DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad86C and PCDHB11

DIOPT Version :9

Sequence 1:	NP_001247033.1	Gene:	Cad86C / 41302	FlyBaseID:	FBgn0261053	Length:	1949	Species:	Drosophila melanogaster
Sequence 2:	NP_061754.1	Gene:	PCDHB11 / 56125	HGNCID:	8682	Length:	797	Species:	Homo sapiens

Alignment Length:	725	Identity:	173/725 - (23%)
Similarity:	266/725 - (36%)	Gaps:	165/725 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 GDASAS-TVKVESL-----PCTKYNSVCQANIVLQRRLEPGRYYDFQVSVKDTKGGMTTQLCSIT 241
            ||...| |:..|.|     ||..:..|...|        |.::...::.|:|
Human    82 GDLLLSETLDREELCGSIEPCVLHLQVLMQN--------PTQFLQIELQVRD------------- 125

  Fly   242 ATNFTTPHDLIFPHKPGIIMIPEDAKRGT--------ELDYVIARKNPLFQKPVYLELWGSPLFA 298
                ...|..||..|..::.|||::..|.        :||..|.........|       :..|.
Human   126 ----INDHSPIFSEKQMLLEIPENSPVGAVFLLESAKDLDVGINAVKSYTISP-------NSHFH 179

  Fly   299 IRQKIVSSETTEGTVFLLGPLDFEKQAMYHLTILANDAYAEPGQDSRNIAGMEIV-VIVQDVQDQ 362
            |:.:::........:.|...||:|:.......:.|.|..:.|.      :|..:| |:|.|:.|.
Human   180 IKMRVIPDNRKYPELVLDKALDYEELPELSFILSALDGGSPPR------SGTALVRVVVVDINDN 238

  Fly   363 PPVFTSAPPVTKLPPGILPGDKILQVHAEDGDKGNPREVRYGLVSENNPFTSFFDINETSGEIFL 427
            .|.|..|....|:....:.|..||.|.|.|.|.|...|:.|.....:......|:||:.||||.|
Human   239 SPEFEQAFYEVKIRENSILGSLILIVSAWDLDSGTNGEICYTFSHASEDIRKTFEINQKSGEITL 303

  Fly   428 MRPL-----EDIAFITHVGDPVLL----TVIAEEVKVGRDEPPALASTVQLAFFLPDRTNSPPYF 483
            ..||     |..:.|....|...|    |||...:.|..:.|....|::
Human   304 RAPLDFETIESYSIIIQATDGGGLFGKSTVIIHVIDVNDNAPEITVSSI---------------- 352

  Fly   484 ENDHYVSRVDENAPHGTALTFVDPYVPRVYDDDTGKNG--VFSLTLLNNNGTFEISPNVAERSAG 546
                 .|.:.||.|....:.|      .:.|.|:|.||  |.|:.        |..|.|.:.|..
Human   353 -----TSPIPENTPETVVMVF------SIQDIDSGDNGRIVCSIP--------EDLPFVLKSSVE 398

  Fly   547 FLIRVRDNSMLDYEQQQSVQFQILAQELGPATNLSALVNVTVYINDVNDNAPVFEQPAYSVELPE 611
            ....:.....||.|........|...:|| ...|....|.||.::|||||||.|.|.:|::.:.|
Human   399 NYYTLETERPLDRESTAEYNITITVTDLG-IPRLKTEHNTTVLVSDVNDNAPTFTQTSYTLFVRE 462

  Fly   612 NMTAGTKVVQVLATDPDSGLGGKVRYTAILGYLNTSLNLDAETGLITVST-NKHGF-----DREV 670
            |.:....:..|.|||.|||...:|.| ::|...:..|.|   ..|::::| |.|.|     |.|.
Human   463 NNSPALHIGSVSATDRDSGTNAQVNY-SLLPPQDLHLPL---ASLVSINTDNGHLFALRSLDYEA 523

  Fly   671 MPEYHLYVEARDMDGEGNRAQVPLIIKLIDVNDETPIFDKDLY----------EFILTHDLMGFT 725
            :..:...|.|.|.......::..:.:.::|.||.:|..   ||          |.:......|:.
Human   524 LQAFDFRVGATDRGSPALSSEALVRVLVLDANDNSPFV---LYPLQNGSAPCTELVPRAAEPGYL 585

  Fly   726 TTAVIHAEDKDATAPNNEVRYEIINGNYDNQFVLDKVTGEL-TVREKIHLRSKKNAKTRRRRQAG 789
            .|.|: |.|.| :..|..:.|:::.......|.:....||: |.|    |.|:::|...|
Human   586 VTKVV-AVDGD-SGQNAWLSYQLLKATEPGLFGVWAHNGEVRTAR----LLSERDAAKHR----- 639

  Fly   790 SDDEDTDIFILTARAYDLGVPVRFSTTTIRVYPPESRKRSVKFVVPGHN------PDKAKTEETL 848
                      |.....|.|.|.|.:|.|::|           .:|.|.:      |:.|..:...
Human   640 ----------LVVLVKDNGEPPRSATATLQV-----------LLVDGFSQPYLPLPEAAPAQAQA 683

  Fly   849 SALSGGKVYI 858
            .:|:   ||:
Human   684 DSLT---VYL 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad86C	NP_001247033.1	Cadherin_repeat	260..361	CDD:206637	22/109 (20%)
		Cadherin_repeat	372..469	CDD:206637	31/105 (30%)
		Cadherin_repeat	487..596	CDD:206637	29/110 (26%)
		Cadherin_repeat	605..703	CDD:206637	26/103 (25%)
		Cadherin_repeat	728..820	CDD:206637	22/92 (24%)
PCDHB11	NP_061754.1	Cadherin_2	30..112	CDD:311943	9/29 (31%)
		Cadherin_repeat	140..238	CDD:206637	22/110 (20%)
		Cadherin_repeat	247..343	CDD:206637	29/95 (31%)
		Cadherin_repeat	356..447	CDD:206637	28/105 (27%)
		Cadherin_repeat	455..557	CDD:206637	27/105 (26%)
		Cadherin_repeat	576..664	CDD:206637	25/119 (21%)
		Cadherin_C_2	685..768	CDD:318652	3/9 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X20
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000