DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad86C and cdhr1a

DIOPT Version :9

Sequence 1:	NP_001247033.1	Gene:	Cad86C / 41302	FlyBaseID:	FBgn0261053	Length:	1949	Species:	Drosophila melanogaster
Sequence 2:	NP_001005402.1	Gene:	cdhr1a / 449008	ZFINID:	ZDB-GENE-040924-4	Length:	857	Species:	Danio rerio

Alignment Length:	737	Identity:	195/737 - (26%)
Similarity:	299/737 - (40%)	Gaps:	115/737 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 LLIGILCPHHVQGADPKFDP----------TTRMRLVLVPADAQVNSVIYRLRATDEE---FDYP 176
            ||:...|   ..||...:.|          ...|.|:.:..|....:.||.|..||.|   ..|.
Zfish    13 LLLAHFC---FVGAQSDYAPYFYDNGPNSNNGNMALLNLSEDTPRGTQIYVLNGTDPEGQPVKYG 74

  Fly   177 LTFE-------FVGDASASTVKVESLPCTKYNSVCQANIVLQRRLEPGRYYDFQVSVKDTKGGMT 234
            :|||       .|...|.....:|.|.....:.:                 :..||:.|:...:.
Zfish    75 ITFEPGSKEFFRVHPKSGVVTLIEDLDREAQDEI-----------------EVFVSISDSLNKVV 122

  Fly   235 TQL-CSITATNFTTPHDLIFPHKPGIIMIPEDAKRGTELDYV--IARKNPLFQKPVYL--ELWGS 294
            .:: ..|...|...|.   |.:.|.|:.:||:...|:.:..|  :.|.........|.  ....|
Zfish   123 EKVSVFIMDANDERPQ---FQNMPSIVDVPENTTSGSSIYKVQAVDRDTGSGGSVTYFLQSSEQS 184

  Fly   295 PLFAIRQ-----KIVSSETTEGTVFLLGPLDFEKQAMYHLTILANDA---YAEPGQDSRNIAGME 351
            |.|||..     :|...|:          ||:||...:.:|::|.|.   |....|...:.|.:.
Zfish   185 PKFAIDHHSGVLRIKPGES----------LDYEKSRTHFITVVAKDGGGIYKGKQQVMSSSATLT 239

  Fly   352 IVVIVQDVQDQPPVFTSAPPVTKLPPGILPGDKILQVHAEDGDKGNPREVRYGLVSENNPFTSFF 416
            |.||  |.||.||:|...|....:.....||.:|..|.|:|||..||..:.|.|.|..:   ..|
Zfish   240 INVI--DTQDSPPIFIGTPYFGYVYEVSSPGSEIFTVSAKDGDMDNPNTIIYSLDSGAD---GSF 299

  Fly   417 DINETSGEIFLMRPLEDIAFITHVGDPVLLTVIAEEVKVGRDEPPALASTVQLAFFLPDRTNSPP 481
            .||:|||.|.|.....|:.       ..:..:..:.:::..:......:|..:...:.|..|.||
Zfish   300 SINKTSGVITLNLYPADLR-------REVFNIKVKALEISPEGKRLDFATTTVTIRVVDLNNHPP 357

  Fly   482 YFENDHYVSRVDENAP----------HGTALTFVDPYVPRVYDDDTGKNGVFSLTLLNNNGTFEI 536
            .|        ..||.|          |.....|:......|.|.|.|.|..|:|.|:.......:
Zfish   358 TF--------YGENGPQNVFELTMYEHPQEGEFLRGLKITVNDSDQGSNAKFNLRLVGPGRMLRV 414

  Fly   537 SPNVAERSAGFLIRVRDNSMLDYEQQQSVQFQILAQELGPATNLSALVNVTVYINDVNDNAPVFE 601
            .|......|...:.|.|::.:|:|:.|.:.|::||.|:......||..::.:::.|.|||||.|.
Zfish   415 VPQTVLNEAQVTVLVEDSAAMDFEKSQFLTFKLLAVEIDTPERFSATADIIIHLLDTNDNAPKFT 479

  Fly   602 QPAYSVELPENMTAGTKVVQVLATDPDSGLGGKVRYTAILGYLNTSLNLDAETGLITVSTNKHGF 666
            ...|...:|||...|:.||.|.|.|||||:.|.|:| :|.|.......:.|::|:| .:......
Zfish   480 SDFYIARIPENSPGGSNVVSVTAMDPDSGIWGVVKY-SIYGSGADIFLIQADSGII-YTQPWASL 542

  Fly   667 DREVMPEYHLYVEARDMDGEGNRAQVPLIIKLIDVNDETPIFDKDLYEFILTHDLMGFTTTAVIH 731
            |.||..:|:.||:|.|.:|:.:.|:|  .:.:.|:||..|.|:::..|     ..|.......|.
Zfish   543 DAEVKSKYNFYVKAEDPEGKYSLAEV--FVTITDLNDHPPAFNENSLE-----QTMVIGAPVKIE 600

  Fly   732 AEDKDATAPNNEVRYEIINGNYDNQFVLDKVTGELTVREKIHLRSKKNAKTRRRRQAGSDDEDTD 796
            |.|:||..|||.:.|.|:..:.||.|.::..|||:.::..|.........|.:|....|
Zfish   601 AIDEDAEEPNNLIEYSIMKADPDNIFDINADTGEIKLKPYIKSMDIVQNITNQRDCTWS------ 659

  Fly   797 IFILTARAYDLGVPVRFSTTTI 818
               :..:|.|.|.| .|||||:
Zfish   660 ---VVVQAKDRGSP-SFSTTTV 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad86C	NP_001247033.1	Cadherin_repeat	260..361	CDD:206637	27/112 (24%)
		Cadherin_repeat	372..469	CDD:206637	23/96 (24%)
		Cadherin_repeat	487..596	CDD:206637	28/118 (24%)
		Cadherin_repeat	605..703	CDD:206637	34/97 (35%)
		Cadherin_repeat	728..820	CDD:206637	29/91 (32%)
cdhr1a	NP_001005402.1	Cadherin_repeat	46..134	CDD:206637	19/104 (18%)
		Cadherin_repeat	146..247	CDD:206637	27/112 (24%)
		Cadherin_repeat	256..355	CDD:206637	25/108 (23%)
		Cadherin_repeat	368..474	CDD:206637	25/105 (24%)
		Cadherin_repeat	483..578	CDD:206637	35/98 (36%)
		Cadherin_repeat	584..683	CDD:206637	31/109 (28%)
		OSTbeta	<714..>754	CDD:291707
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	746..765
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	220	1.000	Inparanoid score	I3534
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	4	4.010