Protein Alignment CG4565 and ezh2

DIOPT Version :10

• Sequence 1: NP_001097743.1
• Gene: CG4565 / 41303
• FlyBaseID: FBgn0037841
• Length: 269
• Species: Drosophila melanogaster
• Sequence 2: NP_001070747.1
• Gene: ezh2 / 768133
• ZFINID: ZDB-GENE-041111-259
• Length: 760
• Species: Danio rerio
• Alignment Length: 242
• Identity: 70/242 - (28%)
• Similarity: 109/242 - (45%)
• Gaps: 51/242 - (21%)

  Fly    25 VLMPSDGSKEFKFLADEYNSVLLNPC-HCKGACENSEVCAHGGQY--EFTEDGSELILR------ 80
            :.:..|||..     ..||   ..|| |.:..|::|..|.....:  :|.:..||...|
Zfish   520 IQLKKDGSSN-----HVYN---YQPCDHPRQPCDSSCPCVTAQNFCEKFCQCSSECQNRFPGCRC 576

  Fly    81 ----NSAN-----PVIECN-DMCKCC--------RN-TCSNRLVYSGPRKHLEIFDSPVYGSKGL 126
                |:..     .|.||: |:|..|        :| :|.|..:..|.:|||.:..|.|.| .|:
Zfish   577 KAQCNTKQCPCYLAVRECDPDLCLTCGAAEHWDSKNVSCKNCSIQRGAKKHLLLAPSDVAG-WGI 640

  Fly   127 RTTAKITKGGYICEYAGELLTVPEA--RSRLHDNEKLGLMNYILVLNEYTSDKKQQVTIVDPSRR 189
            .....:.|..:|.||.||:::..||  |.:::|..   :.:::..||   :|     .:||.:|:
Zfish   641 FIKEPVQKNEFISEYCGEIISQDEADRRGKVYDKY---MCSFLFNLN---ND-----FVVDATRK 694

  Fly   190 GNIGRYLNHSCEPNCHIAAVRIDCPIPKIGIFAARDIAAKEELCFHY 236
            ||..|:.|||..|||:...:.::.. .:|||||.|.|...|||.|.|
Zfish   695 GNKIRFANHSVNPNCYAKVMMVNGD-HRIGIFAKRAIQTGEELFFDY 740

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4565	NP_001097743.1	SET_SETMAR	16..267	CDD:380942	70/242 (29%)
ezh2	NP_001070747.1	EZH2_WD-Binding	39..68	CDD:463308
		PRC2_HTH_1	159..262	CDD:436286
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	208..231
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	356..444
		preSET_CXC	573..604	CDD:408079	7/30 (23%)
		SET_EZH2	623..742	CDD:380995	45/131 (34%)