DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14694 and folt-2

DIOPT Version :9

Sequence 1:	NP_650028.1	Gene:	CG14694 / 41307	FlyBaseID:	FBgn0037845	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	NP_503780.1	Gene:	folt-2 / 178745	WormBaseID:	WBGene00018138	Length:	424	Species:	Caenorhabditis elegans

Alignment Length:	447	Identity:	155/447 - (34%)
Similarity:	239/447 - (53%)	Gaps:	46/447 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MESWLKISCLLCIFGFLRELRPSEPYHAEILMGEWYH----VTQDEVNRSVYPVGTYSYLALLIF 61
            ||.| |:..|:|::|.::|.||:|||     |.|:.|    :::..:|..|||:.|||||..||.
Worm     1 MEQW-KVMVLICMYGAVKEFRPTEPY-----MYEYQHTVLNMSEQTLNSQVYPIWTYSYLITLIP 59

  Fly    62 VFLITDLLRYKPVIIANATTGICIWGTLIWTTTLSGLQAVEVFYGFYQAGEVAYYSYIYAKVDKQ 126
            .||:||:..|||:::..|.:....|...::..::...|.:|||||:..|.|:||::|||.||.|.
Worm    60 AFLLTDVFLYKPLLVFEAFSYFLCWVIFVFGKSVWSQQVLEVFYGWATATEIAYFAYIYVKVPKT 124

  Fly   127 YYPRVTSHTRAAMFVGKLVAGILAQMVIGMRWMNYKQLFYITVTSQVAALLWAFFLPKVEKSLYF 191
            .|...|:.||||:.||:.:|..|||::||:.|.:|..|..|::.:...|:..|..||.||
Worm   125 EYKSATAFTRAALLVGRFLAYALAQLLIGLNWTSYSTLNIISLVAMTIAVFLALILPGVE----- 184

  Fly   192 HNRSEAIEGGTKSDG--GNLEKGSEQPSNEEASQEKKIPALQLLWSHFR----SAYTNPLVIQWS 250
              ..||.|...:.:.  |||:        |...|...:..|::.:...|    :.|.|||:::||
Worm   185 --WKEAYEKKLEDNNVQGNLK--------EIVDQSSYMDYLRMFFVGLRHNLMAIYRNPLILKWS 239

  Fly   251 LWYAISLAGFLQITTYMQVVWKSFENEPTIAWNGAVDVALTLLSAVFALLAGYFHAGRLN---TR 312
            :|.|:|...|.|:|.|.|.:|.:.. |....:||..:..:.||.....|:     ..:||   .|
Worm   240 VWSALSSCIFYQVTNYTQTLWGTLP-ESANRYNGITEALVPLLGIPADLI-----TRQLNVNWNR 298

  Fly   313 SSLLSMALLSVLEGGCVLLSCWTDDIYLSYLGYVLYGGLFAFTITVASSELASSLEEDSFALVFG 377
            ...|.:|:.|:.:.|.:.....:..|.:.||.|:.|..::..|.|:|.|.||.||:...|.|:||
Worm   299 WGDLLLAVGSIGQAGLLFWMSQSHHIVVLYLSYIFYRVIYQLTTTIAQSTLAFSLDSRLFGLLFG 363

  Fly   378 FNTFVGLLLQCILTFVVVSEKANLNLNVFQQFSVYAFYFIVIGIVYSIAVILQYIWS 434
            .||||.||||.|||.||:..:   .|::..||.||:.|.:|  :.:..|:|.. ||:
Worm   364 INTFVALLLQSILTAVVIDWQ---KLDIRPQFVVYSCYHLV--VAFGFAIIFG-IWA 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14694	NP_650028.1	Folate_carrier	2..411	CDD:280024	146/421 (35%)
folt-2	NP_503780.1	rfc	1..424	CDD:129888	155/447 (35%)
folt-2	NP_503780.1	Folate_carrier	2..394	CDD:280024	146/421 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159420
Domainoid	1	1.000	262	1.000	Domainoid score	I1036
eggNOG	1	0.900	-	-		E1_KOG3810
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I1812
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56145
OrthoDB	1	1.010	-	-		D344994at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm4762
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10686
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R17024
SonicParanoid	1	1.000	-	-		X476
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.900