Protein Alignment CG4565 and Kmt2a

DIOPT Version :10

• Sequence 1: NP_001097743.1
• Gene: CG4565 / 41303
• FlyBaseID: FBgn0037841
• Length: 269
• Species: Drosophila melanogaster
• Sequence 2: NP_001344478.1
• Gene: Kmt2a / 214162
• MGIID: 96995
• Length: 3966
• Species: Mus musculus
• Alignment Length: 286
• Identity: 75/286 - (26%)
• Similarity: 116/286 - (40%)
• Gaps: 81/286 - (28%)

  Fly    16 DGLDYILESVLMPSDGSK-----EFKF-LADEYNSVLLNPCHCKGACENSEVCAHGGQYEFTEDG 74
            |.:.:::|.:.    |:|     :|:| ..:|.|...|||              ||..      .
Mouse  3722 DAVVFLIEQLA----GAKHCRNYKFRFHKPEEANEPPLNP--------------HGSA------R 3762

  Fly    75 SELILRNSA-----------------NPVIECND------MCKCCRNTCSNRLVYSGPRKHLE-- 114
            :|:.||.||                 ||    ||      ..|..|...|..|......:||:
Mouse  3763 AEVHLRKSAFDMFNFLASKHRQPPEYNP----NDEEEEEVQLKSARRATSMDLPMPMRFRHLKKT 3823

  Fly   115 ------IFDSPVYGSKGLRTTAKITKGGYICEYAGELL--TVPEARSRLHDNEKLGLMNYILVLN 171
                  ::.||::| :||.....|..|..:.||||.::  ...:.|.:.:|::.:|...:.:..:
Mouse  3824 SKEAVGVYRSPIHG-RGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDS 3887

  Fly   172 EYTSDKKQQVTIVDPSRRGNIGRYLNHSCEPNCHIAAVRIDCPIPKIGIFAARDIAAKEELCFHY 236
            |          :||.:..||..|::||||||||:...:.||.. ..|.|||.|.|...|||.:.|
Mouse  3888 E----------VVDATMHGNAARFINHSCEPNCYSRVINIDGQ-KHIVIFAMRKIYRGEELTYDY 3941

  Fly   237 GGEGQYKKMTGGKTCLCGASKCTGFM 262
              :...:..:....|.|||.||..|:
Mouse  3942 --KFPIEDASNKLPCNCGAKKCRKFL 3965

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4565	NP_001097743.1	SET_SETMAR	16..267	CDD:380942	75/286 (26%)
Kmt2a	NP_001344478.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..106
		Menin-binding motif (MBM). /evidence=ECO:0000250|UniProtKB:Q03164	6..25
		Integrase domain-binding motif 1 (IBM1). /evidence=ECO:0000250|UniProtKB:Q03164	121..132
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	130..231
		Integrase domain-binding motif 2 (IBM2). /evidence=ECO:0000250|UniProtKB:Q03164	145..150
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	322..343
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	440..590
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	711..943
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	963..1003
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1034..1064
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1101..1161
		zf-CXXC	1144..1191	CDD:366873
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1196..1390
		PHD1_KMT2A	1432..1478	CDD:277063
		PHD2_KMT2A	1480..1529	CDD:277065
		PHD3_KMT2A	1567..1626	CDD:277067
		Interaction with histone H3K4me3. /evidence=ECO:0000250|UniProtKB:Q03164	1583..1599
		Bromo_ALL-1	1649..1779	CDD:99925
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1665..1714
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1807..1870
		ePHD_KMT2A	1873..1985	CDD:277163
		FYRN	2026..2073	CDD:461787
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2147..2174
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2214..2339
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2371..2619
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2639..2673
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2709..2759
		9aaTAD. /evidence=ECO:0000250|UniProtKB:Q03164	2843..2851
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2958..3060
		Herpes_BLLF1	<3152..>3361	CDD:282904
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3164..3239
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3462..3640
		FYRC	3666..3749	CDD:197781	6/30 (20%)
		WDR5 interaction motif (WIN). /evidence=ECO:0000250|UniProtKB:Q03164	3759..3764		1/10 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3782..3805		5/26 (19%)
		SET_KMT2A_2B	3813..3966	CDD:380947	49/167 (29%)