DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad86C and CDHR1

DIOPT Version :9

Sequence 1:	NP_001247033.1	Gene:	Cad86C / 41302	FlyBaseID:	FBgn0261053	Length:	1949	Species:	Drosophila melanogaster
Sequence 2:	XP_011538639.1	Gene:	CDHR1 / 92211	HGNCID:	14550	Length:	917	Species:	Homo sapiens

Alignment Length:	784	Identity:	226/784 - (28%)
Similarity:	342/784 - (43%)	Gaps:	117/784 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 GP-IGP-WLGAMTAYRLLTISLLIGILC----------PHHVQGADPKFD-----PTTRMRLVLV 153
            || .|| |..|.        |..:|:||          |.....|...||     ....|.|..:
Human    46 GPDAGPRWCEAP--------SWCLGVLCLGVRLFCVLFPAQANFAPHFFDNGVGSTNGNMALFSL 102

  Fly   154 PADAQVNSVIYRLRATDEEFDYPLTFEFVGDASASTVKVESLPCTKYNSVCQANIVLQRRLEPGR 218
            |.|..|.|.:|.|..||.|.| |:::....|  .||..|.|:..|      ..||.|...|:..|
Human   103 PEDTPVGSHVYTLNGTDPEGD-PISYHISFD--PSTRSVFSVDPT------FGNITLVEELDRER 158

  Fly   219 YYDFQ--VSVKDTKGGMTTQ-LCSITATNFTTPHDLIFPHKPGIIMIPEDAKRGTELDYVIARKN 280
            ..:.:  :|:.|....:..: :..:|..|...|.   |..:|.:.::|||...|:    :|.:.:
Human   159 EDEIEAIISISDGLNLVAEKVVILVTDANDEAPR---FIQEPYVALVPEDIPAGS----IIFKVH 216

  Fly   281 PLFQK-------PVYLELWGSPLFAIRQKIVSSETTEGTVFLL--GPLDFEKQAMYHLTILANDA 336
            .:.:.       ..:|:...|| ||:       :...|.:.|.  ..||:|:...:::|::|.|.
Human   217 AVDRDTGSGGSVTYFLQNLHSP-FAV-------DRHSGVLRLQAGATLDYERSRTHYITVVAKDG 273

  Fly   337 YAE-PGQDSRNIAGMEIVVIVQDVQDQPPVFTSAPPVTKLPPGILPGDKILQVHAEDGDKGNPRE 400
            ... .|.|....|...:.|.|:||||..|||...|....:....|||.::|:|.|.|||:|.|..
Human   274 GGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNR 338

  Fly   401 VRYGLVSENNPFTSFFDINETSGEIFLMR---PLEDIAFITHVGDPVLLTVIAEEVKVGRDEPPA 462
            :.|.||:.|:   ..|:||||||.|.:.:   .|:...:..||       .:.|....|   .||
Human   339 ILYSLVNGND---GAFEINETSGAISITQSPAQLQREVYELHV-------QVTEMSPAG---SPA 390

  Fly   463 LASTVQLAFFLPDRTNSPPYF-----ENDHYVSRVDENAPHGTALTFVDPYVPRVYDDDTGKNGV 522
            ..:||.:...:.|..|.||.|     ..:.:...::|:.|.|..|..:.   ..|.|.|.|.|..
Human   391 AQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLK---ITVNDSDQGANAK 452

  Fly   523 FSLTLLNNNGTFEISPNVAERSAGFLIRVRDNSMLDYEQQQSVQFQILAQELGPATNLSALVNVT 587
            |:|.|:...|.|.:.|......|...|.|.:::.:|:|:.:.:.|::||.|:......|:..:|.
Human   453 FNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVV 517

  Fly   588 VYINDVNDNAPVFEQPAYSVELPENMTAGTKVVQVLATDPDSGLGGKVRYTAILGYLNTSLNL-- 650
            :.:.|.|||.|.|:...|...:|||...|:.||.|.|.|||:|..|:|:|:.    ..|..:|
Human   518 IQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYST----YGTGADLFL 578

  Fly   651 -DAETGLITVSTNKHGFDREVMPEYHLYVEARDMDGEGNRAQVPLIIKLIDVNDETPIFDKDLYE 714
             ...|||| .:......|.|....|:.||:|.||:|:.:.|:|  .|.|:||||..|.|.|.:.:
Human   579 IHPSTGLI-YTQPWASLDAEATARYNFYVKAEDMEGKYSVAEV--FITLLDVNDHPPQFGKSVQK 640

  Fly   715 FILTHDLMGFTTTAVIHAEDKDATAPNNEVRYEIINGNYDNQFVLDKVTGELTVREKIHLRSKKN 779
                 ..|...|...|.|.|:||..|||.|.|.|.:....|.|.::..|||:.::..|     ::
Human   641 -----KTMVLGTPVKIEAIDEDAEEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSI-----RS 695

  Fly   780 AKTRRRRQAGSDDEDTDIFILTARAYDLGVPVRFSTTT---IRVYPPESRKRS--VKFVV-PGHN 838
            .........|.|    .::.|..:|.|.|.| .||||.   |.:...|:..||  ..|:: ...|
Human   696 LDALHNITPGRD----CLWSLEVQAKDRGSP-SFSTTALLKIDITDAETLSRSPMAAFLIQTKDN 755

  Fly   839 PDKA 842
            |.||
Human   756 PMKA 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad86C	NP_001247033.1	Cadherin_repeat	260..361	CDD:206637	25/110 (23%)
		Cadherin_repeat	372..469	CDD:206637	32/99 (32%)
		Cadherin_repeat	487..596	CDD:206637	28/108 (26%)
		Cadherin_repeat	605..703	CDD:206637	37/100 (37%)
		Cadherin_repeat	728..820	CDD:206637	29/94 (31%)
CDHR1	XP_011538639.1	Cadherin_repeat	100..188	CDD:206637	25/96 (26%)
		Cadherin_repeat	197..299	CDD:206637	26/113 (23%)
		Cadherin_repeat	308..407	CDD:206637	34/111 (31%)
		Cadherin_repeat	421..526	CDD:206637	28/107 (26%)
		Cadherin_repeat	535..630	CDD:206637	38/101 (38%)
		Cadherin_repeat	646..737	CDD:206637	30/100 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910