DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14694 and slc19a3b

DIOPT Version :9

Sequence 1:	NP_650028.1	Gene:	CG14694 / 41307	FlyBaseID:	FBgn0037845	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	XP_005159318.1	Gene:	slc19a3b / 556920	ZFINID:	ZDB-GENE-050419-166	Length:	498	Species:	Danio rerio

Alignment Length:	454	Identity:	143/454 - (31%)
Similarity:	243/454 - (53%)	Gaps:	43/454 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 WLKISCLLCIFGFLRELRPSEPYHAEILMGEWYHVTQDEVNRSVYPVGTYSYLALLIFVFLITDL 68
            |:..:.||.::||....||:||:....|:|. .:::::.|...::|:.|||||:||..|||:|||
Zfish    12 WVFPTVLLSLYGFFANCRPAEPFLTPYLVGP-KNISEEVVTNYLFPIWTYSYLSLLCPVFLLTDL 75

  Fly    69 LRYKPVIIANATTGICIWGTLIWTTTLSGLQAVEVFYGFYQAGEVAYYSYIYAKVDKQYYPRVTS 133
            |||||:|:|.....:..:..|.:..:|..|..::..:....:.||||:||||:.:..:.|.|.|.
Zfish    76 LRYKPLIVAQGLFLVTNYIILSFANSLPALTYLQFNFAVVTSTEVAYFSYIYSVIPPERYQRATG 140

  Fly   134 HTRAAMFVGKLVAGILAQMVIGMRWMNYKQLFYITVTSQVAALLWAFFLPKVEKSLYFHNR---- 194
            :.|:||..|.....||.||:|.:...:|..:..:|::..:.||..:..||..:..::|..:
Zfish   141 YVRSAMLAGYTFGAILGQMLISLANTSYFHVNTVTLSLMIVALCISLSLPMPQHGVFFKKKQVEV 205

  Fly   195 -----SEAIEGGTKSDGGNLEKGSEQPSNEEASQEKKI-----PALQLLWSHFRSAYTNPLVIQW 249
                 :|..:||:..|   |||       |...:..||     .:.:.:|...:.:|::..::||
Zfish   206 SMDTMNEVADGGSSRD---LEK-------EVTGRSVKICEYIKTSGKQMWESLKESYSSRRLVQW 260

  Fly   250 SLWYAISLAGFLQITTYMQVVWKSFENEPTIA-WNGAVDVALTLLSAVFALLAGYFHA-----GR 308
            |||:|::.||:.|:..|:|::|...|...|.: :||.|:....|:.|..|...||...     |.
Zfish   261 SLWWALATAGYGQVFNYVQLMWDHIEPSSTSSVYNGGVEAVCALVGAAAAFSVGYIQVQWGVWGE 325

  Fly   309 LNTRSSLLSMALLSVLEGGCVLLSCWTDDIYLSYLGYVLYGGLFAFTITVASSELASSLEEDSFA 373
                   ||:.:.|.:..|||.|...|:.|:|||.||.::...:.|.||:...::|.:|..:.:|
Zfish   326 -------LSLGVFSAVGAGCVFLMGLTNSIWLSYAGYAIFKASYMFLITITMFQIAVNLSMECYA 383

  Fly   374 LVFGFNTFVGLLLQCILTFVVVSEKANLNLNVFQQFSVYAFYFIVIGIVYSIAVILQYIWSISK 437
            |.||.|:||.|.||.|||.:||...| |.|::..||.||..|:.:|.:::    ::|.::::.|
Zfish   384 LTFGINSFVALTLQTILTAIVVDNTA-LGLDIATQFLVYGGYYSIISVLF----LIQGLYTVCK 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14694	NP_650028.1	Folate_carrier	2..411	CDD:280024	137/426 (32%)
slc19a3b	XP_005159318.1	Folate_carrier	10..420	CDD:280024	137/426 (32%)
slc19a3b	XP_005159318.1	MFS_1	33..392	CDD:284993	114/376 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580837
Domainoid	1	1.000	270	1.000	Domainoid score	I1781
eggNOG	1	0.900	-	-		E1_KOG3810
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	284	1.000	Inparanoid score	I2845
OMA	1	1.010	-	-		QHG56145
OrthoDB	1	1.010	-	-		D344994at33208
OrthoFinder	1	1.000	-	-		FOG0001487
OrthoInspector	1	1.000	-	-		mtm6477
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10686
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X476
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.870