DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad86C and Pcdhga6

DIOPT Version :9

Sequence 1:	NP_001247033.1	Gene:	Cad86C / 41302	FlyBaseID:	FBgn0261053	Length:	1949	Species:	Drosophila melanogaster
Sequence 2:	NP_291067.1	Gene:	Pcdhga6 / 93714	MGIID:	1935218	Length:	932	Species:	Mus musculus

Alignment Length:	658	Identity:	164/658 - (24%)
Similarity:	264/658 - (40%)	Gaps:	109/658 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 RRLEPGRYYDFQVSVKDTKGGMTT-------QLCSITATNFTTPHDLI------FPHKPGIIMIP 263
            |.:..||...|  |:....|.:.|       :||:.:|....:.:.||      :|.:..|:.|.
Mouse    65 RIISRGRSQLF--SLNQRSGSLVTAGRIDREELCAQSAPCLVSFNILIEDKLNLYPVEVEIVDIN 127

  Fly   264 EDAKR--GTELDYVI----ARKNPLFQKPVY-----------LELWGSPLFAIRQKIVSSETTEG 311
            ::|.|  ..|::..|    |..:......||           .:|.||..|::..:.........
Mouse   128 DNAPRFLKEEMELKILENAALSSHFLLMGVYDPDVGVNSIQGFKLSGSSHFSVHVQSQDHGPKYP 192

  Fly   312 TVFLLGPLDFEKQAMYHLTILANDAYAEPGQDSRNIAGMEIVVIVQDVQDQPPVFTSAPPVTKLP 376
            .:.|...||.|::|::||.::|.|     |.|........|:|.|.||.|..||||.......:|
Mouse   193 ELVLEHSLDREEEAVHHLVLVAMD-----GGDPVRTGMARILVTVVDVNDNAPVFTQPIYRVSVP 252

  Fly   377 PGILPGDKILQVHAEDGDKGNPREVRYGLVSENNPFTSFFDINETSGEIFLMRPL--EDIAFITH 439
            ..:..|.::|.|:|.|.|:|...|:.|..|......:..|.:|..:|||.....|  ||..|.
Mouse   253 ENLPVGTRVLTVNATDQDEGIHAEITYSFVRITEEISQIFCLNPLTGEISTSETLDYEDSRFY-- 315

  Fly   440 VGDPVLLTVIAEEVKVGRDEPPALASTVQLAFFLPDRTNSPPYFENDHYVSRVDENAPHGTALTF 504
                        |:.|...:...|....::...:.|..::.|..........:.||:|.||.:..
Mouse   316 ------------ELDVEARDQSDLQDRAKVLITILDMNDNAPEVVVTSGSRAIAENSPSGTVIAL 368

  Fly   505 VDPYVPRVYDDDTGKNGVFSLTLLNNNGTFEISPNVAERSAGFLIRVRDNSMLDYEQQQSVQFQI 569
            .     :|||.|:.:||:...::      .|..|...|.|.....|:..|:.||.||..|....:
Mouse   369 F-----QVYDKDSERNGLVICSI------SESLPFKLEESLDNYFRLVTNTELDREQVSSYNITV 422

  Fly   570 LAQELGPATNLSALVNVTVYINDVNDNAPVFEQPAYSVELPENMTAGTKVVQVLATDPDSGLGGK 634
            .|.:.| ...||..:.:::.:.|:|||.|||.:.:|||.:.||...|..:..:.|.||||....:
Mouse   423 TATDRG-TPPLSTKIFISLDVADINDNPPVFSRSSYSVYVSENNPKGVSIFSLNAVDPDSEENAE 486

  Fly   635 VRYT----AILGY-LNTSLNLDAETGLITVSTNKHGFDREVMPEYHLYVEARDMDGEGNRAQVPL 694
            :.|:    .:.|. |::.|::::.||::....:   ||.|...|.:|.|.|.|.......:.|.|
Mouse   487 IIYSLAKETLQGTPLSSFLSINSITGVLYALCS---FDYEQFRELNLLVTASDRGKPPLSSNVSL 548

  Fly   695 IIKLIDVNDETPIFDKDLYEFILTHDLM-----------GFTTTAVIHAEDKDATAPNNEVRYEI 748
            .:.::|.||..|   :.||..:.|....           |:..|.|: |.||| :..|..:.|.:
Mouse   549 NLFVLDQNDNVP---EILYPVLPTDGSTGVELAPRSAEPGYLVTKVV-AVDKD-SGQNAWLSYRL 608

  Fly   749 INGNYDNQFVLDKVTGEL-TVREKIHLRSKKNAKTRRRRQAGSDDEDTDIFILTARAYDLGVPVR 812
            |..:....|.:...|||: |.|..:                   |.|.....|.....|.|.|..
Mouse   609 IKASEPGLFSVGLHTGEIRTARVLL-------------------DRDALKQSLVVAVQDHGQPPL 654

  Fly   813 FSTTTIRV 820
            .:|.|:.|
Mouse   655 SATVTLTV 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad86C	NP_001247033.1	Cadherin_repeat	260..361	CDD:206637	28/117 (24%)
		Cadherin_repeat	372..469	CDD:206637	23/98 (23%)
		Cadherin_repeat	487..596	CDD:206637	28/108 (26%)
		Cadherin_repeat	605..703	CDD:206637	28/102 (27%)
		Cadherin_repeat	728..820	CDD:206637	22/92 (24%)
Pcdhga6	NP_291067.1	Cadherin_2	30..112	CDD:285466	12/48 (25%)
		Cadherin_repeat	137..238	CDD:206637	25/105 (24%)
		Cadherin_repeat	246..343	CDD:206637	24/110 (22%)
		Cadherin_repeat	356..448	CDD:206637	28/103 (27%)
		Cadherin_repeat	463..558	CDD:206637	26/97 (27%)
		Cadherin_repeat	579..664	CDD:206637	25/105 (24%)
		Cadherin_C_2	688..772	CDD:293101
		Cadherin_tail	809..>905	CDD:292596
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X20
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000