Protein Alignment Fdh and ADH6

DIOPT Version :10

• Sequence 1: NP_524310.1
• Gene: Fdh / 41311
• FlyBaseID: FBgn0011768
• Length: 379
• Species: Drosophila melanogaster
• Sequence 2: NP_001095940.1
• Gene: ADH6 / 130
• HGNCID: 255
• Length: 375
• Species: Homo sapiens
• Alignment Length: 375
• Identity: 190/375 - (50%)
• Similarity: 261/375 - (69%)
• Gaps: 3/375 - (0%)

  Fly     3 ATEGKVITCKAAVAWEAKKPLVIEDIEVAPPKAHEVRIKITATGVCHTDAFTLSGADPEGLFPVV 67
            :|.|:||.||||:.|:...|..||::|||||||.|||||:.|||:|.|:...|.....:.|:|.:
Human     2 STTGQVIRCKAAILWKPGAPFSIEEVEVAPPKAKEVRIKVVATGLCGTEMKVLGSKHLDLLYPTI 66

  Fly    68 LGHEGAGIVESVGEGVTNFKAGDHVIALYIPQCNECKFCKSGKTNLCQKIRLTQGAGVMPEGTSR 132
            |||||||||||:||||:..|.||.||.|::|||.||..|.:.:.|.|.:.:.:: ..:|.:||||
Human    67 LGHEGAGIVESIGEGVSTVKPGDKVITLFLPQCGECTSCLNSEGNFCIQFKQSK-TQLMSDGTSR 130

  Fly   133 LSCKGQQLFHFMGTSTFAEYTVVADISLTKINEKAPLEKVCLLGCGISTGYGAALNTAKVEAGST 197
            .:|||:.::||..||||.||||:.:||:.||:..||||||||:.||.|||:|||:|||||..|||
Human   131 FTCKGKSIYHFGNTSTFCEYTVIKEISVAKIDAVAPLEKVCLISCGFSTGFGAAINTAKVTPGST 195

  Fly   198 CAVWGLGAVGLAVGLGCKKAGAGKIYGIDINPDKFELAKKFGFTDFVNPKDVADKGSIQNYLIDL 262
            |||:|||.|||:|.:|||.|||.:|.|:|:|.:||:.|::.|.|:.:||:|:  |..||..|.|:
Human   196 CAVFGLGGVGLSVVMGCKAAGAARIIGVDVNKEKFKKAQELGATECLNPQDL--KKPIQEVLFDM 258

  Fly   263 TDGGFDYTFECIGNVNTMRSALEATHKGWGTSVVIGVAGAGQEISTRPFQLVVGRVWKGSAFGGW 327
            ||.|.|:.||.|||::.:.:||.:.::.:|..||:||..|..::.........||..|||.||||
Human   259 TDAGIDFCFEAIGNLDVLAAALASCNESYGVCVVVGVLPASVQLKISGQLFFSGRSLKGSVFGGW 323

  Fly   328 RSVSDVPKLVEDYLKKDLLVDEFITHELPLSQINEAFDLMHKGESIRSII 377
            :|...:||||.||:.:.|.:|..|||.|.|.:||||.:||..|:.||.|:
Human   324 KSRQHIPKLVADYMAEKLNLDPLITHTLNLDKINEAVELMKTGKCIRCIL 373

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fdh	NP_524310.1	alcohol_DH_class_III	9..378	CDD:176260	187/369 (51%)
ADH6	NP_001095940.1	alcohol_DH_class_I_II_IV	3..375	CDD:176259	190/374 (51%)