Protein Alignment CG4565 and SETDB1

DIOPT Version :10

• Sequence 1: NP_001097743.1
• Gene: CG4565 / 41303
• FlyBaseID: FBgn0037841
• Length: 269
• Species: Drosophila melanogaster
• Sequence 2: NP_001353346.1
• Gene: SETDB1 / 9869
• HGNCID: 10761
• Length: 1292
• Species: Homo sapiens
• Alignment Length: 166
• Identity: 51/166 - (30%)
• Similarity: 68/166 - (40%)
• Gaps: 40/166 - (24%)

  Fly     1 MDESETAPNDDYEHPDGLDYILESVLMPSDG-----SKEFKFLADEYNSVLLNPCHCKGACENSE 60
            ::|.:|.|      |..:.|..|.:  |..|     ..||           |..|.||..|.:..
Human   695 VNEIDTTP------PPQVAYSKERI--PGKGVFINTGPEF-----------LVGCDCKDGCRDKS 740

  Fly    61 VCA-H-----------GGQYEFTEDGSELILRNSANP--VIECNDMCKCCRNTCSNRLVYSGPRK 111
            .|| |           |||.. ...|.:........|  |.|||..|||..|.|:||||..|.:.
Human   741 KCACHQLTIQATACTPGGQIN-PNSGYQYKRLEECLPTGVYECNKRCKCDPNMCTNRLVQHGLQV 804

  Fly   112 HLEIFDSPVYGSKGLRTTAKITKGGYICEYAGELLT 147
            .|::|.:...| .|:|....|.||.::|.|||::||
Human   805 RLQLFKTQNKG-WGIRCLDDIAKGSFVCIYAGKILT 839

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4565	NP_001097743.1	SET_SETMAR	16..267	CDD:380942	47/151 (31%)
SETDB1	NP_001353346.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	108..147
		DUF5604	193..250	CDD:408109
		Tudor_SETDB1_rpt1	260..341	CDD:410453
		Tudor_SETDB1_rpt2	348..401	CDD:410548
		MBD	598..673	CDD:128673
		SET_SETDB1	675..>876	CDD:380915	51/166 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	869..1161
		SET	<1203..1292	CDD:394802