DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fdh and adh-5

DIOPT Version :9

Sequence 1:	NP_524310.1	Gene:	Fdh / 41311	FlyBaseID:	FBgn0011768	Length:	379	Species:	Drosophila melanogaster
Sequence 2:	NP_001024016.1	Gene:	adh-5 / 178597	WormBaseID:	WBGene00019240	Length:	386	Species:	Caenorhabditis elegans

Alignment Length:	383	Identity:	269/383 - (70%)
Similarity:	313/383 - (81%)	Gaps:	4/383 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSATEGKVITCKAAVAWEAKKPLVIEDIEVAPPKAHEVRIK--ITATGVCHTDAFTLSGADPEGL 63
            ||:|.|:||.|||||||.||.||.||.|:||||||||||:|  |..|.||||||:||.|.|||||
Worm     1 MSSTAGQVINCKAAVAWSAKAPLSIETIQVAPPKAHEVRVKFQILYTAVCHTDAYTLDGHDPEGL 65

  Fly    64 FPVVLGHEGAGIVESVGEGVTNFKAGDHVIALYIPQCNECKFCKSGKTNLCQKIRLTQGAGVMPE 128
            |||||||||:|||||||||||.|..||||:.||:|||.||::||:.|||||||||::||.|.||:
Worm    66 FPVVLGHEGSGIVESVGEGVTGFAPGDHVVPLYVPQCKECEYCKNPKTNLCQKIRISQGNGFMPD 130

  Fly   129 GTSRLSCKGQQLFHFMGTSTFAEYTVVADISLTKINEKAPLEKVCLLGCGISTGYGAALNTAKVE 193
            |:||.:|.|:|||||||.|||:||||||||||.|:|.:||||||.||||||||||||.|||.|||
Worm   131 GSSRFTCNGKQLFHFMGCSTFSEYTVVADISLCKVNPEAPLEKVSLLGCGISTGYGAVLNTCKVE 195

  Fly   194 AGSTCAVWGLGAVGLAVGLGCKKAGAGKIYGIDINPDKFELAKKFGFTDFVNPKDV--ADKGSIQ 256
            .|||.||||||||||||.:|.|.|||.||.|||:...|||.||.||.|:.:|||.|  .:..|.|
Worm   196 EGSTVAVWGLGAVGLAVIMGAKAAGAKKIVGIDLIESKFESAKFFGATECINPKSVELPEGKSFQ 260

  Fly   257 NYLIDLTDGGFDYTFECIGNVNTMRSALEATHKGWGTSVVIGVAGAGQEISTRPFQLVVGRVWKG 321
            .:|::..||||||||||||||:|||.||||.|||||.|.:||||||||||:|||||||.||.|||
Worm   261 AWLVEQFDGGFDYTFECIGNVHTMRQALEAAHKGWGVSCIIGVAGAGQEIATRPFQLVTGRTWKG 325

  Fly   322 SAFGGWRSVSDVPKLVEDYLKKDLLVDEFITHELPLSQINEAFDLMHKGESIRSIIKY 379
            :|||||:||..||:||:||:.|.||:||||||...:..||.|||::|||||:||::.:
Worm   326 TAFGGWKSVESVPRLVDDYMNKKLLIDEFITHRWNIDDINTAFDVLHKGESLRSVLAF 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fdh	NP_524310.1	FrmA	9..379	CDD:223990	264/373 (71%)
Fdh	NP_524310.1	alcohol_DH_class_III	9..378	CDD:176260	264/372 (71%)
adh-5	NP_001024016.1	FrmA	9..383	CDD:223990	264/373 (71%)
adh-5	NP_001024016.1	alcohol_DH_class_III	9..381	CDD:176260	264/371 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167820
Domainoid	1	1.000	177	1.000	Domainoid score	I2144
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68076
Inparanoid	1	1.050	562	1.000	Inparanoid score	I590
Isobase	1	0.950	-	0	Normalized mean entropy	S175
OMA	1	1.010	-	-		QHG63142
OrthoDB	1	1.010	-	-		D324108at33208
OrthoFinder	1	1.000	-	-		FOG0000360
OrthoInspector	1	1.000	-	-		oto20780
orthoMCL	1	0.900	-	-		OOG6_100471
Panther	1	1.100	-	-	LDO	PTHR43880
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R428
SonicParanoid	1	1.000	-	-		X1695
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.890