   329 AEAFETSRRGTGGAIKVMIHVQPRDAN 355
            .|||||.::|.|  :|:|:...|.|.|
Human   332 LEAFETFKKGLG--LKIMLKCDPSDQN 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sodh-2	NP_524311.1	PLN02702	4..346	CDD:215378	191/341 (56%)
Sodh-2	NP_524311.1	sorbitol_DH	8..349	CDD:176188	190/340 (56%)
SORD	NP_003095.2	sorbitol_DH	11..350	CDD:176188	190/341 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144827
Domainoid	1	1.000	153	1.000	Domainoid score	I4289
eggNOG	1	0.900	-	-		E1_COG1063
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56080
Inparanoid	1	1.050	403	1.000	Inparanoid score	I1918
Isobase	1	0.950	-	0	Normalized mean entropy	S593
OMA	1	1.010	-	-		QHG56613
OrthoDB	1	1.010	-	-		D1019156at2759
OrthoFinder	1	1.000	-	-		FOG0001480
OrthoInspector	1	1.000	-	-		otm41911
orthoMCL	1	0.900	-	-		OOG6_100349
Panther	1	1.100	-	-	LDO	PTHR43161
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R311
SonicParanoid	1	1.000	-	-		X751
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750