DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad86C and Pcdhgb8

DIOPT Version :9

Sequence 1:	NP_001247033.1	Gene:	Cad86C / 41302	FlyBaseID:	FBgn0261053	Length:	1949	Species:	Drosophila melanogaster
Sequence 2:	NP_001032236.1	Gene:	Pcdhgb8 / 364845	RGDID:	1307432	Length:	929	Species:	Rattus norvegicus

Alignment Length:	1047	Identity:	208/1047 - (19%)
Similarity:	354/1047 - (33%)	Gaps:	326/1047 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 LGAMTAYRLLTISLLIGILCPHHVQGADPKFDPTTRMRLVLVPADAQVNSVIYRLRATDEEFDYP 176
            ||:.|.:|.:....|:.:.|....:          ::| ..:|.:..:.||:..|.   |:...|
  Rat     7 LGSRTLWRQVLFPFLLPLFCTGLAE----------QVR-YSIPEEMAMGSVVGNLA---EDLGLP 57

  Fly   177 L------TFEFVGDASASTVKVESLPCTKYNSVCQANIVLQRRLE-------------------- 215
            :      ....:.:....||..|:           .|||:..:::
  Rat    58 VQDLLIRNLRVISEKPYLTVNPEN-----------GNIVVSDKIDRELLCFQSPLCVLPLEIVAE 111

  Fly   216 -PGRYYDFQVSVKDTKGGMTTQLCSITATNFTTPHDLIFPHKPGIIMIPEDAKRGTE--LDYVI- 276
             |...:...|.::|              .|...|.   |.....::.|.|.|..||.  |:..|
  Rat   112 NPLNVFHVSVVIED--------------INDNPPR---FLQNRIVLQINEFAIPGTRFGLESAID 159

  Fly   277 ARKNPLFQKPVYLELWGSPLFAIRQKIVSSETTEG----TVFLLGPLDFEKQAMYHLTILANDAY 337
            |...|...:...|.|  :..|:    :|..:.|||    .:.|..|||.|||:...|.:.|.|.
  Rat   160 ADVGPNSLQSYQLSL--NEHFS----LVVKDKTEGKDAPELVLEKPLDREKQSSQLLVLTAVDG- 217

  Fly   338 AEPGQDSRNIAG-MEIVVIVQDVQDQPPVFTSAPPVTKLPPGILPGDKILQVHAEDGDKGNPREV 401
            .||     .:.| .:|.:.|.|..|.||||:.:.....|...:..|..:|.|.|.|.|:|...|:
  Rat   218 GEP-----VLTGTAQIQIEVTDANDNPPVFSQSTYKVSLRENMPSGTSVLTVMATDPDEGVNAEI 277

  Fly   402 RYGLVSENNPFTSFFDINETSGEIFLMRPLEDIAFITHVGDPVLLTVIAEEVKVGRDEPPALAST 466
            .|...|......|.|.::..||||....|::..|..|:.            :.:...:...:|:.
  Rat   278 TYSFKSLGEDIRSKFILDHQSGEIKSKGPIDFEARRTYT------------MNIEAKDGGGMATE 330

  Fly   467 VQLAFFLPDRTNSPPYFENDHYVSRVDENAPHGTALTFVDPYVPRVYDDDTGKNGVFSLTLLNNN 531
            .::...:.|..::.|........:.:.|:|..||.:...     :.||.|..:||..|..:.
  Rat   331 CKVVIEILDENDNAPEVVFTSVSNSITEDAEPGTVVALF-----KTYDKDAEENGRVSCFVK--- 387

  Fly   532 GTFEISPNVAERSAGFLIRVRDNSMLDYEQQQSVQFQILAQELGPATNLSALVNVTVYINDVNDN 596
               |..|...|.||....::..:.:||.||.......|:|.:.| ..:||:..:||:::.|||||
  Rat   388 ---ETVPFRIESSASNYYKLVTDGILDREQTPEYNVTIVATDKG-KPSLSSSTSVTLHVGDVNDN 448

  Fly   597 APVFEQPAYSVELPENMTAGTKVVQVLATDPDSGLGGKVRYTAILGYLN-----TSLNLDAETGL 656
            ||||.|.:|.:::.||...|..:.||.|:|||.|..|.:.|:.|...|.     :.::::.::|:
  Rat   449 APVFHQASYLIQVAENNPPGASIAQVSASDPDLGSNGLISYSIIASDLEPKSLWSYVSVNRDSGV 513

  Fly   657 ITVSTNKHGFDREVMPEYHLYVEARDMDGEGNRAQVPLIIKLIDVNDET-----PIFDKD---LY 713
            :..   :..||.|.:..:.|.::|||.......|.|.:.:.:.|.||..     |..:.|   |:
  Rat   514 VFA---QRAFDHEQLRSFQLTLQARDQGSPALSANVSMRVLVGDRNDNAPRVLYPALEPDGSALF 575

  Fly   714 EFILTHDLMGFTTTAVIHAEDKDATAPNNEVRYEIINGNYDNQFVLDKVTGELTVREKIHLRSKK 778
            :.:......|:..|.|: |.|.| :..|..:.|.::..:....|.|...|||:
  Rat   576 DMVPRAAEPGYLVTKVV-AVDAD-SGHNAWLSYHVLQASDPGLFSLGLRTGEV------------ 626

  Fly   779 NAKTRRRRQAGSDDEDTDIFILTARAYDLGVPVRFSTTTIRVYPPESRKRSVKFVVPGHNPDKAK 843
                |..|..|..|......::..|  |.|.|...:|.|:.:...:|
  Rat   627 ----RTARALGDRDSARQRLLVAVR--DGGQPPLSATATLHLIFADS------------------ 667

  Fly   844 TEETLSALSGGKVYIHNIRPLSPDEPGAKDIPAGNPGIKERSVVTATVIYDSSSVVDISEIQQRL 908
                          :..:.|...|||
  Rat   668 --------------LQEVLPELRDEP--------------------------------------- 679

  Fly   909 SHHNNSYAIMPQDTSSTDTLTPLQTQYKAENKVLFWLLILLATLVALTILILL------------ 961
                     :|.|               .:|::.|:|::.||.:..|.:.:::
  Rat   680 ---------LPSD---------------PQNELQFYLVVALALVSVLFLFVVILAIALRLRQSQG 720

  Fly   962 ----------LCC----------------------ICSWC--------------PLYGAATKRIV 980
                      |||                      :.|.|              |......:..|
  Rat   721 PAVSGCFQSGLCCKTRPGVSLNYSEGTLPYSYNLYVASNCQKMSQFLTLTPEMAPPRDLCMEASV 785

  Fly   981 NISRTEDDVHLVHREMANGKQTKSVQVAEWMGRRDAWSAEKPPDTRTKPTRWEFHDGREQLDEDV 1045
            .:|.||::..:|...:|:..|.                   ||:     |.|.|...:.......
  Rat   786 PVSVTEENNKIVSDSIASNHQA-------------------PPN-----TDWRFSQAQRPGTSGS 826

  Fly  1046 GRGQDIG 1052
            ..|.:.|
  Rat   827 QNGDETG 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad86C	NP_001247033.1	Cadherin_repeat	260..361	CDD:206637	32/108 (30%)
		Cadherin_repeat	372..469	CDD:206637	21/96 (22%)
		Cadherin_repeat	487..596	CDD:206637	29/108 (27%)
		Cadherin_repeat	605..703	CDD:206637	26/102 (25%)
		Cadherin_repeat	728..820	CDD:206637	21/91 (23%)
Pcdhgb8	NP_001032236.1	Cadherin_2	32..112	CDD:285466	13/94 (14%)
		Cadherin_repeat	138..238	CDD:206637	32/111 (29%)
		Cadherin_repeat	246..343	CDD:206637	22/108 (20%)
		Cadherin_repeat	355..448	CDD:206637	29/104 (28%)
		Cadherin_repeat	456..558	CDD:206637	27/104 (26%)
		Cadherin_repeat	578..662	CDD:206637	23/103 (22%)
		Cadherin_C_2	687..769	CDD:293101	10/81 (12%)
		Cadherin_tail	806..>902	CDD:292596	8/52 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X20
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000