DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tsp86D and Prph2

DIOPT Version :9

Sequence 1:	NP_001262468.1	Gene:	Tsp86D / 41310	FlyBaseID:	FBgn0037848	Length:	316	Species:	Drosophila melanogaster
Sequence 2:	NP_037153.1	Gene:	Prph2 / 25534	RGDID:	3549	Length:	346	Species:	Rattus norvegicus

Alignment Length:	284	Identity:	74/284 - (26%)
Similarity:	123/284 - (43%)	Gaps:	63/284 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 IFLLNFLFWLFGGLLLAIGVYAFMDKLMDGNGWLRLDTIYDVIFN-----ISLVMIIAGVI--VF 92
            ::|:|:|..|.|.:|.::|::..::        ||..:  ||:.|     :...:|..||:  ||
  Rat    20 LWLMNWLSVLAGIVLFSLGLFLKIE--------LRKRS--DVMDNSESHFVPNSLIGVGVLSCVF 74

  Fly    93 TVSFAG--CLGAL------RENTWLLKLYSMCLLLFFILEMSLAIICFVFPQYMNSFLEYQFTDK 149
            . |.||  |..||      :...| ||||....:.|.::...:|:.||:....:.|.|.|...:.
  Rat    75 N-SLAGKICYDALDPAKYAKWKPW-LKLYLAVCVFFNVILFLVALCCFLLRGSLESTLAYGLKNG 137

  Fly   150 IIHSYRDDSD-----LQNFIDFAQQEFNCCGLSNAGYQDWSK-----NEYFNCSSPSV-ERC--- 200
            :.: |||...     ::..||..|.||.|||  |.|::||.:     |.|.:.||..| :|.
  Rat   138 MKY-YRDTDTPGRCFMKKTIDMLQIEFKCCG--NNGFRDWFEIQWISNRYLDFSSKEVKDRIKSN 199

  Fly   201 --------GVPYSCCINATD---ISSGLVNIMCGYGVQVRSVAAASKRIWTSGCIEIVRVWVERN 254
                    |||:|||..::.   |...|.|....|....::   ....:|..||...:     .|
  Rat   200 VDGRYLVDGVPFSCCNPSSPRPCIQYQLTNNSAHYSYDHQT---EELNLWLRGCRAAL-----LN 256

  Fly   255 LYVIAGVALGIALLQLFVIYLAKT 278
            .|.....::|:..|.:::..::.|
  Rat   257 YYSSLMNSMGVVTLLIWLFEVSIT 280

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsp86D	NP_001262468.1	Tetraspannin	51..283	CDD:278750	68/268 (25%)
Tsp86D	NP_001262468.1	penumbra_like_LEL	132..255	CDD:239411	38/147 (26%)
Prph2	NP_037153.1	Tetraspannin	20..277	CDD:278750	73/279 (26%)
		TDT	58..>123	CDD:296283	20/66 (30%)
		peripherin_like_LEL	120..262	CDD:239415	40/152 (26%)
		Interaction with MREG. /evidence=ECO:0000250	341..346
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910