DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tsp86D and tspan33a

DIOPT Version :9

Sequence 1:	NP_001262468.1	Gene:	Tsp86D / 41310	FlyBaseID:	FBgn0037848	Length:	316	Species:	Drosophila melanogaster
Sequence 2:	NP_001002617.2	Gene:	tspan33a / 436890	ZFINID:	ZDB-GENE-040718-361	Length:	281	Species:	Danio rerio

Alignment Length:	290	Identity:	110/290 - (37%)
Similarity:	174/290 - (60%)	Gaps:	25/290 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 FSYVSSCVKYMIFLLNFLFWLFGGLLLAIGVYAFMDKLMDGNGWLRLDTIYDVIFNISLVMIIAG 88
            :::||..|||::|..|.:||:...:|::||||:.:.|.......|.:|.        :|::::.|
Zfish    14 YTFVSPVVKYLLFFFNMIFWIISLVLISIGVYSRIVKHETALACLTVDP--------ALILMVVG 70

  Fly    89 VIVFTVSFAGCLGALRENTWLLKLYSMCLLLFFILEMSLAIICFVFPQYMNSFLEYQFTDKIIHS 153
            :::|.::|.||:|:||||..||:.:.:.|.:.|:|::...::.|||.......:...|.:.|.|
Zfish    71 ILMFFITFCGCVGSLRENICLLQTFCIFLTIMFLLQLLAGVLGFVFSDKARGKVTDMFDNAIKH- 134

  Fly   154 YRDDSDLQNFIDFAQQEFNCCGLSNAGYQDWSKNEYFNCS--SPSVERCGVPYSCCINATDISSG 216
            ||||.||||.||:.|::|||||  ...:.|||||.|||||  :||.|||.||:|||::|.:  ..
Zfish   135 YRDDLDLQNLIDYGQKQFNCCG--GISFMDWSKNMYFNCSDDNPSRERCSVPFSCCLHAKE--ET 195

  Fly   217 LVNIMCGYGVQVRSVAAASKRIWTSGCIEIVRVWVERNLYVIAGVALGIALLQLFVIYLAKTLEG 281
            ::|.|||:|:|..:..|||..|.|:|||:|:..|:..||:::.|:|||:.:.||..|.|::.|..
Zfish   196 IINTMCGHGMQALNYLAASAFINTNGCIDILVNWIHSNLFLLGGIALGLTIPQLVGILLSQVLIN 260

  Fly   282 QIDLQKSRWSXVQCHHPYLYGYPPCEDDPY 311
            ||..|....: .|.|          ..||:
Zfish   261 QIQDQIKLQNYNQQH----------RSDPW 280

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsp86D	NP_001262468.1	Tetraspannin	51..283	CDD:278750	93/233 (40%)
Tsp86D	NP_001262468.1	penumbra_like_LEL	132..255	CDD:239411	59/124 (48%)
tspan33a	NP_001002617.2	Tetraspannin	21..262	CDD:278750	101/253 (40%)
tspan33a	NP_001002617.2	penumbra_like_LEL	114..234	CDD:239411	59/124 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3882
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8213
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48585
OrthoDB	1	1.010	-	-		D1416189at2759
OrthoFinder	1	1.000	-	-		FOG0003557
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_108299
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6362
SonicParanoid	1	1.000	-	-		X349
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.760