DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tsp86D and Tspan33

DIOPT Version :9

Sequence 1:	NP_001262468.1	Gene:	Tsp86D / 41310	FlyBaseID:	FBgn0037848	Length:	316	Species:	Drosophila melanogaster
Sequence 2:	NP_001102697.1	Gene:	Tspan33 / 500065	RGDID:	1560915	Length:	283	Species:	Rattus norvegicus

Alignment Length:	298	Identity:	119/298 - (39%)
Similarity:	178/298 - (59%)	Gaps:	26/298 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 STYPHHFSYVSSCVKYMIFLLNFLFWLFGGLLLAIGVYAFMDKLMDGN-GWLRLDTIYDVIFNIS 81
            :.|...||:||..|||::|..|.|||:...:::|:||||.:.|..:.. ..|.:|.        :
  Rat     9 AAYGEEFSFVSPLVKYLLFFFNMLFWVISMVMVAVGVYARLMKHAEAALACLAVDP--------A 65

  Fly    82 LVMIIAGVIVFTVSFAGCLGALRENTWLLKLYSMCLLLFFILEMSLAIICFVFPQYMNSFLEYQF 146
            :::|:.||::|.::|.||:|:||||..||:.:|:||.:.|:|:::..|:.|||.......:....
  Rat    66 ILLIVVGVLMFLLTFCGCIGSLRENICLLQTFSLCLTIVFLLQLAAGILGFVFSDKARGKVSEII 130

  Fly   147 TDKIIHSYRDDSDLQNFIDFAQQEFNCCGLSNAGYQDWSKNEYFNCS--SPSVERCGVPYSCCIN 209
            .:.|:| ||||.||||.|||.|::|:|||  ...|:|||:|.|||||  :||.|||.||||||:.
  Rat   131 NNAIVH-YRDDLDLQNLIDFGQKKFSCCG--GISYRDWSQNMYFNCSEDNPSRERCSVPYSCCLP 192

  Fly   210 ATDISSGLVNIMCGYGVQVRSVAAASKRIWTSGCIEIVRVWVERNLYVIAGVALGIALLQLFVIY 274
            ..  :..::|.|||.|:|......|||.|:|:|||:.:..|:..||:::.|||||:|:.||..|.
  Rat   193 TP--NQAVINTMCGQGMQALDYLEASKVIYTNGCIDKLVNWIHSNLFLLGGVALGLAIPQLVGIL 255

  Fly   275 LAKTLEGQIDLQKSRWSXVQCHHPYLYGYPPCEDDPYY 312
            |::.|..||..|.......|.|..          ||:|
  Rat   256 LSQVLVNQIKDQIKLQLYNQQHRA----------DPWY 283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsp86D	NP_001262468.1	Tetraspannin	51..283	CDD:278750	98/234 (42%)
Tsp86D	NP_001262468.1	penumbra_like_LEL	132..255	CDD:239411	57/124 (46%)
Tspan33	NP_001102697.1	penumbra_like_LEL	116..236	CDD:239411	57/124 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	208	1.000	Domainoid score	I2760
eggNOG	1	0.900	-	-		E1_KOG3882
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8213
Inparanoid	1	1.050	222	1.000	Inparanoid score	I3449
OMA	1	1.010	-	-		QHG48585
OrthoDB	1	1.010	-	-		D1416189at2759
OrthoFinder	1	1.000	-	-		FOG0003557
OrthoInspector	1	1.000	-	-		otm44842
orthoMCL	1	0.900	-	-		OOG6_108299
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X349
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.780