DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad86C and Pcdhb15

DIOPT Version :9

Sequence 1:	NP_001247033.1	Gene:	Cad86C / 41302	FlyBaseID:	FBgn0261053	Length:	1949	Species:	Drosophila melanogaster
Sequence 2:	NP_444370.1	Gene:	Pcdhb15 / 93886	MGIID:	2136750	Length:	786	Species:	Mus musculus

Alignment Length:	712	Identity:	156/712 - (21%)
Similarity:	250/712 - (35%)	Gaps:	209/712 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   294 SPLFAIRQKI--VSSETTEGTVFLL---------------------------------GP----- 318
            ||:|..::.:  :|..||.|...||                                 ||
Mouse   130 SPVFLDKEILLKISESTTPGATLLLERAQDADVGTNSLSNYTISPNDYFHIHVHDGGEGPIIPEL 194

  Fly   319 -----LDFEKQAMYHLTILANDAYAEPGQDSRNIAGMEIV-VIVQDVQDQPPVFTSAPPVTKLPP 377
                 ||.|:...:.||:.|.|..:.|.      :|..:| ::|.|:.|..|.|..:....:.|.
Mouse   195 VLDKMLDREEIPEFTLTLTALDGGSPPR------SGTALVQILVLDINDNSPQFVQSLYKVQSPE 253

  Fly   378 GILPGDKILQVHAEDGDKGNPREVRYGLVSENNPFTSFFDINETSGEIFLMRPLEDIAFITHVGD 442
            ....|..::.|.|.|.|.|:..::.|............|.||.||||::|.|.|...|..|:
Mouse   254 NTPVGSLVVAVSARDLDTGSYGQIDYTFFYATERILQTFQINSTSGELYLKRELNYEAIQTY--- 315

  Fly   443 PVLLTV-------------IAEEVKVGRDEPPALASTVQLAFFLPDRTNSPPYFENDHYVSRVDE 494
              .:|:             :..||....|.||.         ||....|||           :.|
Mouse   316 --SITIQARDGGGLSGKCAVVVEVMDVNDNPPE---------FLLSSLNSP-----------IPE 358

  Fly   495 NAPHGTALTFVDPYVPRVYDDDTGKNGVFSLTLLNNNGTFEISPNVAERSAGFLIRVRDNSMLDY 559
            |:.......|      ::.|.|:|.||. :|..:.|:..|.:.|:|    ..|...|.:.. ||.
Mouse   359 NSQETVVAVF------KIRDRDSGNNGK-TLCSIANDLPFVLKPSV----ENFYTLVTEKP-LDR 411

  Fly   560 EQQQSVQFQILAQELGPATNLSALVNVTVYINDVNDNAPVFEQPAYSVELPENMTAGTKVVQVLA 624
            |........|...::| ...|:....:||.::|:|||||.|.|.:|::.:.||.:....:..:.|
Mouse   412 ESNTEYNITITVTDMG-IPRLTTQHTITVQVSDINDNAPTFTQTSYTMFVRENNSPALHIGTISA 475

  Fly   625 TDPDSGLGGKVRYTAILGY-----LNTSLNLDAETGLITVSTNKHGFDREVMPEYHLYVEARDMD 684
            ||.|||....:.|:..|.:     |::.::::|:.|.:..   ....|.|.:..:..:|.|.|..
Mouse   476 TDSDSGSNAHITYSLRLPHDPQLALDSLISINADNGQLFA---LRALDYEALQAFEFHVGAIDQG 537

  Fly   685 GEGNRAQVPLIIKLIDVNDETPIFDKDLY----------EFILTHDLMGFTTTAVIHAEDKDATA 739
            .....:|..:.:.::|.||..|..   ||          |.:......|:..|.|: |.|:| :.
Mouse   538 SPALSSQALVRVVILDDNDNAPFV---LYPMQNASAPYTELLPRAAEPGYLVTKVV-AVDRD-SG 597

  Fly   740 PNNEVRYEIINGNYDNQFVLDKVTGELTV----------REKIHLRSKKNAKTRR---------- 784
            .|..:.::::.......|.:....||:..          :.|:.:..|.|.:..|
Mouse   598 QNAWLSFQLLKATEPGLFSVWAHNGEVRTTRLLSERDVPKHKLLVVVKDNGEPPRSASVTLHVLL 662

  Fly   785 ---------------RRQAGSDDEDT-----------DIFILT------------ARAYDLGVPV 811
                           |..|..|||.|           .:|:::            |||...||
Mouse   663 VDGFSQPFLILPEVARDPAQEDDELTLYLVIALASVSSLFLVSVLLFVGVRLCRRARAASPGV-- 725

  Fly   812 RFSTTTIRVYPPESRKRSVKFVVPGHNPDKAKTEETLS-------ALSGGKVYIHNIRPLSP 866
                    .:.||..       .|||..| .....|||       .|:||.......:.|||
Mouse   726 --------CFVPEEH-------FPGHLVD-VSGAGTLSQNYQYEVCLTGGSGITSEFKFLSP 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad86C	NP_001247033.1	Cadherin_repeat	260..361	CDD:206637	23/112 (21%)
		Cadherin_repeat	372..469	CDD:206637	26/109 (24%)
		Cadherin_repeat	487..596	CDD:206637	25/108 (23%)
		Cadherin_repeat	605..703	CDD:206637	21/102 (21%)
		Cadherin_repeat	728..820	CDD:206637	24/149 (16%)
Pcdhb15	NP_444370.1	Cadherin_2	30..111	CDD:285466
		Cadherin_repeat	140..238	CDD:206637	20/103 (19%)
		Cadherin_repeat	247..343	CDD:206637	23/100 (23%)
		Cadherin_repeat	356..447	CDD:206637	25/103 (24%)
		Cadherin_repeat	455..557	CDD:206637	22/104 (21%)
		Cadherin_repeat	571..664	CDD:206637	15/94 (16%)
		Cadherin_C_2	686..769	CDD:293101	20/100 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X20
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000