Protein Alignment CG4565 and ASH1L

DIOPT Version :10

• Sequence 1: NP_001097743.1
• Gene: CG4565 / 41303
• FlyBaseID: FBgn0037841
• Length: 269
• Species: Drosophila melanogaster
• Sequence 2: NP_001353106.1
• Gene: ASH1L / 55870
• HGNCID: 19088
• Length: 2969
• Species: Homo sapiens
• Alignment Length: 222
• Identity: 59/222 - (26%)
• Similarity: 102/222 - (45%)
• Gaps: 42/222 - (18%)

  Fly    50 CHCKGACENSEVCAHGGQYEFTEDGSELILRNSANPVI--ECN-DMCKCCRNTCSNRLVYSGPRK 111
            |:||               :..:|..:..:.:..|.:|  ||: :.|.|....|:.|:     ::
Human  2096 CNCK---------------KPDDDTRKGCVDDCLNRMIFAECSPNTCPCGEQCCNQRI-----QR 2140

  Fly   112 H-----LEIFDSPVYGSKGLRTTAKITKGGYICEYAGELLTVPEARSRLHDNEKLGLMNYILVLN 171
            |     ||.|.:...| .|:||...:..|.:|.||.||:::..|.|:|:.:.......:|.|.|:
Human  2141 HEWVQCLERFRAEEKG-WGIRTKEPLKAGQFIIEYLGEVVSEQEFRNRMIEQYHNHSDHYCLNLD 2204

  Fly   172 EYTSDKKQQVTIVDPSRRGNIGRYLNHSCEPNCHIAAVRIDCPIPKIGIFAARDIAAKEELCFHY 236
                    ...::|..|.||..|::||||:|||.:....:: .:.:||::|.:|:.|..||.:.|
Human  2205 --------SGMVIDSYRMGNEARFINHSCDPNCEMQKWSVN-GVYRIGLYALKDMPAGTELTYDY 2260

  Fly   237 GGEG-QYKKMTGGKTCLCGASKCTGFM 262
            .... ..:|.   :.|.||..||.|.:
Human  2261 NFHSFNVEKQ---QLCKCGFEKCRGII 2284

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4565	NP_001097743.1	SET_SETMAR	16..267	CDD:380942	59/222 (27%)
ASH1L	NP_001353106.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..70
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	118..143
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	501..525
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	537..583
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	824..845
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	878..966
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1100..1128
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1151..1231
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1243..1281
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1489..1508
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1580..1711
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1741..1761
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1911..1991
		Catalytic domain	2069..2288		59/222 (27%)
		AWS	2092..2143	CDD:197795	13/66 (20%)
		SET_ASH1L	2146..2286	CDD:380951	46/152 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2288..2346
		Bromo_ASH1	2443..2548	CDD:99955
		PHD_ASH1L	2586..2628	CDD:277023
		BAH_polybromo	2665..2799	CDD:240068
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2825..2856
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2876..2919