Protein Alignment CG4565 and KMT2C

DIOPT Version :10

• Sequence 1: NP_001097743.1
• Gene: CG4565 / 41303
• FlyBaseID: FBgn0037841
• Length: 269
• Species: Drosophila melanogaster
• Sequence 2: NP_733751.2
• Gene: KMT2C / 58508
• HGNCID: 13726
• Length: 4911
• Species: Homo sapiens
• Alignment Length: 317
• Identity: 74/317 - (23%)
• Similarity: 114/317 - (35%)
• Gaps: 105/317 - (33%)

  Fly    15 PDGL-DYILESVLMPSDGSKEFKFLADEYNSVLLNPCHCKG----------------------AC 56
            |.|: |.|||.|......|:..:          |.|.:.||                      ||
Human  4630 PKGVWDKILEPVACVRKKSEMLQ----------LFPAYLKGEDLFGLTVSAVARIAESLPGVEAC 4684

  Fly    57 ENSEVCAHGGQYEFTEDGSELI-LRNSANP----------------------VIECNDMCKCCRN 98
            ||         |.|....:.|: |..:.||                      .:......|..::
Human  4685 EN---------YTFRYGRNPLMELPLAVNPTGCARSEPKMSAHVKRFVLRPHTLNSTSTSKSFQS 4740

  Fly    99 TC--------SNRLVYSGP---RKHLEIFDSPVYGSK------GLRTTAKITKGGYICEYAGELL 146
            |.        |.:.|:|..   ||....:.|.||.::      ||.....|.|...:.||.|.::
Human  4741 TVTGELNAPYSKQFVHSKSSQYRKMKTEWKSNVYLARSRIQGLGLYAARDIEKHTMVIEYIGTII 4805

  Fly   147 --TVPEARSRLHDNEKLGLMNYILVL-NEYTSDKKQQVTIVDPSRRGNIGRYLNHSCEPNCHIAA 208
              .|...:.:|::::..|:  |:..: |::         ::|.:..|...||:||||.|||....
Human  4806 RNEVANRKEKLYESQNRGV--YMFRMDNDH---------VIDATLTGGPARYINHSCAPNCVAEV 4859

  Fly   209 VRIDCPIPKIGIFAARDIAAKEELCFHYG---GEGQYKKMTGGKTCLCGASKCTGFM 262
            |..:.. .||.|.::|.|...||||:.|.   .:.|:|     ..|.|||..|..:|
Human  4860 VTFERG-HKIIISSSRRIQKGEELCYDYKFDFEDDQHK-----IPCHCGAVNCRKWM 4910

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4565	NP_001097743.1	SET_SETMAR	16..267	CDD:380942	73/316 (23%)
KMT2C	NP_733751.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..101
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	164..203
		ePHD1_KMT2C	247..330	CDD:277166
		PHD1_KMT2C_like	343..388	CDD:276984
		PHD2_KMT2C	390..435	CDD:277069
		PHD3_KMT2C	466..517	CDD:276986
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	721..742
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	763..798
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	828..864
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	885..912
		PHD4_KMT2C	952..1008	CDD:277071
		PHD5_KMT2C_like	1009..1055	CDD:276988
		RanBP2-type Zn finger	1084..1106	CDD:275375
		PHD6_KMT2C	1086..1136	CDD:277073
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1215..1324
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1406..1431
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1458..1485
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1604..1630
		HMG-box_KMT2C	1633..1713	CDD:438835
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1709..2448
		PHA03247	<1876..2353	CDD:223021
		Atrophin-1	2219..>2547	CDD:460830
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2589..2694
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2793..2887
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2925..2954
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2989..3029
		TPH	<3176..>3272	CDD:464007
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3205..3241
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3353..3409
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3527..3583
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3596..3919
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	4024..4053
		ePHD2_KMT2C	4402..4506	CDD:277167
		FYRN	4551..4602	CDD:461787
		FYRC	4610..4697	CDD:197781	18/85 (21%)
		WDR5 interaction motif (WIN). /evidence=ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:22665483	4707..4712		0/4 (0%)
		SET_KMT2C_2D	4758..4910	CDD:380948	46/168 (27%)