DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14694 and SLC19A2

DIOPT Version :9

Sequence 1:	NP_650028.1	Gene:	CG14694 / 41307	FlyBaseID:	FBgn0037845	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	NP_008927.1	Gene:	SLC19A2 / 10560	HGNCID:	10938	Length:	497	Species:	Homo sapiens

Alignment Length:	473	Identity:	161/473 - (34%)
Similarity:	256/473 - (54%)	Gaps:	43/473 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ESWLKISCLLCIFGFLRELRPSEPYHAEILMGEWYHVTQDEVNRSVYPVGTYSYLALLIFVFLIT 66
            |.|...:.|||.:||...||||||:....|:|...::|:.||...:|||.|||||.||..|||.|
Human    28 ECWFLPTALLCAYGFFASLRPSEPFLTPYLLGPDKNLTEREVFNEIYPVWTYSYLVLLFPVFLAT 92

  Fly    67 DLLRYKPVIIANATTGICIWGTLIWTTTLSGLQAVEVFYGFYQAGEVAYYSYIYAKVDKQYYPRV 131
            |.||||||::....:.|..|..|::...|..:|.:|.|||...|.|:|||||||:.||...|.:|
Human    93 DYLRYKPVVLLQGLSLIVTWFMLLYAQGLLAIQFLEFFYGIATATEIAYYSYIYSVVDLGMYQKV 157

  Fly   132 TSHTRAAMFVGKLVAGILAQMVIGMRWMNYKQLFYITVTSQVAALLWAFFLPKVEKSLYFH---N 193
            ||:.|:|..||..|..:|.|:::.:...:...|..|::|....|...|:|||..:|||:||   :
Human   158 TSYCRSATLVGFTVGSVLGQILVSVAGWSLFSLNVISLTCVSVAFAVAWFLPMPQKSLFFHHIPS 222

  Fly   194 RSEAIEGGTKSDGG-----------------------NLEKGSEQPSNEEASQEKKIPALQLLWS 235
            ..:.:.|....:||                       |:|   |.|..|...:..::..|::||:
Human   223 TCQRVNGIKVQNGGIVTDTPASNHLPGWEDIESKIPLNME---EPPVEEPEPKPDRLLVLKVLWN 284

  Fly   236 HFRSAYTNPLVIQWSLWYAISLAGFLQITTYMQVVW-KSFENEPTIAWNGAVDVALTLLSAVFAL 299
            .|...|::..::.||:|:|:|..|:.|:..|.|.:| |...:.....:||.|:...|||.||...
Human   285 DFLMCYSSRPLLCWSVWWALSTCGYFQVVNYTQGLWEKVMPSRYAAIYNGGVEAVSTLLGAVAVF 349

  Fly   300 LAGYFHAGRLNTRS-SLLSMALLSVLEGGCVLLSCWTDDIYLSYLGYVLYGGLFAFTITVASSEL 363
            ..||.   :::..: ..::::|.|:|....|.:.....:|::.|..||::..::...||:|:.::
Human   350 AVGYI---KISWSTWGEMTLSLFSLLIAAAVYIMDTVGNIWVCYASYVVFRIIYMLLITIATFQI 411

  Fly   364 ASSLEEDSFALVFGFNTFVGLLLQCILTFVVVSEKANLNLNVFQQFSVYAFYFIVIGIVY--SIA 426
            |::|..:.:|||||.|||:.|.||.:||.:|| :.:.|.|.:..||.:||.||.:|.:|:  |.|
Human   412 AANLSMERYALVFGVNTFIALALQTLLTLIVV-DASGLGLEITTQFLIYASYFALIAVVFLASGA 475

  Fly   427 VILQYIWSISKKPKAIQE 444
            |      |:.||.:.:::
Human   476 V------SVMKKCRKLED 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14694	NP_650028.1	Folate_carrier	2..411	CDD:280024	149/436 (34%)
SLC19A2	NP_008927.1	Folate_carrier	28..458	CDD:307744	149/436 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147306
Domainoid	1	1.000	274	1.000	Domainoid score	I1777
eggNOG	1	0.900	-	-		E1_KOG3810
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	287	1.000	Inparanoid score	I2837
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56145
OrthoDB	1	1.010	-	-		D344994at33208
OrthoFinder	1	1.000	-	-		FOG0001487
OrthoInspector	1	1.000	-	-		mtm8471
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10686
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X476
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.870