DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad86C and Cdhr1

DIOPT Version :9

Sequence 1:	NP_001247033.1	Gene:	Cad86C / 41302	FlyBaseID:	FBgn0261053	Length:	1949	Species:	Drosophila melanogaster
Sequence 2:	NP_446024.1	Gene:	Cdhr1 / 93662	RGDID:	620420	Length:	859	Species:	Rattus norvegicus

Alignment Length:	754	Identity:	222/754 - (29%)
Similarity:	332/754 - (44%)	Gaps:	92/754 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 ISLLIGILCPHHVQG--ADPKFD-----PTTRMRLVLVPADAQVNSVIYRLRATDEEFDYPLTFE 180
            ::|::|:||.:..|.  |...||     ....|.|..:|.|..|.|.:|.|..||.|.| |:::.
  Rat     7 VALVLGLLCIYLAQANFAPHFFDNGVGSTNGNMALFSLPEDTPVGSHVYTLNGTDPEGD-PISYH 70

  Fly   181 FVGDASASTVKVESLPCTKYNSVCQ--ANIVLQRRLEPGRYYDFQ--VSVKDTKGGMTTQ-LCSI 240
            ...|.|..:|          .||..  .||.|...|:..|..:.:  :|:.|....:..: :..:
  Rat    71 ISFDPSTRSV----------FSVDPNFGNITLVEELDREREDEIEAIISISDGLNLVAEKVVIVV 125

  Fly   241 TATNFTTPHDLIFPHKPGIIMIPEDAKRGTELDYVIARKNPLFQKPVYLELWGSPLFAIRQKIVS 305
            |..|...|.   |..:|..|::||:...|:.:..|.|.......        |..:....|.:.|
  Rat   126 TDANDEAPR---FLQEPYNILVPENTPAGSSIFKVQAEDKDTGS--------GGSVTYFLQSLHS 179

  Fly   306 SETT----EGTVFLL--GPLDFEKQAMYHLTILANDAYAE-PGQDSRNIAGMEIVVIVQDVQDQP 363
            |:.|    .|.:.|.  ..||:||...:.:|::|.|.... .|.|....|...:.:.|:||||..
  Rat   180 SKFTVDRHSGVLRLQAGATLDYEKSRAHFITVVAKDGGGRLRGADVVFSATTTVTINVEDVQDTA 244

  Fly   364 PVFTSAPPVTKLPPGILPGDKILQVHAEDGDKGNPREVRYGLVSENNPFTSFFDINETSGEIFLM 428
            |:|...|....:....|||.::|.|.|.|||:|.|..:.|.|::|::   ..|:||||||.|.::
  Rat   245 PIFVGTPYYGYVYEDTLPGSEVLTVVAIDGDRGKPNHILYRLLNESD---GLFEINETSGAISVL 306

  Fly   429 R---PLEDIAFITHVGDPVLLTVIAEEVKVGRDEPPALASTVQLAFFLPDRTNSPPYF------E 484
            :   .|....:..||          :..:|.....||..|||.:...:.|..|.||.|      :
  Rat   307 QSPAQLRREVYELHV----------QVTEVNSSGSPAAQSTVPVIIRIVDLNNHPPTFYGESGPQ 361

  Fly   485 NDHYVSRVDENAPHGTALTFVDPYVPRVYDDDTGKNGVFSLTLLNNNGTFEISPNVAERSAGFLI 549
            |...:| :.|:.|.|..|..:.   ..|.|.|.|.|..|:|.|:...|.|.:.|......|...|
  Rat   362 NKFELS-MFEHPPQGEILRGLK---ITVNDSDQGANAKFNLRLVGPGGIFRVVPQTVLNEAQVTI 422

  Fly   550 RVRDNSMLDYEQQQSVQFQILAQELGPATNLSALVNVTVYINDVNDNAPVFEQPAYSVELPENMT 614
            .|.:::.:|:|:.:|:.|::||.|:......|:..::.:.:.|.|||.|.|....|...:|||:.
  Rat   423 IVENSAAIDFEKSKSLTFKLLAIEVNTPEKFSSTADIVIQLLDTNDNVPKFTSHYYIARIPENVP 487

  Fly   615 AGTKVVQVLATDPDSGLGGKVRYTAILGYLNTSLNLDAETGLITVSTNKHGFDREVMPEYHLYVE 679
            .|:.||.|.|.|||:|..|||:| :|.|..:....:...|||| .:......|.|....|:.||:
  Rat   488 GGSNVVAVTAVDPDTGPWGKVQY-SIYGTGSDLFLIHPSTGLI-YTQPWASLDAEGTSRYNFYVK 550

  Fly   680 ARDMDGEGNRAQVPLIIKLIDVNDETPIFDKDLYEFILTHDLMGFTTTAVIHAEDKDATAPNNEV 744
            |.||||..:.|:|  .:.|:||||..|.|.:.:.|     ..|...|...|.|.|:||..|||.|
  Rat   551 AEDMDGRYSLAEV--FVTLLDVNDHYPQFVQSVQE-----KTMVLGTPLKIEATDQDAEEPNNLV 608

  Fly   745 RYEIINGNYDNQFVLDKVTGELTVREKIHLRSKKNAKTRRRRQAGSDDEDTDIFILTARAYDLGV 809
            .|.|......|.|.:|..|||:.::..|......:..|.....:.|         |..:|.|.|.
  Rat   609 DYSITRAEPVNVFDIDAHTGEIRLKNSIRSLEALHNITPSGEYSWS---------LQVQAKDRGS 664

  Fly   810 PVRFSTTT---IRVYPPE--SRKRSVKFVV-PGHNPDKA 842
            | .||||.   |.:...|  ||.....|:: ...||.||
  Rat   665 P-SFSTTALLKIDITDTERLSRSSMAAFLIQTKDNPMKA 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad86C	NP_001247033.1	Cadherin_repeat	260..361	CDD:206637	26/107 (24%)
		Cadherin_repeat	372..469	CDD:206637	31/99 (31%)
		Cadherin_repeat	487..596	CDD:206637	29/108 (27%)
		Cadherin_repeat	605..703	CDD:206637	38/97 (39%)
		Cadherin_repeat	728..820	CDD:206637	30/94 (32%)
Cdhr1	NP_446024.1	Cadherin_repeat	42..130	CDD:206637	24/98 (24%)
		Cadherin_repeat	139..242	CDD:206637	27/110 (25%)
		Cadherin_repeat	251..350	CDD:206637	33/111 (30%)
		Cadherin_repeat	364..469	CDD:206637	29/108 (27%)
		Cadherin_repeat	478..573	CDD:206637	39/98 (40%)
		Cadherin_repeat	580..679	CDD:206637	33/113 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	789..859
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	4	3.870