Protein Alignment CG4565 and SETD2

DIOPT Version :10

• Sequence 1: NP_001097743.1
• Gene: CG4565 / 41303
• FlyBaseID: FBgn0037841
• Length: 269
• Species: Drosophila melanogaster
• Sequence 2: NP_054878.5
• Gene: SETD2 / 29072
• HGNCID: 18420
• Length: 2564
• Species: Homo sapiens
• Alignment Length: 266
• Identity: 64/266 - (24%)
• Similarity: 112/266 - (42%)
• Gaps: 41/266 - (15%)

  Fly    10 DDYEHPDGLDYILESVLMPS--DGSKEFKFLAD-----EYNSVLLNPCHCKGACENSEVCAHGGQ 67
            ||:..|.......:...||.  |..:|..:|.:     .:..:....|.|....::...   .|:
Human  1452 DDFRDPQRWKECAKQGKMPCYFDLIEENVYLTERKKNKSHRDIKRMQCECTPLSKDERA---QGE 1513

  Fly    68 YEFTEDGSELILRNSANPVIECNDMCKCCRNTCSNRLVYSGPRKHLEIFDSPVYGSKGLRTTAKI 132
            ....||....:|      :|||:..|. ..:.||||.........:|:..:...| .|||....:
Human  1514 IACGEDCLNRLL------MIECSSRCP-NGDYCSNRRFQRKQHADVEVILTEKKG-WGLRAAKDL 1570

  Fly   133 TKGGYICEYAGELLTVPEARSRLHDNEK-LGLMNYILVLNEYTSDKKQQVTIVDPSRRGNIGRYL 196
            ....::.||.||:|...|.::|:.:..: ..:..|.:.|.   :|:     |:|.:::||..|::
Human  1571 PSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYFMALK---NDE-----IIDATQKGNCSRFM 1627

  Fly   197 NHSCEPNCHIAAVRIDCPIPKIGIFAARDIAAKEELCF-----HYGGEGQYKKMTGGKTCLCGAS 256
            ||||||||......::..: ::|.|..:.:.:..||.|     .||.|.|        .|.||::
Human  1628 NHSCEPNCETQKWTVNGQL-RVGFFTTKLVPSGSELTFDYQFQRYGKEAQ--------KCFCGSA 1683

  Fly   257 KCTGFM 262
            .|.|::
Human  1684 NCRGYL 1689

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4565	NP_001097743.1	SET_SETMAR	16..267	CDD:380942	61/260 (23%)
SETD2	NP_054878.5	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	180..211
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	272..561
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	607..626
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	964..995
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1036..1101
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1133..1233
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1264..1352
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1393..1443
		Interaction with TUBA1A. /evidence=ECO:0000269|PubMed:27518565	1418..1714		64/266 (24%)
		AWS	1495..1549	CDD:197795	14/63 (22%)
		SET_SETD2	1549..1690	CDD:380949	42/159 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1831..1872
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1921..2142
		Low charge region. /evidence=ECO:0000269|PubMed:16118227	2137..2366
		WW	2391..2420	CDD:459800
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2439..2465
		Interaction with POLR2A. /evidence=ECO:0000269|PubMed:16314571	2457..2564
		SRI	2467..2555	CDD:462404