Protein Alignment CG4565 and EZH1

DIOPT Version :10

• Sequence 1: NP_001097743.1
• Gene: CG4565 / 41303
• FlyBaseID: FBgn0037841
• Length: 269
• Species: Drosophila melanogaster
• Sequence 2: NP_001308008.1
• Gene: EZH1 / 2145
• HGNCID: 3526
• Length: 753
• Species: Homo sapiens
• Alignment Length: 199
• Identity: 63/199 - (31%)
• Similarity: 92/199 - (46%)
• Gaps: 44/199 - (22%)

  Fly    50 CHCKGACENSEVCAHGGQYEFTEDGSELILRNSANPVIECN-DMCKCCRN---------TCSNRL 104
            |.||..| |::.|.           ..|.:|       ||: |:|..|..         :|.|..
Human   567 CRCKTQC-NTKQCP-----------CYLAVR-------ECDPDLCLTCGASEHWDCKVVSCKNCS 612

  Fly   105 VYSGPRKHLEIFDSPVYGSKGLRTTAKITKGGYICEYAGELLTVPEA--RSRLHDNEKLGLMNYI 167
            :..|.:|||.:..|.|.| .|......:.|..:|.||.|||::..||  |.:::|..   :.:::
Human   613 IQRGLKKHLLLAPSDVAG-WGTFIKESVQKNEFISEYCGELISQDEADRRGKVYDKY---MSSFL 673

  Fly   168 LVLNEYTSDKKQQVTIVDPSRRGNIGRYLNHSCEPNCHIAAVRIDCPIPKIGIFAARDIAAKEEL 232
            ..||   :|     .:||.:|:||..|:.|||..|||:...|.::.. .:|||||.|.|.|.|||
Human   674 FNLN---ND-----FVVDATRKGNKIRFANHSVNPNCYAKVVMVNGD-HRIGIFAKRAIQAGEEL 729

  Fly   233 CFHY 236
            .|.|
Human   730 FFDY 733

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4565	NP_001097743.1	SET_SETMAR	16..267	CDD:380942	63/199 (32%)
EZH1	NP_001308008.1	EZH2_WD-Binding	45..74	CDD:463308
		PRC2_HTH_1	165..268	CDD:436286
		SANT	439..480	CDD:238096
		preSET_CXC	566..597	CDD:408079	13/48 (27%)
		SET_EZH1	614..749	CDD:380994	48/133 (36%)