DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14694 and Slc19a3

DIOPT Version :9

Sequence 1:	NP_650028.1	Gene:	CG14694 / 41307	FlyBaseID:	FBgn0037845	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	XP_038939614.1	Gene:	Slc19a3 / 316559	RGDID:	1311413	Length:	485	Species:	Rattus norvegicus

Alignment Length:	461	Identity:	150/461 - (32%)
Similarity:	251/461 - (54%)	Gaps:	30/461 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ESWLKISCLLCIFGFLRELRPSEPYHAEILMGEWYHVTQDEVNRSVYPVGTYSYLALLIFVFLIT 66
            :||:..:.:||:|||....||||.:....|.|...::|..|:...:.||.||||||:|..||::|
  Rat    13 DSWVYPTVILCLFGFFSMFRPSESFLIPFLSGPSKNLTSTEMTNEILPVWTYSYLAMLPPVFVLT 77

  Fly    67 DLLRYKPVIIANATTGICIWGTLIWTTTLSGLQAVEVFYGFYQAGEVAYYSYIYAKVDKQYYPRV 131
            |.|||||:|:.:.......:..|::..::..:|..|.|:|...|.|:||::|||:.|..::|.:|
  Rat    78 DYLRYKPIIMLHVMAFTICYLFLLFGQSVMLMQTAEFFFGIVSATEIAYFAYIYSMVSPEHYQKV 142

  Fly   132 TSHTRAAMFVGKLVAGILAQMVIGMRWMNYKQLFYITVTSQVAALLWAFFLPKVEKSLYFH---N 193
            :|:.|:...|......:|||:::.:..:.|..||||::.....|...:.|||..:||::||   |
  Rat   143 SSYCRSITLVSYTAGSVLAQLLVSLMNVPYSTLFYISLACVSVAFFVSLFLPMPKKSMFFHTKPN 207

  Fly   194 RS---EAIEGGT-----KSDGGNLEKGSEQPSNEEASQEKKIPALQLLW-SHFRSAYTNPLVIQW 249
            |.   :.:|..|     .::|...|..:...:..:..|:.....:.:.| ...:..|::..::.|
  Rat   208 REACPKPLEPCTVLKEAHNNGAQPELFANAQNLGDREQDNSALRIFVYWFQDLKECYSSKHLVYW 272

  Fly   250 SLWYAISLAGFLQITTYMQVVW--KSFENEPTIAWNGAVDVALTLLSAVFALLAGYFHA-----G 307
            |||:|.:.||:.||..::||:|  |:...:.:| :||||:...|...|:.:...||...     |
  Rat   273 SLWWAFATAGYNQILNFVQVLWEQKAPSKDSSI-YNGAVEAIATFGGALASFSVGYIKVDWDLLG 336

  Fly   308 RLNTRSSLLSMALLSVLEGGCVLLSCWTDDIYLSYLGYVLYGGLFAFTITVASSELASSLEEDSF 372
            .       |.:|:.|.:..|.:||..:|..|::.|.||||....::|.||:|..::|.:|..:.:
  Rat   337 E-------LGLAVFSAVVAGSLLLMNYTLSIWVCYTGYVLVKSSYSFLITIAVFQIAVNLSLERY 394

  Fly   373 ALVFGFNTFVGLLLQCILTFVVVSEKANLNLNVFQQFSVYAFYFIVIGIVYSIAVILQYIWSISK 437
            |||||.:||:.|::|.|:| ::|:::..|.|.|..||.||..||.||..|:.|..|  ||...:|
  Rat   395 ALVFGIDTFIALVIQTIMT-MIVADQRGLQLPVTTQFLVYGSYFAVIAGVFLIRSI--YILYSAK 456

  Fly   438 KPKAIQ 443
            ..|.:|
  Rat   457 CRKEVQ 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14694	NP_650028.1	Folate_carrier	2..411	CDD:280024	136/427 (32%)
Slc19a3	XP_038939614.1	Folate_carrier	14..432	CDD:396365	136/426 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340958
Domainoid	1	1.000	260	1.000	Domainoid score	I1900
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H23530
Inparanoid	1	1.050	283	1.000	Inparanoid score	I2792
OMA	1	1.010	-	-		QHG56145
OrthoDB	1	1.010	-	-		D344994at33208
OrthoFinder	1	1.000	-	-		FOG0001487
OrthoInspector	1	1.000	-	-		mtm8947
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10686
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X476
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.010