DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14694 and slc19a3a

DIOPT Version :9

Sequence 1:	NP_650028.1	Gene:	CG14694 / 41307	FlyBaseID:	FBgn0037845	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	XP_686091.3	Gene:	slc19a3a / 557854	ZFINID:	ZDB-GENE-110411-41	Length:	501	Species:	Danio rerio

Alignment Length:	490	Identity:	142/490 - (28%)
Similarity:	248/490 - (50%)	Gaps:	54/490 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MESWLKISCLLCIFGFLRELRPSEPYHAEILMGEWYHVTQDEVNRSVYPVGTYSYLALLIFVFLI 65
            |:.|...:.||.|:||...::|.||:....|.|...::|.:::|..::||.||||||:|:.|||:
Zfish     8 MKDWKYPTSLLFIYGFFSTVKPLEPFLYPFLTGPDKNLTTEQLNNQIFPVWTYSYLAVLVPVFLL 72

  Fly    66 TDLLRYKPVIIANATTGICIWGTLIWTTTLSGLQAVEVFYGFYQAGEVAYYSYIYAKVDKQYYPR 130
            ||.||||||::..:....|....|:|...:..:||::..||...:.:|||::|||:.|:.::|.:
Zfish    73 TDWLRYKPVVVFQSLILFCTTSMLLWCNGVPEMQAMQFTYGVVTSCDVAYFTYIYSMVEIKHYLK 137

  Fly   131 VTSHTRAAMFVGKLVAGILAQMVIGMRWMNYKQLFYITVTSQVAALLWAFFLPKVEKSLYFHNR- 194
            .||:.|.|..:|..|..:|.|:::.:..|:|..:...|:.....|::.:..||..:.|::||.:
Zfish   138 ATSYCRTAHLLGYTVGSVLGQILVSLELMSYNNILVFTLVLTGIAMIASILLPMPKVSMFFHKKQ 202

  Fly   195 -----SEAIEGGTKS-----------------------------DGGNLEKGSEQPSNEEASQEK 225
                 :|...|..|.                             ||.|   |.:..|.:.:...:
Zfish   203 SEEDDNEGHSGNVKPLEPEEGFGTMVDLSNDVKVDETKWQQDVLDGSN---GCDSSSAKSSKSSR 264

  Fly   226 KI---PALQLLWSHFRSAYTNPLVIQWSLWYAISLAGFLQITTYMQVVWKSFENEPTI-AWNGAV 286
            |.   ..|..||..|...:::..::.||.|:|::..|:.|...|:|.:|:..|..... .:||..
Zfish   265 KAGCGDVLLRLWRDFLQCFSSRTLLLWSAWWALATCGYNQTVNYVQSLWEHVEPSSNFTVYNGGA 329

  Fly   287 DVALTLLSAVFALLAGYFHAGRLNTRSSLLSMALLSVLEGGCVLLSCWTDDIYLSYLGYVLYGGL 351
            :....|..|..|...|...|..  :|...::::.||.||||.:....::.:|::.|.||:|:..|
Zfish   330 EALSNLFGAAAAYGIGLSSADW--SRWGEMALSALSALEGGALFAMVFSGNIWVCYGGYILFKSL 392

  Fly   352 FAFTITVASSELASSLEEDSFALVFGFNTFVGLLLQCILTFVVVSEKANLNLNVFQQFSVYAFYF 416
            :...||:|..::|:.|..:.:|||||.|||..|:||.|:|.|||..: .|.::|..||.:...||
Zfish   393 YMLLITIAMFQIAAGLNMERYALVFGANTFCALVLQTIITSVVVDSR-GLGVDVVTQFIINGAYF 456

  Fly   417 IVIGIVYSIAVILQYIWSISKKPKA------IQEA 445
            .||.:::.:..:..   ::.:||:.      ::||
Zfish   457 SVIAVIFFLRGLYT---TMCRKPETDTSRENLEEA 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14694	NP_650028.1	Folate_carrier	2..411	CDD:280024	133/447 (30%)
slc19a3a	XP_686091.3	Folate_carrier	9..451	CDD:280024	133/447 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580834
Domainoid	1	1.000	270	1.000	Domainoid score	I1781
eggNOG	1	0.900	-	-		E1_KOG3810
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H23530
Inparanoid	1	1.050	284	1.000	Inparanoid score	I2845
OMA	1	1.010	-	-		QHG56145
OrthoDB	1	1.010	-	-		D344994at33208
OrthoFinder	1	1.000	-	-		FOG0001487
OrthoInspector	1	1.000	-	-		mtm6477
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10686
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X476
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.870