Protein Alignment Fdh and AST1

DIOPT Version :10

• Sequence 1: NP_524310.1
• Gene: Fdh / 41311
• FlyBaseID: FBgn0011768
• Length: 379
• Species: Drosophila melanogaster
• Sequence 2: NP_009484.2
• Gene: AST1 / 852209
• SGDID: S000000165
• Length: 429
• Species: Saccharomyces cerevisiae
• Alignment Length: 427
• Identity: 82/427 - (19%)
• Similarity: 139/427 - (32%)
• Gaps: 142/427 - (33%)

  Fly    28 IEVAPPKAHEVRIKITATGVCHTDAFTLSGADPEGLFPVVLGHEGAGIVESVGEGVT-NFKAGDH 91
            |:...|| :::.::::..|:...|....:|........:.||.|.:|::..|||.:. .:..||.
Yeast    70 IKTPIPK-NKIVVRVSNVGLNPVDMKIRNGYTSSIYGEIGLGREYSGVITEVGENLNYAWHVGDE 133

  Fly    92 VIALYI-PQ----CNECKFCKSGKTNLCQKIRLTQGAGVMPEGTSRLSCKGQQLFHFMGTSTFAE 151
            |..:|. |.    |.:.......|.:   .|.|      .||..|.....| .||
Yeast   134 VYGIYYHPHLAVGCLQSSILVDPKVD---PILL------RPESVSAEEAAG-SLF---------- 178

  Fly   152 YTVVADISLTKINEKAPLEKVCLLGCGISTGYGAALNTAK---VEAGSTCAV-WGLGAVGLAV-- 210
                                 ||     :|||......:|   ::..|...: .|..:||:.|
Yeast   179 ---------------------CL-----ATGYNILNKLSKNKYLKQDSNVLINGGTSSVGMFVIQ 217

  Fly   211 ------GLGCKKAGAGKIYGIDINPDKF-ELAKKFGFTDFVNPK--------------------D 248
                  .|..|........|..:..:|| :||.:..|.|::..:                    .
Yeast   218 LLKRHYKLQKKLVIVTSANGPQVLQEKFPDLADEMIFIDYLTCRGKSSKPLRKMLEEKKISQYDP 282

  Fly   249 VADKGSIQNYLIDLTDGGFDYTFECIGNVNTMRSALEATHKGWGTSVVIG--VAGAGQEI----- 306
            |.||.:|.||    .:|.||...:.:|..:.:..:....|.|......:|  ||...::|
Yeast   283 VEDKETILNY----NEGKFDVVLDFVGGYDILSHSSSLIHGGGAYVTTVGDYVANYKEDIFDSWD 343

  Fly   307 --STRPFQLVVGRVWK--------------GSAFGGWRSVSDVPKLVE---DYLKKDLL------ 346
              |....::....:|.              .||...|         :|   |:||...:
Yeast   344 NPSANARKMFGSIIWSYNYTHYYFDPNAKTASANNDW---------IEQCGDFLKNGTVKCVVDK 399

  Fly   347 VDEFITHELPLSQINEAFDLM----HKGESIRSIIKY 379
            |.::..|:       |||..|    .:|:.|.::.|:
Yeast   400 VYDWKDHK-------EAFSYMATQRAQGKLIMNVEKF 429

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fdh	NP_524310.1	alcohol_DH_class_III	9..378	CDD:176260	81/424 (19%)
AST1	NP_009484.2	AST1_like	50..426	CDD:176209	81/422 (19%)