DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sodh-2 and Sord

DIOPT Version :9

Sequence 1:	NP_524311.1	Gene:	Sodh-2 / 41313	FlyBaseID:	FBgn0022359	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	NP_666238.1	Gene:	Sord / 20322	MGIID:	98266	Length:	357	Species:	Mus musculus

Alignment Length:	352	Identity:	200/352 - (56%)
Similarity:	263/352 - (74%)	Gaps:	3/352 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DNLTAVLHGIEDLRLEQRPIPEIADDEVLLAMDSVGICGSDVHYLAHGRIGDFVLTKPMIIGHEA 68
            :||:.|:||..|:|||..||||:..::|||.|.|||||||||||..||||||||:.|||::||||
Mouse     8 ENLSLVVHGPGDIRLENYPIPELGPNDVLLKMHSVGICGSDVHYWEHGRIGDFVVKKPMVLGHEA 72

  Fly    69 AGVVAKLGKKVTTLKVGDRVAIEPGVPCRYCDHCKQGRYNLCADMVFCATPPYDGNLTRYYKHAA 133
            ||.|.|:|:.|..||.|||||||||||....::||.|||||...:.||||||.||||.|:|||.|
Mouse    73 AGTVTKVGELVKHLKPGDRVAIEPGVPREVDEYCKIGRYNLTPTIFFCATPPDDGNLCRFYKHNA 137

  Fly   134 DFCFKLPDHVSMEEGALLEPLSVGVHACRRAGVGLGSKVLILGAGPIGLVTLLAAQAMGASEILI 198
            |||:||||.|:.|||||:||||||::||||..|.||:|||:.||||:|:||||.|:||||:::::
Mouse   138 DFCYKLPDSVTFEEGALIEPLSVGIYACRRGSVSLGNKVLVCGAGPVGMVTLLVAKAMGAAQVVV 202

  Fly   199 TDLVQQRLDVAKELGATHTLLLQRDQSAEETVKVVHQTMSEVPDKSIDCCGAESSARLAIFATRS 263
            |||...||..|||:||..|:.:.: ::.:|....|...:...|:.:|:|.|||||.:..|:||.|
Mouse   203 TDLSASRLTKAKEVGADFTIQVGK-ETPQEIASKVESLLGSKPEVTIECTGAESSVQTGIYATHS 266

  Fly   264 GGVVVVVGMGAPEVKLPLINALAREIDIRGVFRYCNDYSAALALVASGKVNVKRLVTHHYDITET 328
            ||.:|:|||||..|.|||::|..||:||:|||||||.:..|::::||..:|||.||||.:.:.:.
Mouse   267 GGTLVIVGMGAEMVNLPLVHAAIREVDIKGVFRYCNTWPMAISMLASKTLNVKPLVTHRFPLEKA 331

  Fly   329 AEAFETSRRGTGGAIKVMIHVQPRDAN 355
            .|||||:::|.|  :||||...|.|.|
Mouse   332 VEAFETAKKGVG--LKVMIKCDPNDQN 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sodh-2	NP_524311.1	PLN02702	4..346	CDD:215378	194/341 (57%)
Sodh-2	NP_524311.1	sorbitol_DH	8..349	CDD:176188	195/340 (57%)
Sord	NP_666238.1	sorbitol_DH	11..350	CDD:176188	195/341 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834936
Domainoid	1	1.000	161	1.000	Domainoid score	I3996
eggNOG	1	0.900	-	-		E1_COG1063
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56080
Inparanoid	1	1.050	420	1.000	Inparanoid score	I1777
Isobase	1	0.950	-	0	Normalized mean entropy	S593
OMA	1	1.010	-	-		QHG56613
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001480
OrthoInspector	1	1.000	-	-		otm43959
orthoMCL	1	0.900	-	-		OOG6_100349
Panther	1	1.100	-	-	LDO	PTHR43161
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R311
SonicParanoid	1	1.000	-	-		X751
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740