DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad86C and PCDHB16

DIOPT Version :9

Sequence 1:	NP_001247033.1	Gene:	Cad86C / 41302	FlyBaseID:	FBgn0261053	Length:	1949	Species:	Drosophila melanogaster
Sequence 2:	NP_066008.2	Gene:	PCDHB16 / 57717	HGNCID:	14546	Length:	776	Species:	Homo sapiens

Alignment Length:	733	Identity:	166/733 - (22%)
Similarity:	276/733 - (37%)	Gaps:	167/733 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 HDLIFPHKPGIIMIPEDAKRGTE------LDYVIARKNPLFQKPVYLELWGSPLFAIRQKIVSSE 307
            |..:|..|..|:.|||::..|||      ||..:...|....|.       ||....|  ::..|
Human   129 HSPMFTEKEMILKIPENSPLGTEFPLNHALDLDVGSNNVQNYKI-------SPSSHFR--VLIHE 184

  Fly   308 TTEGTVF----LLGPLDFEKQAMYHLTILANDAYAEPGQDSRNIAGMEIVVIVQDVQDQPPVFTS 368
            ..:|..:    |...||.|::....||:.|.|..:.|...:..:. :|:|    |:.|..|.|..
Human   185 FRDGRKYPELVLDKELDREEEPQLRLTLTALDGGSPPRSGTAQVR-IEVV----DINDNAPEFEQ 244

  Fly   369 APPVTKLPPGILPGDKILQVHAEDGDKGNPREVRYGLVSENNPFTSFFDINETSGEIFLMRPLED 433
            .....::|.....|..:..|.|.|.|.|...::.|.|...:...:...::|..:||:.|.:.: |
Human   245 PIYKVQIPENSPLGSLVATVSARDLDGGANGKISYTLFQPSEDISKTLEVNPMTGEVRLRKQV-D 308

  Fly   434 IAFITHVGDPVLLTVIAEEVKVGRDEPPALASTVQLAFFLPDRTNSPPYFENDHYVSRVDENAPH 498
            ...:|           :.||::...:...|:....|...:.|..::||........|.:.||:|.
Human   309 FEMVT-----------SYEVRIKATDGGGLSGKCTLLLQVVDVNDNPPQVTMSALTSPIPENSPE 362

  Fly   499 GTALTFVDPYVPRVYDDDTGKNGVFSLTLLNNNGTFEISPNVAERSAGFLIRVRDNSMLDYEQQQ 563
            .....|      .|.|.|:|.||. :::.:..:..|.:.|:|    ..|...|.:.: ||.|.:.
Human   363 IVVAVF------SVSDPDSGNNGK-TISSIQEDLPFLLKPSV----KNFYTLVTERA-LDREARA 415

  Fly   564 SVQFQILAQELGPATNLSALVNVTVYINDVNDNAPVFEQPAYSVELPENMTAGTKVVQVLATDPD 628
            .....:...::| ...|....|:||.|:|||||||.|.|.:|::.:.||.:....:..|.|||.|
Human   416 EYNITLTVTDMG-TPRLKTEHNITVQISDVNDNAPTFTQTSYTLFVRENNSPALHIGSVSATDRD 479

  Fly   629 SGLGGKVRYTAI--------LGYLNTSLNLDAETGLITVSTNKHGF-----DREVMPEYHLYVEA 680
            ||...:|.|:.:        |..| .|:|.|          |.|.|     |.|.:..:...|.|
Human   480 SGTNAQVTYSLLPPQDPHLPLASL-VSINAD----------NGHLFALRSLDYEALQAFEFRVGA 533

  Fly   681 RDMDGEGNRAQVPLIIKLIDVNDETPIFDKDLY----------EFILTHDLMGFTTTAVIHAEDK 735
            .|........:..:.:.::|.||.:|..   ||          |.:......|:..|.|: |.|.
Human   534 TDRGSPALSREALVRVLVLDANDNSPFV---LYPLQNGSAPCTELVPRAAEPGYLVTKVV-AVDG 594

  Fly   736 DATAPNNEVRYEIINGNYDNQFVLDKVTGEL-TVREKIHLRSKKNAKTRRRRQAGSDDEDTDIFI 799
            | :..|..:.|:::.......|.:....||: |.|    |.|:::|..:|
Human   595 D-SGQNAWLSYQLLKATEPGLFGVWAHNGEVRTAR----LLSERDAAKQR--------------- 639

  Fly   800 LTARAYDLGVPVRFSTTTIRVYPPESRKRSVKFVVPGHNPDKAKTEETLSALSGGKVYIHNIRPL 864
            |.....|.|.|.|.:|.|:.|           .:|.|.:                       :|.
Human   640 LVVLVKDNGEPPRSATATLHV-----------LLVDGFS-----------------------QPF 670

  Fly   865 SPDEPGAKDIPAGNPGIKERSVVTATVIYDSSSVVD------ISEIQQRLSHHNNSYAI----MP 919
            .|       :|...||..:.:.:|..::...:||..      :..:..||...:.:.::    ||
Human   671 LP-------LPEAAPGQTQANSLTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAASVGRCSMP 728

  Fly   920 Q--------DTSSTDTLT 929
            :        |.|.|.||:
Human   729 EGPFPGRLVDVSGTGTLS 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad86C	NP_001247033.1	Cadherin_repeat	260..361	CDD:206637	27/110 (25%)
		Cadherin_repeat	372..469	CDD:206637	18/96 (19%)
		Cadherin_repeat	487..596	CDD:206637	28/108 (26%)
		Cadherin_repeat	605..703	CDD:206637	26/110 (24%)
		Cadherin_repeat	728..820	CDD:206637	22/92 (24%)
PCDHB16	NP_066008.2	Cadherin_2	32..112	CDD:285466
		Cadherin_repeat	137..238	CDD:206637	28/114 (25%)
		Cadherin_repeat	246..343	CDD:206637	20/108 (19%)
		Cadherin_repeat	356..447	CDD:206637	27/103 (26%)
		Cadherin_repeat	455..557	CDD:206637	27/112 (24%)
		Cadherin_repeat	576..664	CDD:206637	25/119 (21%)
		Cadherin_C_2	685..768	CDD:293101	12/62 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X20
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000