DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14694 and Slc19a1

DIOPT Version :9

Sequence 1:	NP_650028.1	Gene:	CG14694 / 41307	FlyBaseID:	FBgn0037845	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	NP_001030309.1	Gene:	Slc19a1 / 29723	RGDID:	3695	Length:	512	Species:	Rattus norvegicus

Alignment Length:	430	Identity:	142/430 - (33%)
Similarity:	244/430 - (56%)	Gaps:	21/430 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MESWLKISCLLCIFGFLRELRPSEPYHAEILMGEWYHVTQDEVNRSVYPVGTYSYLALLIFVFLI 65
            ::||..:...||.|||:.:|||.|.:....|:..  :.|:::|...:.|:..||:||:|:.:||:
  Rat    22 LKSWRWLVFYLCFFGFMAQLRPGESFITPYLLER--NFTKEQVTNEIIPMLPYSHLAVLVPIFLL 84

  Fly    66 TDLLRYKPVIIANATTGICIWGTLIWTTTLSGLQAVEVFYGFYQAGEVAYYSYIYAKVDKQYYPR 130
            ||.||||||::....:.:|:|..|:..|::..:|.:||||....|..:||.|||::.|....|.|
  Rat    85 TDYLRYKPVLVLQCLSFVCVWLLLLLGTSVVHMQLMEVFYSITMAARIAYSSYIFSLVQPSRYQR 149

  Fly   131 VTSHTRAAMFVGKLVAGILAQMVIGMRWMNYKQLFYITVTSQVAALLWAFFLPKVEKSLYFHNRS 195
            :.|::|||:.:|..::.:|.|:::.:..::...|..|::...:.:|..:.||.:.::||:| |||
  Rat   150 MASYSRAAVLLGVFISSVLGQVLVTLGGISTYMLNCISLGFILFSLSLSLFLKRPKRSLFF-NRS 213

  Fly   196 EAIEGGTKSDGGNLEKGSEQPSNEEASQEKKIPA-----LQLLWSHFRSAYTNPLVIQWSLWYAI 255
            ..::|....:...:..|..:|  |....|:.:..     |..:.|........|.:..|.||:..
  Rat   214 ALVQGALPCELDQMHPGPGRP--EPRKLERMLGTCRDSFLVRMLSELVKNVRQPQLRLWCLWWVF 276

  Fly   256 SLAGFLQITTYMQVVWKSFENEPTIAWNGAVDVALTLLSAVFALLAGYFHAGRLNTRSSL---LS 317
            :.||:..||.|:.|:||..::.  :.:|||||.|.|||||:.|..||:     :|.|.:|   |.
  Rat   277 NSAGYYLITYYVHVLWKITDSR--LNYNGAVDAASTLLSAITAFTAGF-----VNIRWALWSKLV 334

  Fly   318 MALLSVLEGGCVLLSCWTDDIYLSYLGYVLYGGLFAFTITVASSELASSLEEDSFALVFGFNTFV 382
            :|.:..::.|.|.......||::.|:.:||:.|.:.|.:.:|:.::||||.::..|||||.|||:
  Rat   335 IASVIAIQAGLVFCMFQIPDIWVCYVTFVLFRGAYQFLVPIATFQIASSLSKELCALVFGINTFL 399

  Fly   383 GLLLQCILTFVVVSEKANLNLNVFQQFSVYAFYFIVIGIV 422
            ...|:..:| :|||:|..|.|.|.|||.:|..||:.:.|:
  Rat   400 ATALKTSIT-LVVSDKRGLGLQVHQQFRIYFMYFLTLSII 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14694	NP_650028.1	Folate_carrier	2..411	CDD:280024	138/416 (33%)
Slc19a1	NP_001030309.1	rfc	1..512	CDD:129888	142/430 (33%)
		Required for substrate-binding. /evidence=ECO:0000250\|UniProtKB:P41440	400..412		3/12 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	479..512
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340952
Domainoid	1	1.000	260	1.000	Domainoid score	I1900
eggNOG	1	0.900	-	-		E1_KOG3810
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56145
OrthoDB	1	1.010	-	-		D344994at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8947
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10686
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X476
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.860