DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad86C and pcdh17

DIOPT Version :9

Sequence 1:	NP_001247033.1	Gene:	Cad86C / 41302	FlyBaseID:	FBgn0261053	Length:	1949	Species:	Drosophila melanogaster
Sequence 2:	NP_001154294.1	Gene:	pcdh17 / 561336	ZFINID:	ZDB-GENE-090608-3	Length:	1137	Species:	Danio rerio

Alignment Length:	1333	Identity:	273/1333 - (20%)
Similarity:	445/1333 - (33%)	Gaps:	387/1333 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 KYNSVCQANIVLQRRLEPGRYYDFQVSVKDTKGGMTTQLCSITA----TNFTTPHDLIFPHKPGI 259
            :.||.||.::              :|...|      .::|.|..    .|...|.   ||.:...
Zfish    87 RQNSKCQLSM--------------EVFAND------KEICMIKVEIQDINDNAPS---FPSEQID 128

  Fly   260 IMIPEDAKRGTELDYVIA-----RKNPLFQKPVYLELWGSPLFAIRQKIVSSETTEGTVFLLGPL 319
            |.|.|:|..||......|     ::|.|  |...:......:|::..|.....|....:.:...|
Zfish   129 IDISENAAPGTRFPLAAAYDPDTKENGL--KTYQITRDDYSIFSLDVKSRGDGTKFPELVVQRSL 191

  Fly   320 DFEKQAMYHLTILANDA--YAEPGQDSRNIAGMEIVVIVQDVQDQPPVFTSAPPVTKLPPGILPG 382
            |.|:::.:.|.|.|.|.  |.:.|.       |:|.|.|.|..|..|||.....|.::|.....|
Zfish   192 DREERSHHTLIITATDGGEYPKSGT-------MQINVKVTDSNDNSPVFEQPSYVVEIPENAPLG 249

  Fly   383 DKILQVHAEDGDKGNPREVRYGLVSENNPFTSFFDINETSGEIFLMRPLEDIAFITHVGDPVLLT 447
            ..|:.::|.|.|:|...:|.|.       |:.:  :.:...|:|.:.|...:..|....|.....
Zfish   250 TVIIDLNATDSDEGINGQVTYS-------FSCY--VPDRIKELFSIDPRTGVIKIQGKIDFEENP 305

  Fly   448 VIAEEVKVGRDEPPALASTVQLAFFLPDRTNSPPYFENDHYVS---------RVDENAPHGTALT 503
            :|..:|:.....|..:....::...:.||        ||::.|         .|.|.|..||.:.
Zfish   306 IIEIDVQAKDQGPNPIPGHCKVTVKVLDR--------NDNWPSIGFVAVRQGAVSEAATPGTVIA 362

  Fly   504 FVDPYVPRVYDDDTGKNGVFSLTLLNNNGTFEISPNVAERSAGFLIRVRDNSMLDYEQQQSVQFQ 568
            .|     ||.|.|:|:||.....:|.|     :...:.|....|...|.|.. ||.|.:......
Zfish   363 LV-----RVTDKDSGRNGQLQCRILGN-----VPFKLEENYDNFYTVVTDRP-LDREVKDEYNIT 416

  Fly   569 ILAQELGPATNLSALVNVTVYINDVNDNAPVFEQPAYSVELPENMTAGTKVVQVLATDPDSGLGG 633
            |:|::.|... |::..:.||.|.|.|||||.|.:..|.:::|||...|..:..|||.|||.|..|
Zfish   417 IVAKDNGNPP-LNSTKSFTVKILDENDNAPRFTKMVYLLQVPENNIPGEYLGSVLAHDPDLGQNG 480

  Fly   634 KVRYTAILG-----YLNTSLNLDAETGLITVSTNKHGFDREVMPEYHLYVEARDMDGEGNRAQVP 693
            .|.|:.:..     .:.|.:|:....|.|..   ...|:.|....:...|:|:|.......:...
Zfish   481 TVSYSLLPSNVSEESITTYVNIKPTDGAIYA---LRSFNYEQTKYFDFKVQAKDSGNPHLESNTT 542

  Fly   694 LIIKLIDVNDETPI-----FDKDLYEFILTHDL-MGFTTTAVIHAEDKDATAPNNEVRYEIINGN 752
            :.:.::||||..|:     ...|..|..:..:: :|...|.| .|.|.| ...:..:.|||.:||
Zfish   543 VRVSVLDVNDNIPVIVLPLLQNDTAEIHVPRNVGVGHIITTV-RAVDND-FGESGRLTYEISDGN 605

  Fly   753 YDNQFVLDKVTGELTVREKIHLRSKKNAKTRRRRQAGSDDEDTDIFILTARAYDLGVPVRFSTTT 817
            .::.|.:|.||||:...:.:.                  :|.|.:..|..:..|.|.|
Zfish   606 EEHLFEIDSVTGEVRTAQPLW------------------EEVTPVVELIIKVTDHGKP------- 645

  Fly   818 IRVYPPESRKRSVKFVVPGHNPDKAKTEETLSALSGGKVYIHNIRPLSPDEPGAKDIPAGNPGIK 882
                   |.....|.:|              .|.||         ||          |.|.|.|
Zfish   646 -------SLSAMAKLIV--------------KAYSG---------PL----------PEGEPRI- 669

  Fly   883 ERSVVTATVIYDSSSVVDISEIQQRLSHHNNSYAIMPQDTSSTDTLTPLQTQYKAENKVLFWLLI 947
                                    ...|||            .|...||          :..|.|
Zfish   670 ------------------------NAEHHN------------WDMSLPL----------IVTLSI 688

  Fly   948 LLATLVALTILILLLC-----------C-ICSWC-PLYGAATKRIVNISRTEDDVHLVHREMANG 999
            :...|:|..|.|.:.|           | |..:. |..|.:.|:.:|    ::|:.||..|:..
Zfish   689 ISIMLLAAMITIAVKCKRENKEIRTYNCRIAEYSHPQLGKSKKKKIN----KNDIMLVQSEVEE- 748

  Fly  1000 KQTKSVQVAEWMGRRDAWSAEKPPDTRTKPTRWEFHDGREQLDEDVGRGQDIGEGDRRHIQSAEE 1064
            :.|.:|.           :....|...|.|..:::.                   .|..:.|...
Zfish   749 RDTMNVM-----------NVVSSPSLATSPMYFDYQ-------------------TRLPLSSPRS 783

  Fly  1065 QQRRVRIKHNRTAKDDLHLNFHNSRTNLINDRDVYMEDVIENRDLAGDREHITRTRVNRQEYARR 1129
            :...::...|..:....|:..|.|.|                    |...:.|.|.|||....:.
Zfish   784 EVMYLKPTANNLSVPQGHVGCHTSFT--------------------GPVTNTTETPVNRMSIIQT 828

  Fly  1130 KQYDSEVRHIDDDSMRRHEIDRGSDIDFNTAHNSLKSKRELFIKD-GNVEILQLMTRDKTRDGLN 1193
            ..:.:|..::            |:...|..:.::.|......::| |:.:..|..:...|..|..
Zfish   829 DNFPAEPNYM------------GNRQQFVQSSSTFKDPERASLRDSGHGDSDQADSDQDTNKGSC 881

  Fly  1194 LDDDNIYVNVPLKPAGNLSHPQLLMVDNTGKEILMRRFIEEQPDGKQIIREHYQIVPGATYIQSM 1258
            .|               :|..:.|.:..||   |..:.:|::.|......|..  |.|.:....|
Zfish   882 CD---------------MSAKEALKMKATG---LKPQPLEQEEDCLNCTEECR--VLGHSDRCWM 926

  Fly  1259 PNEVQQGSTLKGDTFPLGKSGPNSIVYSQLEPEVKVIHTQP---VQAG-EGVSLDQQMQPAVSNQ 1319
            |.            ||.|..|..:       |:.:....:.   |.|| |.|:::.:....|.|.
Zfish   927 PQ------------FPAGAGGAGT-------PQAEGSDYRTNLFVPAGMEAVAVETETYETVCNP 972

  Fly  1320 S--------LTHELEHSLKQQNALLRQILMEKEKLENAYTQHEVALETQSLPGQSMAIGTQTDCD 1376
            :        .....:|::...|.        |..|:   |:..::...|.:|  |.:......|.
Zfish   973 NGKKTFCTFGKERRDHTILVANV--------KPYLK---TKRALSPLLQEVP--SASCSPTKGCS 1024

  Fly  1377 AGTQTEGFDGVLD-----PEISLAKPSRRRARSENDESMSEDGYEYVRFNPPNSPEGVYWIKRRR 1436
            .|:......|:.|     |..|...|...:..|.|.:: .|.||..:   ||:.|
Zfish  1025 TGSPCSSAKGMGDGAEGKPSTSHYGPPDGQYISPNKQN-KEQGYSTL---PPSDP---------- 1075

  Fly  1437 TKKRPRQPRKRIVMVEEVKRKIRTPIKEEEEVQ 1469
                          |.:|..:.|:.|.:|..|:
Zfish  1076 --------------VAKVLAEARSRISQETAVE 1094

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad86C	NP_001247033.1	Cadherin_repeat	260..361	CDD:206637	27/107 (25%)
		Cadherin_repeat	372..469	CDD:206637	19/96 (20%)
		Cadherin_repeat	487..596	CDD:206637	32/117 (27%)
		Cadherin_repeat	605..703	CDD:206637	26/102 (25%)
		Cadherin_repeat	728..820	CDD:206637	21/91 (23%)
pcdh17	NP_001154294.1	E_set	21..102	CDD:298831	5/28 (18%)
		Cadherin_repeat	131..229	CDD:206637	26/106 (25%)
		Cadherin_repeat	237..337	CDD:206637	22/116 (19%)
		Cadherin_repeat	351..443	CDD:206637	31/103 (30%)
		Cadherin_repeat	451..553	CDD:206637	27/104 (26%)
		Cadherin_repeat	568..656	CDD:206637	27/135 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X20
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000