DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fdh and Adh6b

DIOPT Version :9

Sequence 1:	NP_524310.1	Gene:	Fdh / 41311	FlyBaseID:	FBgn0011768	Length:	379	Species:	Drosophila melanogaster
Sequence 2:	NP_001357786.1	Gene:	Adh6b / 100417514	MGIID:	2446626	Length:	384	Species:	Mus musculus

Alignment Length:	376	Identity:	175/376 - (46%)
Similarity:	251/376 - (66%)	Gaps:	7/376 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TEGKVITCKAAVAWEAKKPLVIEDIEVAPPKAHEVRIKITATGVCHTDAFTLSG--ADPEGLFPV 66
            |...||.|:|||||....||.||::||.||||.|||:||.|:|:|.||..||.|  ..|   |||
Mouse    10 TSSNVIRCRAAVAWTTNAPLSIEEVEVDPPKAGEVRVKIIASGICGTDNHTLEGKMKTP---FPV 71

  Fly    67 VLGHEGAGIVESVGEGVTNFKAGDHVIALYIPQCNECKFCKSGKTNLCQKIRLTQGAGVMPEGTS 131
            :|||||||:|||||.|||..|.||.|:...:|:|.||.:|...|.|.|:|..:....|:|.:|||
Mouse    72 ILGHEGAGVVESVGPGVTTVKPGDKVLMFPLPECRECFYCLYPKGNFCEKENILSPTGLMLDGTS 136

  Fly   132 RLSCKGQQLFHFMGTSTFAEYTVVADISLTKINEKAPLEKVCLLGCGISTGYGAALNTAKVEAGS 196
            |.:|:|:::::.||||||.|||||.:|::.||...||::.||::.|.:.||:||..|||:|..||
Mouse   137 RFTCRGKKIYNIMGTSTFTEYTVVHEIAVAKIEAAAPMDTVCIMSCAVPTGFGAVFNTAQVTPGS 201

  Fly   197 TCAVWGLGAVGLAVGLGCKKAGAGKIYGIDINPDKFELAKKFGFTDFVNPKDVADKGSIQNYLID 261
            :|.|:|||.:|.|:.:.||.:||.:|.|:|||.:||..|:..|.||.:||..:  |..:|..:.:
Mouse   202 SCVVFGLGGIGSAIVMACKASGACRIIGVDINEEKFPRARALGVTDCLNPNKL--KKPVQEVVKE 264

  Fly   262 LTDGGFDYTFECIGNVNTMRSALEATHKGWGTSVVIGVAGAGQEISTRPFQLVVGRVWKGSAFGG 326
            :|..|.|:.||.||.:.||.:||::.::.:|..|::|||..|.::|..|..|:.||..|.|..||
Mouse   265 MTGVGVDFAFEAIGLIETMVAALKSCNRSYGVCVIMGVAPTGSQLSFDPLVLLPGRTLKSSVLGG 329

  Fly   327 WRSVSDVPKLVEDYLKKDLLVDEFITHELPLSQINEAFDLMHKGESIRSII 377
            :::..|:||||.||::|.:.:|..|||.||..:|||.|.|:.:|:.||.::
Mouse   330 YKTRDDIPKLVTDYVQKKINIDPLITHRLPFPKINEGFRLLQEGKCIRCVL 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fdh	NP_524310.1	FrmA	9..379	CDD:223990	173/371 (47%)
Fdh	NP_524310.1	alcohol_DH_class_III	9..378	CDD:176260	173/371 (47%)
Adh6b	NP_001357786.1	MDR	10..382	CDD:418376	175/376 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D324108at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43880
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020