Protein Alignment CG4565 and SETD1A

DIOPT Version :10

• Sequence 1: NP_001097743.1
• Gene: CG4565 / 41303
• FlyBaseID: FBgn0037841
• Length: 269
• Species: Drosophila melanogaster
• Sequence 2: NP_055527.1
• Gene: SETD1A / 9739
• HGNCID: 29010
• Length: 1707
• Species: Homo sapiens
• Alignment Length: 252
• Identity: 62/252 - (24%)
• Similarity: 100/252 - (39%)
• Gaps: 48/252 - (19%)

  Fly    28 PSDGSKEF--------------KFLADEYNSVLLNPCHCKGACENSE-VCAHGGQYEFTEDGSE- 76
            |.||.:|.              |...|:|..|      |..:....| |...|.....:|..||
Human  1482 PQDGPREHQTGSARSEGYYPISKKEKDKYLDV------CPVSARQLEGVDTQGTNRVLSERRSEQ 1540

  Fly    77 -LILRNSANPVIECNDMCKCCRNTCSNRLVYSGPRKHLEIFDSPVYGSKGLRTTAKITKGGYICE 140
             .:|.......|..:|:.|.      |:|.:.  :|.|....|.:: ..||.....|.....:.|
Human  1541 RRLLSAIGTSAIMDSDLLKL------NQLKFR--KKKLRFGRSRIH-EWGLFAMEPIAADEMVIE 1596

  Fly   141 YAGELL--TVPEARSRLHDNEKLGLMNYILVLNEYTSDKKQQVTIVDPSRRGNIGRYLNHSCEPN 203
            |.|:.:  .|.:.|.:.:..|.:| .:|:.        :....||:|.::.||:.|::||.|.||
Human  1597 YVGQNIRQMVADMREKRYVQEGIG-SSYLF--------RVDHDTIIDATKCGNLARFINHCCTPN 1652

  Fly   204 CHIAAVRIDCPIPKIGIFAARDIAAKEELCFHYGGEGQYKKMTGGKTCLCGASKCTG 260
            |:...:.|:.. .||.|::.:.|...||:.:.|....:..|:    .||||...|.|
Human  1653 CYAKVITIESQ-KKIVIYSKQPIGVDEEITYDYKFPLEDNKI----PCLCGTESCRG 1704

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4565	NP_001097743.1	SET_SETMAR	16..267	CDD:380942	62/252 (25%)
SETD1A	NP_055527.1	Interaction with WDR82. /evidence=ECO:0000269|PubMed:37030068	60..89
		RRM_Set1A	92..186	CDD:409964
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	194..308
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	331..363
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	381..486
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	506..655
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	834..854
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	891..1251
		PRK12323	<1070..>1130	CDD:481241
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1264..1293
		HCFC1-binding motif (HBM)	1299..1303
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1307..1417
		Interaction with CFP1	1415..1450
		N-SET	1425..1562	CDD:463344	19/91 (21%)
		Interaction with ASH2L, RBBP5 and WDR5. /evidence=ECO:0000269|PubMed:17998332	1450..1537		13/60 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1472..1499		4/16 (25%)
		WDR5 interaction motif (WIN). /evidence=ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:22665483	1492..1497		0/4 (0%)
		RxxxRR motif. /evidence=ECO:0000250|UniProtKB:P38827	1537..1542		2/4 (50%)
		SET_SETD1	1556..1703	CDD:380946	43/169 (25%)