DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad86C and pcdh2aa1

DIOPT Version :9

Sequence 1:	NP_001247033.1	Gene:	Cad86C / 41302	FlyBaseID:	FBgn0261053	Length:	1949	Species:	Drosophila melanogaster
Sequence 2:	NP_001009585.2	Gene:	pcdh2aa1 / 493596	ZFINID:	ZDB-GENE-041118-13	Length:	931	Species:	Danio rerio

Alignment Length:	847	Identity:	193/847 - (22%)
Similarity:	302/847 - (35%)	Gaps:	223/847 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 LPCTKYNS---VCQANIVLQRRLEPGRYYDFQVSVKDTKGGMTTQLCSITATNFT----TPHDLI 252
            |.|..:||   ..|.|..||...:.|      |:|.:....:.....|:...||.    |..:|.
Zfish    16 LMCLLFNSGGKAAQINYSLQEESKIG------VNVGNIAKDLGIDPTSLENRNFRIVVGTKQELF 74

  Fly   253 -FPHKPGIIMIPEDAKRGTELDYVIARKNPLFQKPVYLELWGSPLFAIRQKIVSSETTEGTVFLL 316
             ..|:.|.:.:.:...|    :.:.|:.||..               |..|.|          :.
Zfish    75 RVNHEDGALFVSQRIDR----EELCAKINPCL---------------INLKAV----------IE 110

  Fly   317 GPLDFEKQAMYHLTILANDAYAEPGQDSRNIAGMEIVVIVQDVQDQPPVFTSAPPVTKLPPGILP 381
            .||:..                            :|.|.:.||.|.||.|.......::....:.
Zfish   111 NPLEMH----------------------------QISVDIIDVNDNPPSFLDENYKLEILESAMT 147

  Fly   382 GDKILQVHAEDGDKGNPREVRYGLVSENNPFTSFFDINETSGEI---FLMRPLEDIAFITHVGDP 443
            |.:.....|.|.|.|:.....|.| |:|:.|....:.....|:|   .|.:||:......|
Zfish   148 GARFQVETAHDPDIGSNDLQSYKL-SQNHYFRLETEDMGDEGKIPVLILQKPLDREKSARH---- 207

  Fly   444 VLLTVIAEEVKVGRDEPPALASTVQLAFFLPDRTNSPPYFENDHYVSRVDENAPHGTALTFVDPY 508
               .:|......|:   |..::...:...:.|..::.|..:...|...|.|:||.||.|..|:
Zfish   208 ---NLILTATDGGK---PHKSAAANITIVVSDVNDNTPVCDKQKYTVTVKEDAPEGTFLLRVN-- 264

  Fly   509 VPRVYDDDTGKNGVFSLTLLNN-----NGTFEISPNVAERSAGFLIRVRDNSMLDYEQQQSVQFQ 568
               ..|.|.|.||....:|.|.     :..|::.....|      ::::..  |::|::|..:.:
Zfish   265 ---ASDSDEGVNGEIEYSLRNKFRKGASDVFDLDNITGE------LKIKGG--LNFEERQVYELK 318

  Fly   569 ILAQELGPATNLSALVNVTVYINDVNDNAPVFEQPAYSVELPENMTAGTKVVQVLATDPDSGLGG 633
            |||.:.| |.:||...||.|.:.|||||.|..:..:.|..:||:...||.|..:..||.|||:.|
Zfish   319 ILAADKG-AVSLSTQCNVLVNVEDVNDNRPEIDVTSLSSHIPEDAAPGTVVALIGVTDLDSGMNG 382

  Fly   634 KVRYTAILGYLNTSLNLDAET-------GLITVSTNKHGFDREVMPEYHLYVEARDMDGEGNRAQ 691
            |     |:..|..::..|.:.       .|:|    |...|:|....|.:.:.|:|:......:.
Zfish   383 K-----IICSLPKNIPFDLKPSPDGNFYSLVT----KENIDKEAKSSYDITITAKDLGSPSLSST 438

  Fly   692 VPLIIKLIDVNDETPIFDKDLYEFILTHDLMGFTTTAVIHAEDKDATAPNNEVRYEIINGNYDNQ 756
            ..:.:::.||||.:|.|.:..|.|.:|.:.........:.|.|.| ...|..|.|.|...|.|
Zfish   439 RSIHVEVTDVNDNSPKFAQSPYTFYVTENNKPGIAVFSLSASDLD-EGENARVSYTIDRINSD-- 500

  Fly   757 FVLDKVTGELTVREK----IHLRSKKNAKTRRRRQAGSDDEDTDIFILTARAYDLGVPVRFSTTT 817
               ..:|..|::.|.    ..|:|             .|.|....|.....|.|.|.|...|..|
Zfish   501 ---QSMTSFLSINEANGTVYSLKS-------------FDFESLKTFHFFVVAKDSGSPSLSSNVT 549

  Fly   818 IRVY--------P----PESRKRSVKFV--VP-----GHNPDKAK-------------------T 844
            :.|:        |    |.|...|.:.|  :|     ||...|.:                   :
Zfish   550 VNVFILDQNDNVPVILYPVSANGSAEGVEEIPRNVNAGHLVTKVRAYDADIGYNGWLLFSLQEVS 614

  Fly   845 EETLSALSGGKVYIHNIRPL----SPDEPGAKDI----PAGNPGIKERSVVTATVIYDSSSVVDI 901
            |.:|.||..   |...||.|    ..||...|.:    ..||..:.    .|||||.   .||:.
Zfish   615 EHSLFALDR---YTGQIRTLRSFTETDEAQHKLVILVKDNGNVSLS----ATATVIV---KVVEP 669

  Fly   902 SEIQQRLSHHNNSYAIMPQDTSSTDTLTPLQTQYKAENKVLFWLLILLAT-----LVALTILILL 961
            .|            |....|..:.       .:.|.||.|.|:|:|.|.:     ::::.:||::
Zfish   670 KE------------AFAASDVKNA-------VKDKEENNVTFYLIITLGSVSVLFVISIIVLIVM 715

  Fly   962 LC 963
            .|
Zfish   716 QC 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad86C	NP_001247033.1	Cadherin_repeat	260..361	CDD:206637	13/100 (13%)
		Cadherin_repeat	372..469	CDD:206637	19/99 (19%)
		Cadherin_repeat	487..596	CDD:206637	34/113 (30%)
		Cadherin_repeat	605..703	CDD:206637	26/104 (25%)
		Cadherin_repeat	728..820	CDD:206637	23/95 (24%)
pcdh2aa1	NP_001009585.2	E_set	29..111	CDD:324323	21/116 (18%)
		Cadherin_repeat	137..237	CDD:206637	20/110 (18%)
		Cadherin_repeat	246..345	CDD:206637	34/112 (30%)
		Cadherin_repeat	357..451	CDD:206637	26/102 (25%)
		Cadherin_repeat	459..560	CDD:206637	27/119 (23%)
		Cadherin_repeat	579..667	CDD:206637	22/97 (23%)
		Cadherin_C_2	689..>743	CDD:318652	8/29 (28%)
		Cadherin_tail	786..903	CDD:318236
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X20
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000