DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fdh and adh1a

DIOPT Version :9

Sequence 1:	NP_524310.1	Gene:	Fdh / 41311	FlyBaseID:	FBgn0011768	Length:	379	Species:	Drosophila melanogaster
Sequence 2:	XP_002934816.1	Gene:	adh1a / 100487939	XenbaseID:	XB-GENE-5929485	Length:	375	Species:	Xenopus tropicalis

Alignment Length:	374	Identity:	196/374 - (52%)
Similarity:	263/374 - (70%)	Gaps:	3/374 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TEGKVITCKAAVAWEAKKPLVIEDIEVAPPKAHEVRIKITATGVCHTDAFTLSGADPEGLFPVVL 68
            |.||||.||||:||...|||.||:|||||||||||||||.|:|:|.:|...|........||.:|
Frog     3 TTGKVIKCKAAIAWGLHKPLTIEEIEVAPPKAHEVRIKILASGICGSDLSVLKDKLSGVKFPTIL 67

  Fly    69 GHEGAGIVESVGEGVTNFKAGDHVIALYIPQCNECKFCKSGKTNLCQKIRLTQGAGVMPEGTSRL 133
            |||..|||||:|:.||..|.||..|.|::|||.:|:.||:...|:|:|...|...|:|.:.|||.
Frog    68 GHEAIGIVESIGKDVTVVKPGDKAIPLFVPQCGQCRACKTPNCNVCEKNDFTTKKGLMQDNTSRF 132

  Fly   134 SCKGQQLFHFMGTSTFAEYTVVADISLTKINEKAPLEKVCLLGCGISTGYGAALNTAKVEAGSTC 198
            :|||:|::|||.||||.|||||.||.:.|::..||:|. ||:|||.:||||||:|||||..||||
Frog   133 TCKGEQVYHFMSTSTFTEYTVVPDICVAKVDPAAPVEG-CLIGCGFATGYGAAVNTAKVTPGSTC 196

  Fly   199 AVWGLGAVGLAVGLGCKKAGAGKIYGIDINPDKFELAKKFGFTDFVNPKDVADKGSIQNYLIDLT 263
            ||:|||.||.:..:|||.||||:|.|:..:.|||..|.:.|.|:.::|||. || .||..:.|:|
Frog   197 AVFGLGGVGFSALIGCKIAGAGRIIGVGSHKDKFPKAIELGATECLSPKDY-DK-PIQEVIRDMT 259

  Fly   264 DGGFDYTFECIGNVNTMRSALEATHKGWGTSVVIGVAGAGQEISTRPFQLVVGRVWKGSAFGGWR 328
            :||.|:.|||.|.:.||::|.::|:.|.|.:||:||||....:|..|.:|:.||..|||||||::
Frog   260 NGGVDFAFECTGYIETMKTAFDSTYLGNGVTVVLGVAGPDDRLSFHPGELLFGRTMKGSAFGGFK 324

  Fly   329 SVSDVPKLVEDYLKKDLLVDEFITHELPLSQINEAFDLMHKGESIRSII 377
            |..:||.||.||::|...:|..::..:||.:|||||:||..|:.:|:||
Frog   325 SRDEVPMLVSDYMEKKFNLDFMVSERIPLEKINEAFELMQSGKGVRNII 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fdh	NP_524310.1	FrmA	9..379	CDD:223990	192/369 (52%)
Fdh	NP_524310.1	alcohol_DH_class_III	9..378	CDD:176260	192/369 (52%)
adh1a	XP_002934816.1	MDR	3..375	CDD:388358	196/374 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10681
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D324108at33208
OrthoFinder	1	1.000	-	-		FOG0000360
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43880
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020