DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad86C and CDHR2

DIOPT Version :9

Sequence 1:	NP_001247033.1	Gene:	Cad86C / 41302	FlyBaseID:	FBgn0261053	Length:	1949	Species:	Drosophila melanogaster
Sequence 2:	NP_001165447.1	Gene:	CDHR2 / 54825	HGNCID:	18231	Length:	1310	Species:	Homo sapiens

Alignment Length:	908	Identity:	211/908 - (23%)
Similarity:	340/908 - (37%)	Gaps:	199/908 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 PKFDPTTRMRLVLVPADAQVNSVIYRLRATDEEFDYPLTFEFVGDAS---ASTVKVESLPCTKYN 201
            |||  ...|..|::|.|..|.:..:.|.|.|::.| |||:...|..:   |.|.|.
Human    24 PKF--LANMTSVILPEDLPVGAQAFWLVAEDQDND-PLTYGMSGPNAYFFAVTPKT--------- 76

  Fly   202 SVCQANIVLQRRLEPGRYYDFQVSVKDTKGGMTTQ---LCSITATNFTTPHDLIFPHKPGIIMIP 263
                ..:.|...|:....|.|:|::..:...:..|   |..:...|...|   :|.:......|.
Human    77 ----GEVKLASALDYETLYTFKVTISVSDPYIQVQREMLVIVEDRNDNAP---VFQNTAFSTSIN 134

  Fly   264 EDAKRGTELDYVIARKNPLFQKPVYLELWGSPLFAIRQKIVSSETTE--------GTVFLLGPLD 320
            |....|:.:..|:|....:...       |..:::|.:.|.|:..:|        |::.|.|.|.
Human   135 ETLPVGSVVFSVLAVDKDMGSA-------GMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLS 192

  Fly   321 F-EKQAMYHLTILANDAYAEPGQDSRNIAGME-------------IVVIVQDVQDQPPVFTSAPP 371
            : .|.|.|.|.:.|.|           :.||.             :.:.|.|..|..|.|.....
Human   193 YNNKSAFYQLELKACD-----------LGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFY 246

  Fly   372 VTKLPPGILPGDKILQVHAEDGDKGNPREVRYGLVSENNPFTSFFDINETSGEIFLMRPLEDIAF 436
            ...:......|..:|.|.|.|||||....|.|.:.....|  .:|||. ..|.|.:...| |...
Human   247 SASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRP--GWFDIG-ADGVIRVNGSL-DREQ 307

  Fly   437 ITHVGDPVLLTVIAEEVKV---GRDEPPALASTVQLAFFLPDRTNSPPYFEN------------- 485
            :....:.|.|.|.|.|..:   |::...::..||::.    |..:..|.|.|
Human   308 LLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVM----DVNDHKPEFYNCSLPACTFTPEEA 368

  Fly   486 -DHYVSRVDENAPHGTALTFVDPYVPRVYDDDTGKNGVFSLTLLNNNG-TFEISPNVAERSAGFL 548
             .::...|||   |.:....:|.....|||.|.|.||.|.|:|...:. .|.:||..|..||...
Human   369 QVNFTGYVDE---HASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAVGSASVQ 430

  Fly   549 IRVRDNSMLDYEQQQSVQFQILAQELGPATNLSALVNVTVYINDVNDNAPVFEQPAYSVELPENM 613
            :.||.::::|||:|.::..|::|.: ..:.|.|..: ||:::.|:||:.|.|.|..|.:.:||:.
Human   431 VLVRVSALVDYERQTAMAVQVVATD-SVSQNFSVAM-VTIHLRDINDHRPTFPQSLYVLTVPEHS 493

  Fly   614 TAGTKVV-QVLATDPDSGLGGKVRYTAILGYLNTSLNLDAETGLITVSTNKHGFDREVMPEYHLY 677
            ..|:.|. .:.|||||:|..|::.|:.:.|.......:|..:|.:|| .|....|||....|:|.
Human   494 ATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTV-RNGELLDRESQAVYYLT 557

  Fly   678 VEARDMDGEGNRAQVPLIIKLIDVNDETPIFDKDLYEFILTHDLMGFTTTAVIHAEDKDATAPNN 742
            ::|  .||....:...|.|.|:|:||..|:.......|:...:   ...:..|.|.|.|....||
Human   558 LQA--TDGGNLSSSTTLQIHLLDINDNAPVVSGSYNIFVQEEE---GNVSVTIQAHDNDEPGTNN 617

  Fly   743 -EVRYEIINGNYDNQFVLDKVTGELTVREKIHLRSKKNAKTRRRRQAGSDDEDT------DIFIL 800
             .:.:.::.|.|.:.|.||..||.|                   |..|..|.:.      ...:|
Human   618 SRLLFNLLPGPYSHNFSLDPDTGLL-------------------RNLGPLDREAIDPALEGRIVL 663

  Fly   801 TARAYDLGVPVRFSTTTIRVYP-------PESRKRSVKFVVPGHNP------------DKAKTEE 846
            |....|.|.||..:...:.:..       |...:.|..|.|...:|            |:.:...
Human   664 TVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDPGVLVGVVKAWDADQTEANN 728

  Fly   847 TLS-ALSGGKVYIHNIRPL----------------------------------SPDEPGAKDIPA 876
            .:| :|||.......||.|                                  :||..|.:.|..
Human   729 RISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGETIVD 793

  Fly   877 GNPGIKERSVVTATVIYDSSSVVDISEIQ-----QRLSHHNNSYAIMPQDTSSTDTLTPLQTQ 934
            ....:|:        :.|:...:|::.::     :..|.|.....::..|   .||...|:.|
Human   794 VCVNVKD--------VNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASD---VDTSAQLEIQ 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad86C	NP_001247033.1	Cadherin_repeat	260..361	CDD:206637	24/122 (20%)
		Cadherin_repeat	372..469	CDD:206637	27/99 (27%)
		Cadherin_repeat	487..596	CDD:206637	35/109 (32%)
		Cadherin_repeat	605..703	CDD:206637	31/98 (32%)
		Cadherin_repeat	728..820	CDD:206637	23/98 (23%)
CDHR2	NP_001165447.1	Cadherin_repeat	32..120	CDD:206637	23/101 (23%)
		Cadherin_repeat	129..236	CDD:206637	24/124 (19%)
		Cadherin_repeat	246..349	CDD:206637	28/110 (25%)
		Cadherin_repeat	372..476	CDD:206637	35/108 (32%)
		Cadherin_repeat	485..582	CDD:206637	32/99 (32%)
		Cadherin_repeat	589..691	CDD:206637	24/123 (20%)
		Cadherin_repeat	699..804	CDD:206637	17/112 (15%)
		CA	<864..926	CDD:214520
		Cadherin_repeat	935..1044	CDD:206637
		Mediates interaction with USH1C and MYO7B and is required for proper localization to microvilli tips and function in microvilli organization. /evidence=ECO:0000269\|PubMed:24725409	1180..1310
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1259..1310
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000