DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad86C and PCDHA8

DIOPT Version :9

Sequence 1:	NP_001247033.1	Gene:	Cad86C / 41302	FlyBaseID:	FBgn0261053	Length:	1949	Species:	Drosophila melanogaster
Sequence 2:	NP_061734.1	Gene:	PCDHA8 / 56140	HGNCID:	8674	Length:	950	Species:	Homo sapiens

Alignment Length:	1070	Identity:	232/1070 - (21%)
Similarity:	372/1070 - (34%)	Gaps:	290/1070 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   262 IPEDAKRGT-----------ELDYVIARKNPLFQKPVYLELWGSPLFAIRQK----IVSSETTEG 311
            :||:||.||           ||..::.|                 ||.:..|    ::......|
Human    35 VPEEAKHGTFVGRIAQDLGLELAELVPR-----------------LFRVASKRHRDLLEVSLQNG 82

  Fly   312 TVFLLGPLDFEK------QAMYHLTILANDAYAEPGQDSRNIAGMEIVVIVQDVQDQPPVFTSAP 370
            .:|:...:|.|:      :...||.::.:          |.:....:.|.|:||.|.||||....
Human    83 ILFVNSRIDREELCGRSAECSIHLEVIVD----------RPLQVFHVDVEVKDVNDNPPVFRVKD 137

  Fly   371 PVTKLPPGILPGDKILQVHAEDGDKGNPREVRYGLVSENNPFTSFF--DINETSG-----EIFLM 428
            ....:....:|..:.....|.|.|.|....:.|.|.|.:     :|  |:|..:.     |:.|.
Human   138 QKLFVSESRMPDSRFPLEGASDADVGANSVLTYRLSSHD-----YFMLDVNSKNDENKLVELVLR 197

  Fly   429 RPL--EDI----AFITHVGDPVLLTVIAEEVKVGRDEPPALASTVQLAFFLPDRTNSPPYFENDH 487
            :.|  ||.    .|:|....             |:   |.|..||||...:.|..::.|.||...
Human   198 KSLDREDAPAHHLFLTATDG-------------GK---PELTGTVQLLVTVLDVNDNAPTFEQSE 246

  Fly   488 YVSRVDENAPHGTALTFVDPYVPRVYDDDTGKNGVFSLTLLNNNGTFEISPNVAERSAGFLIRVR 552
            |..|:.|||.:||.:..::     ..|.|.|.||..|.:..:...|..|.....:|:.|.:: :|
Human   247 YEVRIFENADNGTTVIKLN-----ASDPDEGANGAISYSFNSLVETMVIDHFSIDRNTGEIV-IR 305

  Fly   553 DNSMLDYEQQQSVQFQILAQELGPATNLSALVNVTVYINDVNDNAPVFEQPAYSVELPENMTAGT 617
            .|  ||:||:...:..|.|.:.|... ::....|.|.|.|.|||.|.....:.|:.:.|:...||
Human   306 GN--LDFEQENLYKILIDATDKGHPP-MAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGT 367

  Fly   618 KVVQVLATDPDSGLGGKVRYTAILGYLNTSLNLDAETGLITVSTNKH--------GFDREVMPEY 674
            .:..:...|.|||..|:|           :.:|........|||.|:        ..|||.:..|
Human   368 VIALISVNDLDSGANGQV-----------TCSLMPHVPFKLVSTFKNYYSLVLDSALDRERVSAY 421

  Fly   675 HLYVEARDMDGEGNRAQVPLIIKLIDVNDETPIFDKDLYE-FILTHDLMG---FTTTAVIHAEDK 735
            .|.|.|||.......|...|.:::.||||..|.|.:..|. |:..::..|   ||.:|      :
Human   422 ELVVTARDGGSPSLWATASLSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSA------R 480

  Fly   736 DATAPNNE-VRYEIINGNYDNQFVLDKVTGELTVRE--KIHLRSKKNAKTRRRRQAGSDDEDTDI 797
            ||.|..|. |.|.::          ::..||.::..  .:|..|.|....:     ..|.|:.::
Human   481 DADAQENALVSYSLV----------ERRVGERSLSSYISVHTESGKVYALQ-----PLDHEELEL 530

  Fly   798 FILTARAYDLGVPVRFSTTTIRVYPPESRKRSVKFVVP-------------------GHNPDKAK 843
            ......|.|.|||...|..|::|:..:....:...:.|                   ||...|.:
Human   531 LQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLEPRVGGTGGAASKLVPRSVGAGHVVAKVR 595

  Fly   844 TEETLSALSGGKVYI-HNIRPL--SPDEP----------------GAKDIPA----------GNP 879
               .:.|.||...:: :.::|.  ||..|                ...|.|.          |.|
Human   596 ---AVDADSGYNAWLSYELQPAASSPRIPFRVGLYTGEISTTRVLDEADSPRHRLLVLVKDHGEP 657

  Fly   880 GIKERSVVTATVIYDSSSVVDISEIQQRLSHHNNSYAIMPQDTSSTDTLTPLQTQYKAENKVLFW 944
            .:    ..||||:.   |:|:..:..:..|  ..|..::..:.:..|              |..:
Human   658 AL----TATATVLV---SLVESGQAPKASS--RQSAGVLGPEAALVD--------------VNVY 699

  Fly   945 LLILLATLVALTILILLL--CCICSWCPLYGAATKRIVNISRTEDDVHLVHREMANGKQTK--SV 1005
            |:|.:..:.:|.:|.|||  ...||..|..|....                     ||.|.  |.
Human   700 LIIAICAVSSLLVLTLLLYTALRCSALPTEGGCRA---------------------GKPTLVCSS 743

  Fly  1006 QVAEWMGRRD----AWSAEKPPDT---RTKPTRWEFHDGREQLDEDVGRGQDIGEGDRRHI-QSA 1062
            .|..|...:.    ..|.|.||.|   ...|.          |..|:| ..|:||....:: ...
Human   744 AVGSWSYSQQQPQRVCSGEGPPKTDLMAFSPC----------LPPDLG-SVDVGEEQDLNVDHGL 797

  Fly  1063 EEQQRRVRIKHNRTAKDDLHLNFHNSRTNLIN------DRDVYMEDVIENRDLAGDREHITRTRV 1121
            :.:|.....:::.:.:..:|.:.|.....::.      |:.............||:........|
Human   798 KPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGV 862

  Fly  1122 NRQ----EYARRKQYDSEVRHIDDD----------SMRRH----EIDRGSDIDFNTAHNSLKSKR 1168
            |..    :|.......|....:.|.          |:|:.    :||:...|.|.....:.|.|:
Human   863 NSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKK 927

  Fly  1169 ELFIKDGNVEILQLMTRDKTRDGLNLDDDN 1198
            :   |.||      .|::|...| |...||
Human   928 K---KKGN------KTQEKKEKG-NSTTDN 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad86C	NP_001247033.1	Cadherin_repeat	260..361	CDD:206637	23/119 (19%)
		Cadherin_repeat	372..469	CDD:206637	23/109 (21%)
		Cadherin_repeat	487..596	CDD:206637	31/108 (29%)
		Cadherin_repeat	605..703	CDD:206637	28/105 (27%)
		Cadherin_repeat	728..820	CDD:206637	21/94 (22%)
PCDHA8	NP_061734.1	Cadherin_2	30..111	CDD:285466	18/92 (20%)
		Cadherin_repeat	140..238	CDD:206637	26/118 (22%)
		Cadherin_repeat	246..346	CDD:206637	31/108 (29%)
		Cadherin_repeat	354..451	CDD:206637	29/107 (27%)
		Cadherin_repeat	459..561	CDD:206637	27/122 (22%)
		Cadherin_repeat	581..670	CDD:206637	19/98 (19%)
		5 X 4 AA repeats of P-X-X-P	774..894		18/130 (14%)
		Cadherin_tail	799..942	CDD:292596	25/152 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	830..950		25/128 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X20
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000