Protein Alignment Fdh and ADH4

DIOPT Version :9

• Sequence 1: NP_524310.1
• Gene: Fdh / 41311
• FlyBaseID: FBgn0011768
• Length: 379
• Species: Drosophila melanogaster
• Sequence 2: NP_001293100.1
• Gene: ADH4 / 127
• HGNCID: 252
• Length: 399
• Species: Homo sapiens
• Alignment Length: 376
• Identity: 212/376 - (56%)
• Similarity: 273/376 - (72%)
• Gaps: 8/376 - (2%)

  Fly     7 KVITCKAAVAWEAKKPLVIEDIEVAPPKAHEVRIKITATGVCHTDAFTLSGADPEGL-FPVVLGH 70
            :||.||||:||||.|||.||::||||||||||||:|.||.:||||| |:..:..||| |||::||
Human    25 QVIKCKAAIAWEAGKPLCIEEVEVAPPKAHEVRIQIIATSLCHTDA-TVIDSKFEGLAFPVIVGH 88

  Fly    71 EGAGIVESVGEGVTNFKAGDHVIALYIPQCNECKFCKSGKTNLCQKI-RLTQGAG---VMPEGTS 131
            |.||||||:|.||||.|.||.||.||.|.|.:||||.|..||||.|| .|...|.   :|.:.||
Human    89 EAAGIVESIGPGVTNVKPGDKVIPLYAPLCRKCKFCLSPLTNLCGKISNLKSPASDQQLMEDKTS 153

  Fly   132 RLSCKGQQLFHFMGTSTFAEYTVVADISLTKINEKAPLEKVCLLGCGISTGYGAALNTAKVEAGS 196
            |.:|||:.::||.|||||::||||:||:|.||::.|.||:|||||||.|||||||:|.|||..||
Human   154 RFTCKGKPVYHFFGTSTFSQYTVVSDINLAKIDDDANLERVCLLGCGFSTGYGAAINNAKVTPGS 218

  Fly   197 TCAVWGLGAVGLAVGLGCKKAGAGKIYGIDINPDKFELAKKFGFTDFVNPKDVADKGSIQNYLID 261
            ||||:|||.|||:..:|||.|||.:|.|||||.:||..||..|.||.:||:|:  ...||..:|:
Human   219 TCAVFGLGGVGLSAVMGCKAAGASRIIGIDINSEKFVKAKALGATDCLNPRDL--HKPIQEVIIE 281

  Fly   262 LTDGGFDYTFECIGNVNTMRSALEATHKGWGTSVVIGVAGAGQEISTRPFQLVVGRVWKGSAFGG 326
            ||.||.|:..:|.|...||::||:.|..|||:...||||...:.::..|.:|::||...|:.|||
Human   282 LTKGGVDFALDCAGGSETMKAALDCTTAGWGSCTFIGVAAGSKGLTIFPEELIIGRTINGTFFGG 346

  Fly   327 WRSVSDVPKLVEDYLKKDLLVDEFITHELPLSQINEAFDLMHKGESIRSII 377
            |:||..:||||.||..|...:|..:||.||..:|:||||||::|:|:|:|:
Human   347 WKSVDSIPKLVTDYKNKKFNLDALVTHTLPFDKISEAFDLMNQGKSVRTIL 397

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fdh	NP_524310.1	FrmA	9..379	CDD:223990	211/374 (56%)
		alcohol_DH_class_III	9..378	CDD:176260	211/374 (56%)
ADH4	NP_001293100.1	alcohol_DH_class_I_II_IV	25..399	CDD:176259	212/376 (56%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10984
eggNOG	1	0.900	-	-		E1_COG1062
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D324108at33208
OrthoFinder	1	1.000	-	-		FOG0000360
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100471
Panther	1	1.100	-	-	O	PTHR43880
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.780