Protein Alignment Fdh and ADH1A

DIOPT Version :10

• Sequence 1: NP_524310.1
• Gene: Fdh / 41311
• FlyBaseID: FBgn0011768
• Length: 379
• Species: Drosophila melanogaster
• Sequence 2: NP_000658.1
• Gene: ADH1A / 124
• HGNCID: 249
• Length: 375
• Species: Homo sapiens
• Alignment Length: 377
• Identity: 202/377 - (53%)
• Similarity: 267/377 - (70%)
• Gaps: 3/377 - (0%)

  Fly     3 ATEGKVITCKAAVAWEAKKPLVIEDIEVAPPKAHEVRIKITATGVCHTDAFTLSGADPEGLFPVV 67
            :|.||||.|||||.||.|||..||::|||||||||||||:.|.|:|.||...:||.....| ||:
Human     2 STAGKVIKCKAAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAVGICGTDDHVVSGTMVTPL-PVI 65

  Fly    68 LGHEGAGIVESVGEGVTNFKAGDHVIALYIPQCNECKFCKSGKTNLCQKIRLTQGAGVMPEGTSR 132
            ||||.||||||||||||..|.||.||.|.||||.:|:.||:.::|.|.|..::...|.:.:||||
Human    66 LGHEAAGIVESVGEGVTTVKPGDKVIPLAIPQCGKCRICKNPESNYCLKNDVSNPQGTLQDGTSR 130

  Fly   133 LSCKGQQLFHFMGTSTFAEYTVVADISLTKINEKAPLEKVCLLGCGISTGYGAALNTAKVEAGST 197
            .:|:.:.:.||:|.|||::||||.:.::.||:..:|||||||:|||.|||||:|:|.|||..|||
Human   131 FTCRRKPIHHFLGISTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGST 195

  Fly   198 CAVWGLGAVGLAVGLGCKKAGAGKIYGIDINPDKFELAKKFGFTDFVNPKDVADKGSIQNYLIDL 262
            |||:|||.|||:..:|||.|||.:|..:|||.|||..||:.|.|:.:||:|.  |..||..|.::
Human   196 CAVFGLGGVGLSAIMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDY--KKPIQEVLKEM 258

  Fly   263 TDGGFDYTFECIGNVNTMRSALEATHKGWGTSVVIGVAGAGQEISTRPFQLVVGRVWKGSAFGGW 327
            ||||.|::||.||.::||.::|...|:..||||::||....|.:|..|..|:.||.|||:..||:
Human   259 TDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPDSQNLSMNPMLLLTGRTWKGAILGGF 323

  Fly   328 RSVSDVPKLVEDYLKKDLLVDEFITHELPLSQINEAFDLMHKGESIRSIIKY 379
            :|...|||||.|::.|...:|..|||.||..:|||.|||:|.|:|||:|:.:
Human   324 KSKECVPKLVADFMAKKFSLDALITHVLPFEKINEGFDLLHSGKSIRTILMF 375

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fdh	NP_524310.1	alcohol_DH_class_III	9..378	CDD:176260	198/368 (54%)
ADH1A	NP_000658.1	alcohol_DH_class_I_II_IV	3..375	CDD:176259	202/374 (54%)