Protein Alignment CG4565 and NSD1

DIOPT Version :10

• Sequence 1: NP_001097743.1
• Gene: CG4565 / 41303
• FlyBaseID: FBgn0037841
• Length: 269
• Species: Drosophila melanogaster
• Sequence 2: NP_071900.2
• Gene: NSD1 / 64324
• HGNCID: 14234
• Length: 2696
• Species: Homo sapiens
• Alignment Length: 253
• Identity: 74/253 - (29%)
• Similarity: 110/253 - (43%)
• Gaps: 76/253 - (30%)

  Fly    13 EHPDGLDYILESVLMPSDGSKEFKFLADEYNSVLLNPCHCKGACENSEVCAHGGQYEFTEDGSEL 77
            |:|.|:|                   ::..|.:||..||       ..||..||:
Human  1902 ENPCGID-------------------SECINRMLLYECH-------PTVCPAGGR---------- 1930

  Fly    78 ILRNSANPVIECNDMCKCCRNTCSNRLVYSGPRKHLEIFDSPVYGSKGLRTTAKITKGGYICEYA 142
                              |:|.|.::..|    ..:|||.:...| .||||...|.||.::.||.
Human  1931 ------------------CQNQCFSKRQY----PEVEIFRTLQRG-WGLRTKTDIKKGEFVNEYV 1972

  Fly   143 GELLTVPEARSRLHDNEKLGLMNYILVLNEYTSDKKQQVTIVDPSRRGNIGRYLNHSCEPNCHIA 207
            |||:...|.|:|:...::..:.|:.::    |.||.:   |:|...:||..|::||.|:|||...
Human  1973 GELIDEEECRARIRYAQEHDITNFYML----TLDKDR---IIDAGPKGNYARFMNHCCQPNCETQ 2030

  Fly   208 --AVRIDCPIPKIGIFAARDIAAKEELCFHYGGEGQYKKMTGGKT-CLCGASKCTGFM 262
              :|..|   .::|:||..||.|..||.|:|..|    .:..||| |.|||..|:||:
Human  2031 KWSVNGD---TRVGLFALSDIKAGTELTFNYNLE----CLGNGKTVCKCGAPNCSGFL 2081

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4565	NP_001097743.1	SET_SETMAR	16..267	CDD:380942	72/250 (29%)
NSD1	NP_071900.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	207..252
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	281..311
		PWWP_NSD1_rpt1	318..433	CDD:438989
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	487..514
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	872..891
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	936..1035
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1067..1093
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1112..1134
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1243..1272
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1294..1344
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1382..1428
		TNG2	<1431..1587	CDD:227367
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1480..1534
		PHD1_NSD1_2	1545..1587	CDD:277118
		PHD2_NSD1	1592..1638	CDD:277120
		PHD3_NSD1	1639..1692	CDD:277123
		PHD4_NSD1	1709..1748	CDD:277126
		PWWP_NSD1_rpt2	1755..1850	CDD:438992
		AWS	1901..1939	CDD:465559	16/90 (18%)
		SET_NSD1	1941..2082	CDD:380987	58/160 (36%)
		Inhibits enzyme activity in the absence of bound histone	2060..2066		1/9 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2091..2111
		PHD5_NSD1	2120..2162	CDD:277129
		C5HCH	2161..2210	CDD:465605
		PHA03247	<2208..2574	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2213..2422
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2464..2499
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2553..2575
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2595..2616
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2665..2696