DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14694 and Slc19a2

DIOPT Version :9

Sequence 1:	NP_650028.1	Gene:	CG14694 / 41307	FlyBaseID:	FBgn0037845	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	NP_473428.1	Gene:	Slc19a2 / 116914	MGIID:	1928761	Length:	498	Species:	Mus musculus

Alignment Length:	465	Identity:	163/465 - (35%)
Similarity:	251/465 - (53%)	Gaps:	38/465 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ESWLKISCLLCIFGFLRELRPSEPYHAEILMGEWYHVTQDEVNRSVYPVGTYSYLALLIFVFLIT 66
            |.|...:.|||.:||...||||||:....|:|...::|:.:|...:|||.|||||.||..|||.|
Mouse    28 ECWFLPTALLCAYGFFANLRPSEPFLTPYLLGPDKNLTERQVYNEIYPVWTYSYLLLLFPVFLAT 92

  Fly    67 DLLRYKPVIIANATTGICIWGTLIWTTTLSGLQAVEVFYGFYQAGEVAYYSYIYAKVDKQYYPRV 131
            |.|||||||:....:.|..|..|::...|..:|.:|.|||...|.|:|||||||..||...|.:|
Mouse    93 DYLRYKPVILLQGLSLIVTWFMLLYAQGLLAIQFLEFFYGIATATEIAYYSYIYTVVDLGMYQKV 157

  Fly   132 TSHTRAAMFVGKLVAGILAQMVIGMRWMNYKQLFYITVTSQVAALLWAFFLPKVEKSLYFHNRSE 196
            ||:.|:|..||..|..:|.|:::.:...:...|..|::|....|...|:|||..:|||:||:...
Mouse   158 TSYCRSATLVGFTVGSVLGQILVSVVGWSLFSLNVISLTCVSVAFAVAWFLPMPQKSLFFHHIPS 222

  Fly   197 AIEG--GTKSDGGNLEKGS--------------------EQPSNEEASQEK--KIPALQLLWSHF 237
            :..|  |.|...|.:...:                    ::|..||..:.|  ::...::||:.|
Mouse   223 SCHGVNGLKVQNGGIVTDTPAANHLPGWEDIESKIPLNLDEPPVEEPEEPKPDRLRVFRVLWNDF 287

  Fly   238 RSAYTNPLVIQWSLWYAISLAGFLQITTYMQVVW-KSFENEPTIAWNGAVDVALTLL--SAVFAL 299
            ...|::..::.||:|:|:|..|:.|:..|.|.:| |...::....:||.|:...|||  |||||:
Mouse   288 LMCYSSRPLLCWSVWWALSTCGYFQVVNYAQGLWEKVMPSQNADIYNGGVEAVSTLLGASAVFAV 352

  Fly   300 LAGYFHAGRLNTRS-SLLSMALLSVLEGGCVLLSCWTDDIYLSYLGYVLYGGLFAFTITVASSEL 363
              ||.   :|:..: ..:::.|.|:|....|.:......|::.|..||::..::...||:|:.::
Mouse   353 --GYI---KLSWSTWGEMTLFLCSLLIAAAVYVMDTVQSIWVCYASYVVFRIIYMVLITIATFQI 412

  Fly   364 ASSLEEDSFALVFGFNTFVGLLLQCILTFVVVSEKANLNLNVFQQFSVYAFYFIVIGIVYSIAVI 428
            |::|..:.:|||||.|||:.|.||.:||.:||..: .|.|.:..||.:||.||..|.:|:    :
Mouse   413 AANLSMERYALVFGVNTFIALALQTLLTLIVVDAR-GLGLCITTQFLIYASYFAAISVVF----L 472

  Fly   429 LQYIWSISKK 438
            ...|.||.||
Mouse   473 ANGIVSIIKK 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14694	NP_650028.1	Folate_carrier	2..411	CDD:280024	152/436 (35%)
Slc19a2	NP_473428.1	Folate_carrier	28..459	CDD:307744	152/436 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837233
Domainoid	1	1.000	275	1.000	Domainoid score	I1741
eggNOG	1	0.900	-	-		E1_KOG3810
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	287	1.000	Inparanoid score	I2811
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56145
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001487
OrthoInspector	1	1.000	-	-		mtm8710
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10686
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X476
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.860