Protein Alignment CG4565 and KMT2B

DIOPT Version :10

• Sequence 1: NP_001097743.1
• Gene: CG4565 / 41303
• FlyBaseID: FBgn0037841
• Length: 269
• Species: Drosophila melanogaster
• Sequence 2: NP_055542.1
• Gene: KMT2B / 9757
• HGNCID: 15840
• Length: 2715
• Species: Homo sapiens
• Alignment Length: 238
• Identity: 58/238 - (24%)
• Similarity: 100/238 - (42%)
• Gaps: 57/238 - (23%)

  Fly    35 FKFLADEYNSVLLNPCHCKGACENSEVCAHGGQYEFTEDGSELILRNSANPVIECNDMCKCCRNT 99
            |.|||.::. ||.....|                  .|:..|:.||::              |..
Human  2524 FNFLASQHR-VLPEGATC------------------DEEEDEVQLRST--------------RRA 2555

  Fly   100 CSNRLVYSGPRKHLE--------IFDSPVYGSKGLRTTAKITKGGYICEYAGELL--TVPEARSR 154
            .|..|..:...:||:        ::.|.::| :||.....|..|..:.||:|.::  .:.:.|.:
Human  2556 TSLELPMAMRFRHLKKTSKEAVGVYRSAIHG-RGLFCKRNIDAGEMVIEYSGIVIRSVLTDKREK 2619

  Fly   155 LHDNEKLGLMNYILVLNEYTSDKKQQVTIVDPSRRGNIGRYLNHSCEPNCHIAAVRIDCPIPKIG 219
            .:|.:.:|.  |:..::::        .:||.:..||..|::||||||||....:.::.. ..|.
Human  2620 FYDGKGIGC--YMFRMDDF--------DVVDATMHGNAARFINHSCEPNCFSRVIHVEGQ-KHIV 2673

  Fly   220 IFAARDIAAKEELCFHYGGEGQYKKMTGGKTCLCGASKCTGFM 262
            |||.|.|...|||.:.|  :...:..:....|.|||.:|..|:
Human  2674 IFALRRILRGEELTYDY--KFPIEDASNKLPCNCGAKRCRRFL 2714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4565	NP_001097743.1	SET_SETMAR	16..267	CDD:380942	58/238 (24%)
KMT2B	NP_055542.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..65
		Menin-binding motif (MBM). /evidence=ECO:0000269|PubMed:22327296	17..36
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	81..302
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	320..518
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	532..771
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	819..868
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	894..959
		zf-CXXC	958..1005	CDD:366873
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1027..1132
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1146..1166
		PHD1_KMT2B	1203..1249	CDD:277064
		PHD2_KMT2B	1251..1300	CDD:277066
		PHD3_KMT2B	1337..1393	CDD:277068
		Bromo_ALL-1	1374..1516	CDD:99925
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1545..1567
		ePHD_KMT2B	1581..1685	CDD:277164
		FYRN	1733..1780	CDD:461787
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1806..1978
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2008..2093
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2118..2162
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2280..2412
		FYRC	2413..2497	CDD:197781
		WDR5 interaction motif (WIN). /evidence=ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:22665483	2508..2513
		SET_KMT2A_2B	2562..2715	CDD:380947	44/167 (26%)