DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad86C and pcdh2aa15

DIOPT Version :9

Sequence 1:	NP_001247033.1	Gene:	Cad86C / 41302	FlyBaseID:	FBgn0261053	Length:	1949	Species:	Drosophila melanogaster
Sequence 2:	NP_001009586.2	Gene:	pcdh2aa15 / 493601	ZFINID:	ZDB-GENE-041118-15	Length:	939	Species:	Danio rerio

Alignment Length:	796	Identity:	190/796 - (23%)
Similarity:	302/796 - (37%)	Gaps:	205/796 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   262 IPEDAKRGTELDYVIARKNPLFQKPV------YLELWGSPLFAIRQKIVSSETTEGTVFLLGPLD 320
            |.|:.|.||.:..| |:...:..|.:      .:...|..:|::.|       .:|.:::.|.||
Zfish    37 ISEEQKDGTAVGNV-AKDLGIDPKTLKERGFRIVSTSGESMFSVNQ-------NDGVLYVKGKLD 93

  Fly   321 FEKQAMYHLTILAN--DAYAEPGQDSRNIAGMEI---VVIVQDVQDQPPVFTSAPPVTKLPPGIL 380
            .|.........|.|  .|...|         :||   .|.|.||.|..|:|.......::...:|
Zfish    94 RENVCERSTPCLINLKIALENP---------LEIHYVTVDVIDVNDHAPMFPEQEKRLEISETVL 149

  Fly   381 PGDKILQVHAEDGDKGNPREVRYGLVSENNPFTSFFDI----NETSGEI---FLMRPLEDIAFIT 438
            ||.:.....|.|.|.|:.....|.|     ..|.:|.|    ....|::   .|.:||:     .
Zfish   150 PGARFQLQAARDPDSGSNSVQTYKL-----SHTEYFRIEIKDRYEDGKVPVLILQKPLD-----R 204

  Fly   439 HVGDPVLLTVIAEEVKVGRDEPPALASTVQLAFFLPDRTNSPPYFENDHYVSRVDENAPHGTALT 503
            .|...:.|.:.|  :..||   |..:..:.:...:.|..::.|.|..:.|...::||.|.||.:.
Zfish   205 EVTKSIKLQLTA--LDGGR---PPKSGKMTIIIDVLDINDNAPVFIKEVYSVTLNENTPVGTTIL 264

  Fly   504 FVDPYVPRVYDDDTGKNGVFSLTL---LNN--NGTFEISPNVAERSAGFLIRVRDNSMLDYEQQQ 563
            .|:     ..|.|.|:|||...:|   :|:  ...|.::|...|        :....:||:|.:.
Zfish   265 RVN-----ATDLDEGQNGVVVYSLGHDVNDKLRKLFNVNPVTGE--------IVVTGLLDFEVKD 316

  Fly   564 SVQFQILAQELGPATNLSALVNVTVYINDVNDNAPVFEQPAYSVELPENMTAGTKVVQVLATDPD 628
            ..:..|.|.:.|.|. |:...:||:.|.|||||.|..|..:.|..:||:...||.|..:..:|.|
Zfish   317 IYEIDIQASDKGIAP-LTTDKSVTIKIADVNDNEPQIEVTSLSSTIPEDSKPGTTVALISVSDLD 380

  Fly   629 SGLGGKVRYTAILGYLNTSLNLDAET---------GLITVSTNKHGFDREVMPEYHLYVEARDMD 684
            ||:.|:|.       .:.|.|:..:.         .|:|.|    ..|||.:..|.:.:||:|
Zfish   381 SGINGRVT-------CSLSENIPFQLMPSSQENTYSLVTTS----ALDRETIAHYDITLEAKD-- 432

  Fly   685 GEGNRAQVPL------IIKLIDVNDETPIFDKDLYEFILTHDLMGFTTTAVIHAEDKDATAPNNE 743
                ..|.||      .:::.||||.:|.|....|.|.:..:.....:...:.|.||| |..|:.
Zfish   433 ----AGQPPLSSVKSVTVQISDVNDNSPEFSSSPYAFYVMENNAPGKSLFSVSASDKD-TGANSA 492

  Fly   744 VRYEI-INGNYDNQFV----LDKVTGELTVREKIHLRSKKNAKTRRRRQAGSDDEDTDIFILTAR 803
            |.|:| .:|..:|:|.    ::...||:...:..                  |.|.:..|.....
Zfish   493 VSYQIWRDGGAENKFTSFININSENGEIYALKSF------------------DFETSKTFQFHIL 539

  Fly   804 AYDLGVPVRFSTTTIRVY--------P----PESRKRSVKFV--VP-----GHNPDKAK------ 843
            |.|.|.|...|..|:.|:        |    |.|...|.:.|  :|     ||...|.:
Zfish   540 ATDSGSPSLSSNVTVNVFILDQNDNVPVILYPVSANGSAEGVEEIPRNVNAGHLVTKVRAYDADI 604

  Fly   844 -------------TEETLSALSGGKVYIHNIRPL----SPDEPGAKDI----PAGNPGIKERSVV 887
                         ::.:|.||..   |...||.|    ..||...|.:    ..||..:.    .
Zfish   605 GYNGWLLFSLQEVSDHSLFALDR---YTGQIRTLRSFTETDEAQHKLVILVKDNGNVSLS----A 662

  Fly   888 TATVIYDSSSVVDISEIQQRLSHHNNSYAIMPQDTSSTDTLTPLQTQYKAENKVLFWLLILLAT- 951
            |||||.   .||:..|            |....|..:.:       :.:.||.|.|:|:|.|.:
Zfish   663 TATVIV---KVVEPKE------------AFAASDVKNAE-------KDEEENNVTFYLIITLGSV 705

  Fly   952 ----LVALTILILLLC 963
                ::::.:||::.|
Zfish   706 SVLFVISIIVLIVMQC 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad86C	NP_001247033.1	Cadherin_repeat	260..361	CDD:206637	26/109 (24%)
		Cadherin_repeat	372..469	CDD:206637	22/103 (21%)
		Cadherin_repeat	487..596	CDD:206637	32/113 (28%)
		Cadherin_repeat	605..703	CDD:206637	29/112 (26%)
		Cadherin_repeat	728..820	CDD:206637	23/96 (24%)
pcdh2aa15	NP_001009586.2	E_set	32..114	CDD:324323	19/84 (23%)
		Cadherin_repeat	141..240	CDD:206637	23/113 (20%)
		Cadherin_repeat	248..348	CDD:206637	32/113 (28%)
		Cadherin_repeat	360..454	CDD:206637	29/110 (26%)
		Cadherin_repeat	462..564	CDD:206637	26/120 (22%)
		Cadherin_repeat	583..671	CDD:206637	21/97 (22%)
		Cadherin_C_2	693..>747	CDD:318652	8/29 (28%)
		Cadherin_tail	794..911	CDD:318236
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X20
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000